Phase II trial of suramin in patients with advanced renal cell carcinoma : treatment results, pharmacokinetics, and tumor growth factor expression

Twenty-six patients with advanced renal cell carcinoma were treated with suramin administered by continuous infusion, with dosing determined by a nomogram. One patient achieved a partial response and five patients achieved a minor response or had stable disease for > 3 months. Toxicities included...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1992-10, Vol.52 (20), p.5775-5779
Hauptverfasser:	MOTZER, R. J.L, NANUS, D. M, BOSL, G. J, O'MOORE, P, SCHER, H. I, BAJORIN, D. F, REUTER, V, TONG, W. P, IVERSEN, J, LOUISON, C, ALBINO, A. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Biological and medical sciences Carcinoma, Renal Cell - blood Carcinoma, Renal Cell - drug therapy Chemotherapy Female Growth Substances - isolation & purification Growth Substances - metabolism Growth Substances - physiology Humans Kidney Neoplasms - blood Kidney Neoplasms - drug therapy Male Medical sciences Middle Aged Pharmacology. Drug treatments RNA, Neoplasm - isolation & purification Suramin - adverse effects Suramin - pharmacokinetics Suramin - therapeutic use Transcription, Genetic
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