Comparison of Sympathetic Blocking Drugs in Prevention of Lethal Effects of Endotoxin.
Summary and conclusions The prophylactic and therapeutic effects of phenoxybenzamine, chlorpromazine, and phentolamine against the lethal effects of Escherichia coli endotoxin in mice were compared. Mortality was observed at 24 hours and 7 days to clarify the value of these agents for “long-term” pr...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1964-03, Vol.115 (3), p.627-630 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 115 |
| creator | Weil, Max H. Allen, Kenneth S. |
| description | Summary and conclusions
The prophylactic and therapeutic effects of phenoxybenzamine, chlorpromazine, and phentolamine against the lethal effects of Escherichia coli endotoxin in mice were compared. Mortality was observed at 24 hours and 7 days to clarify the value of these agents for “long-term” protection. Phenoxybenzamine, which has been recommended for therapy in clinical cases of bacterial shock, appears to be effective for prophylaxis but has no proven value for treatment in experimental animals. The beneficial effects of chlorpromazine are such that they delay rather than prevent the fatal reaction to bacterial endotoxin. However, the more lasting effectiveness of phentolamine in the treatment of reaction to endotoxin deserves further intensive study. |
| doi_str_mv | 10.3181/00379727-115-28988 |
| format | Article |
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The prophylactic and therapeutic effects of phenoxybenzamine, chlorpromazine, and phentolamine against the lethal effects of Escherichia coli endotoxin in mice were compared. Mortality was observed at 24 hours and 7 days to clarify the value of these agents for “long-term” protection. Phenoxybenzamine, which has been recommended for therapy in clinical cases of bacterial shock, appears to be effective for prophylaxis but has no proven value for treatment in experimental animals. The beneficial effects of chlorpromazine are such that they delay rather than prevent the fatal reaction to bacterial endotoxin. However, the more lasting effectiveness of phentolamine in the treatment of reaction to endotoxin deserves further intensive study.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-115-28988</identifier><identifier>PMID: 14155780</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Chlorpromazine ; Endotoxins ; Escherichia coli Infections ; Mice ; Pharmacology ; Phenoxybenzamine ; Phentolamine ; Toxicology</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1964-03, Vol.115 (3), p.627-630</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14155780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weil, Max H.</creatorcontrib><creatorcontrib>Allen, Kenneth S.</creatorcontrib><title>Comparison of Sympathetic Blocking Drugs in Prevention of Lethal Effects of Endotoxin.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary and conclusions
The prophylactic and therapeutic effects of phenoxybenzamine, chlorpromazine, and phentolamine against the lethal effects of Escherichia coli endotoxin in mice were compared. Mortality was observed at 24 hours and 7 days to clarify the value of these agents for “long-term” protection. Phenoxybenzamine, which has been recommended for therapy in clinical cases of bacterial shock, appears to be effective for prophylaxis but has no proven value for treatment in experimental animals. The beneficial effects of chlorpromazine are such that they delay rather than prevent the fatal reaction to bacterial endotoxin. However, the more lasting effectiveness of phentolamine in the treatment of reaction to endotoxin deserves further intensive study.</description><subject>Chlorpromazine</subject><subject>Endotoxins</subject><subject>Escherichia coli Infections</subject><subject>Mice</subject><subject>Pharmacology</subject><subject>Phenoxybenzamine</subject><subject>Phentolamine</subject><subject>Toxicology</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1964</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAyyQfyCtH7VjL6GUh1QJJB5by7Gd1qWNKztB9O9JSBE7VqOZOXekOQBcYjSmWOAJQjSXOckzjFlGhBTiCAwxoyyjXMpjMOyArCMG4CylNUKY5YSfggGeYsZygYbgfRa2Ox19ChUMJXzZt129crU38GYTzIevlvA2NssEfQWfo_t0Ve17duHqld7AeVk6U6duMq9sqMOXr8bn4KTUm-QuDnUE3u7mr7OHbPF0_zi7XmSGSFJnBefMMcelNtzkrLBUcEwEkqxdIC2M1XSqHTXMMjstKaFUFNwKIh2mgmo6AqS_a2JIKbpS7aLf6rhXGKlOkvqVpFpJ6kdSG7rqQ7um2Dr7FzlYaYFJDyS9dGodmli1T_x38hu0c2-w</recordid><startdate>196403</startdate><enddate>196403</enddate><creator>Weil, Max H.</creator><creator>Allen, Kenneth S.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>196403</creationdate><title>Comparison of Sympathetic Blocking Drugs in Prevention of Lethal Effects of Endotoxin.</title><author>Weil, Max H. ; Allen, Kenneth S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-b665e5e69ac6c75bd3861280956650a8cda34ae3c5d5d4f32338b6d829e1383a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1964</creationdate><topic>Chlorpromazine</topic><topic>Endotoxins</topic><topic>Escherichia coli Infections</topic><topic>Mice</topic><topic>Pharmacology</topic><topic>Phenoxybenzamine</topic><topic>Phentolamine</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weil, Max H.</creatorcontrib><creatorcontrib>Allen, Kenneth S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weil, Max H.</au><au>Allen, Kenneth S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Sympathetic Blocking Drugs in Prevention of Lethal Effects of Endotoxin.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1964-03</date><risdate>1964</risdate><volume>115</volume><issue>3</issue><spage>627</spage><epage>630</epage><pages>627-630</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary and conclusions
The prophylactic and therapeutic effects of phenoxybenzamine, chlorpromazine, and phentolamine against the lethal effects of Escherichia coli endotoxin in mice were compared. Mortality was observed at 24 hours and 7 days to clarify the value of these agents for “long-term” protection. Phenoxybenzamine, which has been recommended for therapy in clinical cases of bacterial shock, appears to be effective for prophylaxis but has no proven value for treatment in experimental animals. The beneficial effects of chlorpromazine are such that they delay rather than prevent the fatal reaction to bacterial endotoxin. However, the more lasting effectiveness of phentolamine in the treatment of reaction to endotoxin deserves further intensive study.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>14155780</pmid><doi>10.3181/00379727-115-28988</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1964-03, Vol.115 (3), p.627-630 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Chlorpromazine Endotoxins Escherichia coli Infections Mice Pharmacology Phenoxybenzamine Phentolamine Toxicology |
| title | Comparison of Sympathetic Blocking Drugs in Prevention of Lethal Effects of Endotoxin. |
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