Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1

Doxorubicin is a highly effective antineoplastic agent, but it can produce the serious side effects of acute cardiac injury and chronic congestive heart failure. Carbonyl reductase (CBR) has been implicated in the development of doxorubicin-induced cardiotoxicity. To test whether a decrease in CBR l...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-10, Vol.63 (20), p.6602-6606
Hauptverfasser:	OLSON, Lisa E, BEDJA, Djahida, ALVEY, Sara J, CARDOUNEL, A. J, GABRIELSON, Kathleen L, REEVES, Roger H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - deficiency Alcohol Oxidoreductases - genetics Alleles Animals Antibiotics, Antineoplastic - pharmacokinetics Antibiotics, Antineoplastic - toxicity Antineoplastic agents Biological and medical sciences Doxorubicin - analogs & derivatives Doxorubicin - pharmacokinetics Doxorubicin - toxicity Electrocardiography - drug effects Female Heart - drug effects Heart Diseases - chemically induced Heart Diseases - enzymology Heart Diseases - prevention & control Medical sciences Mice Mice, Inbred C57BL Mice, Inbred ICR Myocardium - enzymology Myocardium - pathology Pharmacology. Drug treatments Pregnancy Tumors Weight Loss - drug effects
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