Enhancing targeted radiotherapy by copper(II)diacetyl-bis(n4-methylthiosemicarbazone) using 2-deoxy-D-glucose

Most cancer deaths are a consequence of resistance to conventional chemotherapy and radiation therapy. This may be attributable to unique phenotypic characteristics of solid tumors. We have exploited two well-described characteristics of solid tumors commonly associated with treatment failure, high...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-09, Vol.63 (17), p.5496-5504
Hauptverfasser:	AFT, Rebecca L, LEWIS, Jason S, FANJIE ZHANG, JOONYOUNG KIM, WELCH, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - pharmacology Biological and medical sciences Copper Radioisotopes - pharmacokinetics Copper Radioisotopes - therapeutic use Deoxyglucose - administration & dosage Deoxyglucose - pharmacology Drug Synergism Fluorodeoxyglucose F18 - pharmacokinetics Mammary Neoplasms, Experimental - diagnostic imaging Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - radiotherapy Medical sciences Mice Mice, Inbred BALB C Organometallic Compounds - pharmacokinetics Organometallic Compounds - pharmacology Radiation therapy and radiosensitizing agent Radiation-Sensitizing Agents - pharmacokinetics Radiation-Sensitizing Agents - pharmacology Radionuclide Imaging Radiopharmaceuticals - pharmacokinetics Radiopharmaceuticals - therapeutic use Thiosemicarbazones - pharmacokinetics Thiosemicarbazones - pharmacology Treatment with physical agents Treatment. General aspects Tumors
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