Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity

We have previously shown that treatment of the HT29 human colorectal tumor (HCT) cell line with 100 nM 5-fluorodeoxyuridine (FdUrd) induces DNA fragments ranging from 50 kilobases to 5 megabases. The studies reported here were conducted to characterize the kinetics, concentration dependence, and pha...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-11, Vol.89 (21), p.10474-10478
Hauptverfasser:	Canman, C E, Tang, H Y, Normolle, D P, Lawrence, T S, Maybaum, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival - drug effects Colon Colonic Neoplasms Deoxyribonucleic acid DNA DNA Damage DNA, Neoplasm - drug effects Dose-Response Relationship, Drug Drug Resistance - physiology Floxuridine - pharmacology Humans Kinetics Medical research Rectal Neoplasms Time Factors Tumor Cells, Cultured Tumors
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