Potentiation of the activity of 1-β-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells : association with enhanced fragmentation of mature DNA

We have examined the interaction between 1-beta-D-arabinofuranosylcytosine (ara-C) and the macrocyclic lactone protein kinase C activator bryostatin 1 in the human promyelocytic leukemia cell line HL-60. Preexposure of cells to 10 nM bryostatin 1 for 24 h, followed by an additional 24-h incubation w...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1992-11, Vol.52 (22), p.6270-6278
Hauptverfasser:	GRANT, S, JARVIS, W. D, SWERDLOW, P. S, TURNER, A. J, TRAYLOR, R. S, WALLACE, H. J, PECK-SUN LIN, PETTIT, G. R, GEWIRTZ, D. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Biological and medical sciences Bryostatins Calcitriol - pharmacology Cytarabine - administration & dosage Cytarabine - pharmacology DNA - drug effects DNA Damage DNA, Neoplasm - drug effects DNA, Neoplasm - metabolism Drug Synergism General aspects Humans Lactones - administration & dosage Lactones - pharmacology Leukemia, Promyelocytic, Acute - drug therapy Macrolides Medical sciences NAD - metabolism Pharmacology. Drug treatments Protein Kinase C - antagonists & inhibitors Thymidine - metabolism Time Factors Tritium Tumor Cells, Cultured
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