Toxic effects of fluoride on the rat kidney: I. Acute injury from single large doses

1. 1. The 30-day LD 50 of sodium fluoride administered intravenously as a 2% aqueous solution in the young rat (75 days old) was 26 mg/kg. The lethal action of sodium fluoride appeared to involve two mechanisms: one causing death in a few hours and the other in 3–10 days. 2. 2. Renal injury did not...

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