Single-blind and comparative clinical study of the efficacy and safety of benzoyl peroxide 4% gel (BID) and adapalene 0.1% Gel (QD) in the treatment of acne vulgaris for 11 weeks
objectives: To compare the efficacy and tolerability of a gel containing benzoyl peroxide 4%, used twice daily, with a gel containing adapalene 0.1% used once daily, in the treatment of acne vulgaris for 11 weeks. methods: 178 patients bearing acne vulgaris, aged between 13 and 30 years, were studie...
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| Veröffentlicht in: | The Journal of dermatological treatment 2003-09, Vol.14 (3), p.166-171 |
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| container_title | The Journal of dermatological treatment |
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| creator | do Nascimento, LV Guedes, ACM Magalha˜es, GM de Faria, FA Guerra, RM de C Almeida, F |
| description | objectives: To compare the efficacy and tolerability of a gel containing benzoyl peroxide 4%, used twice daily, with a gel containing adapalene 0.1% used once daily, in the treatment of acne vulgaris for 11 weeks.
methods: 178 patients bearing acne vulgaris, aged between 13 and 30 years, were studied in a comparative and single-blind clinical study. The 178 patients were divided into two groups: 89 patients treated with benzoyl peroxide 4% and 89 patients treated with adapalene 0.1%. The treatment duration was 11 weeks. The efficacy assessment was conducted through an accounting of both the inflammatory and non-inflammatory lesions in all visits. The safety assessment was conducted through reports regarding adverse reactions and local tolerance in all visits and an overall tolerance at the end of the study.
conclusions: The results showed that both treatments were efficient in the reduction of acne lesions after 11 weeks treatment and were well tolerated, without any serious adverse event report. The benzoyl peroxide 4% was superior in the reduction of the number of inflammatory and non-inflammatory lesions at weeks 2 and 5, when compared to adapalene 0.1%. |
| doi_str_mv | 10.1080/09546630310007088 |
| format | Article |
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methods: 178 patients bearing acne vulgaris, aged between 13 and 30 years, were studied in a comparative and single-blind clinical study. The 178 patients were divided into two groups: 89 patients treated with benzoyl peroxide 4% and 89 patients treated with adapalene 0.1%. The treatment duration was 11 weeks. The efficacy assessment was conducted through an accounting of both the inflammatory and non-inflammatory lesions in all visits. The safety assessment was conducted through reports regarding adverse reactions and local tolerance in all visits and an overall tolerance at the end of the study.
conclusions: The results showed that both treatments were efficient in the reduction of acne lesions after 11 weeks treatment and were well tolerated, without any serious adverse event report. The benzoyl peroxide 4% was superior in the reduction of the number of inflammatory and non-inflammatory lesions at weeks 2 and 5, when compared to adapalene 0.1%.</description><identifier>ISSN: 0954-6634</identifier><identifier>EISSN: 1471-1753</identifier><identifier>DOI: 10.1080/09546630310007088</identifier><identifier>PMID: 14522627</identifier><language>eng</language><publisher>Oslo: Informa UK Ltd</publisher><subject>Acne vulgaris ; Acne Vulgaris - drug therapy ; Adapalene ; Adolescent ; Adult ; Analysis of Variance ; Benzoyl peroxide ; Benzoyl Peroxide - administration & dosage ; Benzoyl Peroxide - therapeutic use ; Biological and medical sciences ; Chi-Square Distribution ; Dermatologic Agents - administration & dosage ; Dermatologic Agents - therapeutic use ; Dermatology ; Female ; Gels ; Humans ; Male ; Medical sciences ; Naphthalenes - administration & dosage ; Naphthalenes - therapeutic use ; Single-Blind Method ; Skin involvement in other diseases. Miscellaneous. General aspects ; Treatment Outcome</subject><ispartof>The Journal of dermatological treatment, 2003-09, Vol.14 (3), p.166-171</ispartof><rights>2003 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2003</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-9432b4fc5d4e4fb8e8a430e476494cd93606f4541e654d23e9070336862f35a03</citedby><cites>FETCH-LOGICAL-c347t-9432b4fc5d4e4fb8e8a430e476494cd93606f4541e654d23e9070336862f35a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09546630310007088$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09546630310007088$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409,61194,61375</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15140363$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14522627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>do Nascimento, LV</creatorcontrib><creatorcontrib>Guedes, ACM</creatorcontrib><creatorcontrib>Magalha˜es, GM</creatorcontrib><creatorcontrib>de Faria, FA</creatorcontrib><creatorcontrib>Guerra, RM</creatorcontrib><creatorcontrib>de C Almeida, F</creatorcontrib><title>Single-blind and comparative clinical study of the efficacy and safety of benzoyl peroxide 4% gel (BID) and adapalene 0.1% Gel (QD) in the treatment of acne vulgaris for 11 weeks</title><title>The Journal of dermatological treatment</title><addtitle>J Dermatolog Treat</addtitle><description>objectives: To compare the efficacy and tolerability of a gel containing benzoyl peroxide 4%, used twice daily, with a gel containing adapalene 0.1% used once daily, in the treatment of acne vulgaris for 11 weeks.
methods: 178 patients bearing acne vulgaris, aged between 13 and 30 years, were studied in a comparative and single-blind clinical study. The 178 patients were divided into two groups: 89 patients treated with benzoyl peroxide 4% and 89 patients treated with adapalene 0.1%. The treatment duration was 11 weeks. The efficacy assessment was conducted through an accounting of both the inflammatory and non-inflammatory lesions in all visits. The safety assessment was conducted through reports regarding adverse reactions and local tolerance in all visits and an overall tolerance at the end of the study.
conclusions: The results showed that both treatments were efficient in the reduction of acne lesions after 11 weeks treatment and were well tolerated, without any serious adverse event report. The benzoyl peroxide 4% was superior in the reduction of the number of inflammatory and non-inflammatory lesions at weeks 2 and 5, when compared to adapalene 0.1%.</description><subject>Acne vulgaris</subject><subject>Acne Vulgaris - drug therapy</subject><subject>Adapalene</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Benzoyl peroxide</subject><subject>Benzoyl Peroxide - administration & dosage</subject><subject>Benzoyl Peroxide - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chi-Square Distribution</subject><subject>Dermatologic Agents - administration & dosage</subject><subject>Dermatologic Agents - therapeutic use</subject><subject>Dermatology</subject><subject>Female</subject><subject>Gels</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Naphthalenes - administration & dosage</subject><subject>Naphthalenes - therapeutic use</subject><subject>Single-Blind Method</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><subject>Treatment Outcome</subject><issn>0954-6634</issn><issn>1471-1753</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhSMEokPhAdggbwbBImDHjpMRbKBAqVQJIWAd3TjXMy5OHGynJTxWn7CeH1QhpC4sSz7fufI9J8ueMvqK0Zq-pqtSSMkpZ5TSitb1vWzBRMVyVpX8frbY6nkCxFH2KIQLShmXtH6YHTFRFoUsqkV2_c0Ma4t5a83QEUhHuX4ED9FcIlHp1SiwJMSpm4nTJG6QoNbpUc07PIDGuJNaHP642ZIRvfttOiRiSdZoyYv3Zx9e7ljoYASLA5K0wJKcbsWvSTPDbm70CLHHIW6ngUrY5WTX4E0g2nnCGLlC_BkeZw802IBPDvdx9uPTx-8nn_PzL6dnJ-_Oc8VFFfOV4EUrtCo7gUK3NdYgOEVRSbESqlulKKQWpWAoS9EVHFcpQs5lLQvNS6D8OHu-nzt692vCEJveBIXWwoBuCk1VppQ5LxLI9qDyLgSPuhm96cHPDaPNtqjmv6KS59lh-NT22N06Ds0kYHkAIKQGtIdBmXDLlUxQLnni3u45M6SQerhy3nZNhNk6_9fE7_rHm3_sGwQbNwo8Nhdu8kMK-I4tbgC9tr3Z</recordid><startdate>200309</startdate><enddate>200309</enddate><creator>do Nascimento, LV</creator><creator>Guedes, ACM</creator><creator>Magalha˜es, GM</creator><creator>de Faria, FA</creator><creator>Guerra, RM</creator><creator>de C Almeida, F</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200309</creationdate><title>Single-blind and comparative clinical study of the efficacy and safety of benzoyl peroxide 4% gel (BID) and adapalene 0.1% Gel (QD) in the treatment of acne vulgaris for 11 weeks</title><author>do Nascimento, LV ; Guedes, ACM ; Magalha˜es, GM ; de Faria, FA ; Guerra, RM ; de C Almeida, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-9432b4fc5d4e4fb8e8a430e476494cd93606f4541e654d23e9070336862f35a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acne vulgaris</topic><topic>Acne Vulgaris - drug therapy</topic><topic>Adapalene</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Benzoyl peroxide</topic><topic>Benzoyl Peroxide - administration & dosage</topic><topic>Benzoyl Peroxide - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Chi-Square Distribution</topic><topic>Dermatologic Agents - administration & dosage</topic><topic>Dermatologic Agents - therapeutic use</topic><topic>Dermatology</topic><topic>Female</topic><topic>Gels</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Naphthalenes - administration & dosage</topic><topic>Naphthalenes - therapeutic use</topic><topic>Single-Blind Method</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>do Nascimento, LV</creatorcontrib><creatorcontrib>Guedes, ACM</creatorcontrib><creatorcontrib>Magalha˜es, GM</creatorcontrib><creatorcontrib>de Faria, FA</creatorcontrib><creatorcontrib>Guerra, RM</creatorcontrib><creatorcontrib>de C Almeida, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of dermatological treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>do Nascimento, LV</au><au>Guedes, ACM</au><au>Magalha˜es, GM</au><au>de Faria, FA</au><au>Guerra, RM</au><au>de C Almeida, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single-blind and comparative clinical study of the efficacy and safety of benzoyl peroxide 4% gel (BID) and adapalene 0.1% Gel (QD) in the treatment of acne vulgaris for 11 weeks</atitle><jtitle>The Journal of dermatological treatment</jtitle><addtitle>J Dermatolog Treat</addtitle><date>2003-09</date><risdate>2003</risdate><volume>14</volume><issue>3</issue><spage>166</spage><epage>171</epage><pages>166-171</pages><issn>0954-6634</issn><eissn>1471-1753</eissn><abstract>objectives: To compare the efficacy and tolerability of a gel containing benzoyl peroxide 4%, used twice daily, with a gel containing adapalene 0.1% used once daily, in the treatment of acne vulgaris for 11 weeks.
methods: 178 patients bearing acne vulgaris, aged between 13 and 30 years, were studied in a comparative and single-blind clinical study. The 178 patients were divided into two groups: 89 patients treated with benzoyl peroxide 4% and 89 patients treated with adapalene 0.1%. The treatment duration was 11 weeks. The efficacy assessment was conducted through an accounting of both the inflammatory and non-inflammatory lesions in all visits. The safety assessment was conducted through reports regarding adverse reactions and local tolerance in all visits and an overall tolerance at the end of the study.
conclusions: The results showed that both treatments were efficient in the reduction of acne lesions after 11 weeks treatment and were well tolerated, without any serious adverse event report. The benzoyl peroxide 4% was superior in the reduction of the number of inflammatory and non-inflammatory lesions at weeks 2 and 5, when compared to adapalene 0.1%.</abstract><cop>Oslo</cop><pub>Informa UK Ltd</pub><pmid>14522627</pmid><doi>10.1080/09546630310007088</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of dermatological treatment, 2003-09, Vol.14 (3), p.166-171 |
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| source | MEDLINE; Taylor & Francis Journals Complete |
| subjects | Acne vulgaris Acne Vulgaris - drug therapy Adapalene Adolescent Adult Analysis of Variance Benzoyl peroxide Benzoyl Peroxide - administration & dosage Benzoyl Peroxide - therapeutic use Biological and medical sciences Chi-Square Distribution Dermatologic Agents - administration & dosage Dermatologic Agents - therapeutic use Dermatology Female Gels Humans Male Medical sciences Naphthalenes - administration & dosage Naphthalenes - therapeutic use Single-Blind Method Skin involvement in other diseases. Miscellaneous. General aspects Treatment Outcome |
| title | Single-blind and comparative clinical study of the efficacy and safety of benzoyl peroxide 4% gel (BID) and adapalene 0.1% Gel (QD) in the treatment of acne vulgaris for 11 weeks |
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