Characteristics, management and outcome of patients with recurrent tuberculosis under routine programme conditions in Malawi
SETTING: All 43 non-private hospitals in Malawi, which registered TB cases between 1 July 1999 and 30 June 2000.OBJECTIVES: To determine 1) the characteristics, management and treatment outcome, 2) timing of the previous episode of TB, and 3) pattern of drug resistance in patients registered with re...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 2003-10, Vol.7 (10), p.948-952 |
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| container_title | The international journal of tuberculosis and lung disease |
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| creator | SALANIPONI, F. M NYIRENDA, T. E KEMP, J. R SQUIRE, S. B GODFREY-FAUSSETT, P HARRIES, A. D |
| description | SETTING: All 43 non-private hospitals in Malawi, which registered TB cases between 1 July 1999 and 30 June 2000.OBJECTIVES: To determine 1) the characteristics, management and treatment outcome, 2) timing of the previous episode of TB, and 3) pattern of drug resistance in patients registered with recurrent smear-positive pulmonary TB.DESIGN: Retrospective data collection using TB registers and laboratory culture and drug sensitivity registers.RESULTS: There were 748 recurrent patients; data were available for 747. Of these, 487 (65%) successfully completed a re-treatment regimen, 185 (25%) died and the remainder had another outcome. Information about previous TB was recorded for 491 (66%) patients. In 286 (58%) there were 2 years or less between completing and re-starting treatment. Only 307 (41%) patients had sputum sent for culture and drug sensitivity tests. In 164 patients with cultures of Mycobacterium tuberculosis, 122 (81%) were fully sensitive, 25 (15%) had resistance to isoniazid and/or streptomycin, and 6 (4%) had resistance to isoniazid and rifampicin (MDR-TB).CONCLUSION: Patients with recurrent TB had acceptable treatment outcomes, and most had fully sensitive organisms. Over half had recurrent TB 2 years or less after completing treatment. Ways to prevent recurrence need to be investigated and implemented in the field. |
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M ; NYIRENDA, T. E ; KEMP, J. R ; SQUIRE, S. B ; GODFREY-FAUSSETT, P ; HARRIES, A. D</creator><creatorcontrib>SALANIPONI, F. M ; NYIRENDA, T. E ; KEMP, J. R ; SQUIRE, S. B ; GODFREY-FAUSSETT, P ; HARRIES, A. D</creatorcontrib><description>SETTING: All 43 non-private hospitals in Malawi, which registered TB cases between 1 July 1999 and 30 June 2000.OBJECTIVES: To determine 1) the characteristics, management and treatment outcome, 2) timing of the previous episode of TB, and 3) pattern of drug resistance in patients registered with recurrent smear-positive pulmonary TB.DESIGN: Retrospective data collection using TB registers and laboratory culture and drug sensitivity registers.RESULTS: There were 748 recurrent patients; data were available for 747. Of these, 487 (65%) successfully completed a re-treatment regimen, 185 (25%) died and the remainder had another outcome. Information about previous TB was recorded for 491 (66%) patients. In 286 (58%) there were 2 years or less between completing and re-starting treatment. Only 307 (41%) patients had sputum sent for culture and drug sensitivity tests. In 164 patients with cultures of Mycobacterium tuberculosis, 122 (81%) were fully sensitive, 25 (15%) had resistance to isoniazid and/or streptomycin, and 6 (4%) had resistance to isoniazid and rifampicin (MDR-TB).CONCLUSION: Patients with recurrent TB had acceptable treatment outcomes, and most had fully sensitive organisms. Over half had recurrent TB 2 years or less after completing treatment. Ways to prevent recurrence need to be investigated and implemented in the field.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>PMID: 14552564</identifier><language>eng</language><publisher>Paris, France: IUATLD</publisher><subject>Bacterial diseases ; Biological and medical sciences ; Human bacterial diseases ; Humans ; Infectious diseases ; Malawi ; Medical sciences ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - drug effects ; Mycobacterium tuberculosis - isolation & purification ; Recurrence ; Recurrent Smear-Positive Tb ; Retrospective Studies ; Sputum - microbiology ; Time Factors ; Treatment Outcome ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Multidrug-Resistant - drug therapy ; Tuberculosis, Pulmonary - drug therapy</subject><ispartof>The international journal of tuberculosis and lung disease, 2003-10, Vol.7 (10), p.948-952</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15165784$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14552564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SALANIPONI, F. M</creatorcontrib><creatorcontrib>NYIRENDA, T. E</creatorcontrib><creatorcontrib>KEMP, J. R</creatorcontrib><creatorcontrib>SQUIRE, S. B</creatorcontrib><creatorcontrib>GODFREY-FAUSSETT, P</creatorcontrib><creatorcontrib>HARRIES, A. D</creatorcontrib><title>Characteristics, management and outcome of patients with recurrent tuberculosis under routine programme conditions in Malawi</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>SETTING: All 43 non-private hospitals in Malawi, which registered TB cases between 1 July 1999 and 30 June 2000.OBJECTIVES: To determine 1) the characteristics, management and treatment outcome, 2) timing of the previous episode of TB, and 3) pattern of drug resistance in patients registered with recurrent smear-positive pulmonary TB.DESIGN: Retrospective data collection using TB registers and laboratory culture and drug sensitivity registers.RESULTS: There were 748 recurrent patients; data were available for 747. Of these, 487 (65%) successfully completed a re-treatment regimen, 185 (25%) died and the remainder had another outcome. Information about previous TB was recorded for 491 (66%) patients. In 286 (58%) there were 2 years or less between completing and re-starting treatment. Only 307 (41%) patients had sputum sent for culture and drug sensitivity tests. In 164 patients with cultures of Mycobacterium tuberculosis, 122 (81%) were fully sensitive, 25 (15%) had resistance to isoniazid and/or streptomycin, and 6 (4%) had resistance to isoniazid and rifampicin (MDR-TB).CONCLUSION: Patients with recurrent TB had acceptable treatment outcomes, and most had fully sensitive organisms. Over half had recurrent TB 2 years or less after completing treatment. Ways to prevent recurrence need to be investigated and implemented in the field.</description><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Malawi</subject><subject>Medical sciences</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Recurrence</subject><subject>Recurrent Smear-Positive Tb</subject><subject>Retrospective Studies</subject><subject>Sputum - microbiology</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Multidrug-Resistant - drug therapy</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuPFCEUhSvGifPyLxg2urISoIqiWZrWUZMxzmL25Bbc6qFTBS0PJxp__FDpNrMysoAT8t0TOOdFc8E2TLRScfqyaspl20mmzpvLlPaUcsaYfNWcs14ILob-ovmzfYAIJmN0KTuT3pMFPOxwQZ8JeEtCySYsSMJEDpBdvU7k0eUHEtGUGFcslxGjKXNILpHiLUYS65jzSA4x7CIsdd4Eb112wSfiPPkGMzy66-Zsgjnh69N51dzffLrffmlvv3_-uv1w27qe8tyaDllvZc-4mdRojWS4YVQZBhINpVKpwdZfggLGBe8l2lHIUXJU3AzAu6vm3dG2vuZHwZT14pLBeQaPoSQt65gcOvpfkCkmOsFlBd-cwDIuaPUhugXiL_031wq8PQGQDMxTBG9ceuYEG4TcrNzdkXN-V6MEvQ8l-pqFdka7Anm2em1xLVH_lJ5RzWuLdMPFaiK0xQnKnHWGqHe_dRqq5cd_WR793H7dOaWdpsclT6K6Q8yrGroneHq1cw</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>SALANIPONI, F. M</creator><creator>NYIRENDA, T. E</creator><creator>KEMP, J. R</creator><creator>SQUIRE, S. B</creator><creator>GODFREY-FAUSSETT, P</creator><creator>HARRIES, A. D</creator><general>IUATLD</general><general>Union internationale contre la tuberculose et les maladies respiratoires</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Characteristics, management and outcome of patients with recurrent tuberculosis under routine programme conditions in Malawi</title><author>SALANIPONI, F. M ; NYIRENDA, T. E ; KEMP, J. R ; SQUIRE, S. B ; GODFREY-FAUSSETT, P ; HARRIES, A. 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M</creatorcontrib><creatorcontrib>NYIRENDA, T. E</creatorcontrib><creatorcontrib>KEMP, J. R</creatorcontrib><creatorcontrib>SQUIRE, S. B</creatorcontrib><creatorcontrib>GODFREY-FAUSSETT, P</creatorcontrib><creatorcontrib>HARRIES, A. D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SALANIPONI, F. M</au><au>NYIRENDA, T. E</au><au>KEMP, J. R</au><au>SQUIRE, S. B</au><au>GODFREY-FAUSSETT, P</au><au>HARRIES, A. 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Of these, 487 (65%) successfully completed a re-treatment regimen, 185 (25%) died and the remainder had another outcome. Information about previous TB was recorded for 491 (66%) patients. In 286 (58%) there were 2 years or less between completing and re-starting treatment. Only 307 (41%) patients had sputum sent for culture and drug sensitivity tests. In 164 patients with cultures of Mycobacterium tuberculosis, 122 (81%) were fully sensitive, 25 (15%) had resistance to isoniazid and/or streptomycin, and 6 (4%) had resistance to isoniazid and rifampicin (MDR-TB).CONCLUSION: Patients with recurrent TB had acceptable treatment outcomes, and most had fully sensitive organisms. Over half had recurrent TB 2 years or less after completing treatment. Ways to prevent recurrence need to be investigated and implemented in the field.</abstract><cop>Paris, France</cop><pub>IUATLD</pub><pmid>14552564</pmid><tpages>5</tpages></addata></record> |
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| ispartof | The international journal of tuberculosis and lung disease, 2003-10, Vol.7 (10), p.948-952 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Bacterial diseases Biological and medical sciences Human bacterial diseases Humans Infectious diseases Malawi Medical sciences Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - isolation & purification Recurrence Recurrent Smear-Positive Tb Retrospective Studies Sputum - microbiology Time Factors Treatment Outcome Tuberculosis and atypical mycobacterial infections Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Pulmonary - drug therapy |
| title | Characteristics, management and outcome of patients with recurrent tuberculosis under routine programme conditions in Malawi |
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