R25 is an intracellular membrane receptor for a snake venom secretory phospholipase A(2)

Ammodytoxin is a presynaptically neurotoxic (beta-neurotoxic) snake venom secretory phospholipase A(2) (sPLA(2)). We detected a 25 kDa protein which binds the toxin with very high affinity (R25) in porcine cerebral cortex. Here we show that R25 is an integral membrane protein with intracellular loca...

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Veröffentlicht in:	FEBS letters 2003-10, Vol.553 (3), p.309
Hauptverfasser:	Sribar, Jernej, Copic, Alenka, Poljsak-Prijatelj, Mateja, Kuret, Jost, Logonder, Uros, Gubensek, Franc, Krizaj, Igor
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Nitrophenylphosphatase - analysis 4-Nitrophenylphosphatase - metabolism Animals Cathepsins - analysis Cathepsins - metabolism Cerebral Cortex - chemistry Cerebral Cortex - ultrastructure Group II Phospholipases A2 Intracellular Membranes - metabolism Molecular Weight NADPH-Ferrihemoprotein Reductase - analysis NADPH-Ferrihemoprotein Reductase - metabolism Organelles - enzymology Phospholipases A - metabolism Protein Binding Receptors, Cell Surface - chemistry Receptors, Cell Surface - isolation & purification Receptors, Cell Surface - metabolism Receptors, Phospholipase A2 Snake Venoms - metabolism Subcellular Fractions - metabolism Succinate Dehydrogenase - analysis Succinate Dehydrogenase - metabolism Swine Viper Venoms - metabolism
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