Parental origin of the two additional haploid sets of chromosomes in an embryo with tetraploidy
We report on the molecular investigations performed on an embryo with tetraploidy, karyotype 92,XXXY. The embryo was spontaneously aborted after eight weeks of gestation. Molecular analyses were performed in order to determine the parental origin and mode of formation of the two additional haploid s...
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| Veröffentlicht in: | Cytogenetic and genome research 2003-01, Vol.101 (1), p.5-7 |
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| creator | Baumer, A. Dres, D. Basaran, S. Isçi, H. Dehgan, T. Schinzel, A. |
| description | We report on the molecular investigations performed on an embryo with tetraploidy, karyotype 92,XXXY. The embryo was spontaneously aborted after eight weeks of gestation. Molecular analyses were performed in order to determine the parental origin and mode of formation of the two additional haploid sets of chromosomes. Microsatellite markers mapping to pericentromeric chromosome regions were used. Our results show a maternal origin of one additional set of chromosomes most likely due to the incorporation of the polar body of meiosis I and a paternal origin of the second additional set of chromosomes most likely due to dispermy. The karyotype 92,XXXY is rather unusual, indeed the vast majority of cases with tetraploidy have the karyotypes 92,XXXX or 92,XXYY. To the best of our knowledge this is the first case with 92,XXXY for which molecular investigations have been performed. |
| doi_str_mv | 10.1159/000073410 |
| format | Article |
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The embryo was spontaneously aborted after eight weeks of gestation. Molecular analyses were performed in order to determine the parental origin and mode of formation of the two additional haploid sets of chromosomes. Microsatellite markers mapping to pericentromeric chromosome regions were used. Our results show a maternal origin of one additional set of chromosomes most likely due to the incorporation of the polar body of meiosis I and a paternal origin of the second additional set of chromosomes most likely due to dispermy. The karyotype 92,XXXY is rather unusual, indeed the vast majority of cases with tetraploidy have the karyotypes 92,XXXX or 92,XXYY. To the best of our knowledge this is the first case with 92,XXXY for which molecular investigations have been performed. </description><identifier>ISSN: 1424-8581</identifier><identifier>EISSN: 1424-859X</identifier><identifier>DOI: 10.1159/000073410</identifier><identifier>PMID: 14571129</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Abortion, Spontaneous ; Adult ; Alleles ; Biological and medical sciences ; Biotechnology ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Chromosome Aberrations - embryology ; DNA - genetics ; Fatal Outcome ; Female ; Fetal Death ; Fundamental and applied biological sciences. Psychology ; Gene therapy ; Gestational Age ; Health. Pharmaceutical industry ; Humans ; Industrial applications and implications. Economical aspects ; Male ; Microsatellite Repeats - genetics ; Molecular and cellular biology ; Original Article ; Polymerase Chain Reaction ; Polyploidy</subject><ispartof>Cytogenetic and genome research, 2003-01, Vol.101 (1), p.5-7</ispartof><rights>2003 S. Karger AG, Basel</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 S. Karger AG, Basel</rights><rights>Copyright (c) 2003 S. 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The embryo was spontaneously aborted after eight weeks of gestation. Molecular analyses were performed in order to determine the parental origin and mode of formation of the two additional haploid sets of chromosomes. Microsatellite markers mapping to pericentromeric chromosome regions were used. Our results show a maternal origin of one additional set of chromosomes most likely due to the incorporation of the polar body of meiosis I and a paternal origin of the second additional set of chromosomes most likely due to dispermy. The karyotype 92,XXXY is rather unusual, indeed the vast majority of cases with tetraploidy have the karyotypes 92,XXXX or 92,XXYY. To the best of our knowledge this is the first case with 92,XXXY for which molecular investigations have been performed. </description><subject>Abortion, Spontaneous</subject><subject>Adult</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Chromosome Aberrations - embryology</subject><subject>DNA - genetics</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Fetal Death</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene therapy</subject><subject>Gestational Age</subject><subject>Health. Pharmaceutical industry</subject><subject>Humans</subject><subject>Industrial applications and implications. 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Action of oncogenes and antioncogenes</topic><topic>Chromosome Aberrations - embryology</topic><topic>DNA - genetics</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Fetal Death</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene therapy</topic><topic>Gestational Age</topic><topic>Health. Pharmaceutical industry</topic><topic>Humans</topic><topic>Industrial applications and implications. 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The embryo was spontaneously aborted after eight weeks of gestation. Molecular analyses were performed in order to determine the parental origin and mode of formation of the two additional haploid sets of chromosomes. Microsatellite markers mapping to pericentromeric chromosome regions were used. Our results show a maternal origin of one additional set of chromosomes most likely due to the incorporation of the polar body of meiosis I and a paternal origin of the second additional set of chromosomes most likely due to dispermy. The karyotype 92,XXXY is rather unusual, indeed the vast majority of cases with tetraploidy have the karyotypes 92,XXXX or 92,XXYY. To the best of our knowledge this is the first case with 92,XXXY for which molecular investigations have been performed. </abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>14571129</pmid><doi>10.1159/000073410</doi><tpages>3</tpages></addata></record> |
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| ispartof | Cytogenetic and genome research, 2003-01, Vol.101 (1), p.5-7 |
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| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Abortion, Spontaneous Adult Alleles Biological and medical sciences Biotechnology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome Aberrations - embryology DNA - genetics Fatal Outcome Female Fetal Death Fundamental and applied biological sciences. Psychology Gene therapy Gestational Age Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Male Microsatellite Repeats - genetics Molecular and cellular biology Original Article Polymerase Chain Reaction Polyploidy |
| title | Parental origin of the two additional haploid sets of chromosomes in an embryo with tetraploidy |
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