Pharmacologic and radioligand binding studies of 1,4-dihydropyridines in rat cardiac and vascular preparations: stereoselectivity and voltage dependence of antagonist and activator interactions

The pharmacologic and radioligand-binding properties of 1,4-dihydropyridines in an activator (Bay K 8644) and an antagonist (nifedipine) series were studied in rat tail artery, heart membrane, and neonatal rat ventricular myocytes. The S-enantiomers of the activator series contracted rat tail artery...

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Veröffentlicht in:	Molecular pharmacology 1992-03, Vol.41 (3), p.535-541
Hauptverfasser:	WEI ZHENG, STOLTEFUSS, J, GOLDMANN, S, TRIGGLE, D. J
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Animals Arteries - drug effects Arteries - physiology Binding, Competitive Biological and medical sciences Calcium Channel Blockers - pharmacology Cardiovascular system Dihydropyridines - antagonists & inhibitors Dihydropyridines - metabolism Dihydropyridines - pharmacology Drug Antagonism Heart - drug effects Heart - physiology In Vitro Techniques Isradipine Male Medical sciences Muscle Contraction - drug effects Nifedipine - pharmacology Pharmacology. Drug treatments Radioligand Assay Rats Vasodilator agents. Cerebral vasodilators
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