Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha

Hypoxia-inducible factor 1 (HIF-1) regulates many genes induced by low oxygen conditions. The expression of important hypoxic genes such as glucose transporter 1 and vascular endothelial growth factor are increased in macrophages during wound healing and in the presence of the endotoxin, lipopolysac...

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Veröffentlicht in:	Blood 2004-02, Vol.103 (3), p.1124
Hauptverfasser:	Blouin, Caroline C, Pagé, Elisabeth L, Soucy, Guylaine M, Richard, Darren E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Hypoxia - genetics Cells, Cultured Gene Expression Regulation - drug effects Hypoxia-Inducible Factor 1, alpha Subunit Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Mice Phosphatidylinositol 3-Kinases - metabolism Protein Kinase C - metabolism Recombinant Proteins - biosynthesis Recombinant Proteins - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Transcription Factors - biosynthesis Transcription Factors - genetics Transcriptional Activation Transfection
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