Activation of beta-adrenergic receptors inhibits Ca2+ entry-mediated generation of inositol phosphates in the guinea pig myometrium, a cyclic AMP-independent event

In the guinea pig myometrium, carbachol, oxytocin, and fluoroaluminates stimulated the breakdown of phosphatidylinositol 4,5-bisphosphate, which was insensitive to pertussis toxin [Biochem. J. 255:705-713 (1988)]. We now demonstrate that an increased accumulation of inositol phosphates, with an earl...

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Veröffentlicht in:	Molecular pharmacology 1992-03, Vol.41 (3), p.509-519
Hauptverfasser:	LIEN DO KHAC, ABDELRHANI MOKHTARI, RENNER, M, HARBON, S
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Aluminum - metabolism Animals Biological and medical sciences Calcium - metabolism Calcium Channels - drug effects Calcium Channels - metabolism Carbachol - metabolism Chromatography, High Pressure Liquid Colforsin - pharmacology Cyclic AMP - metabolism Drug Antagonism Female Fluorine - metabolism Fundamental and applied biological sciences. Psychology Guinea Pigs Inositol Phosphates - metabolism Ionomycin - pharmacology Isoproterenol - pharmacology Mammalian female genital system Morphology. Physiology Myometrium - metabolism Nifedipine - pharmacology Oxytocin - metabolism Pertussis Toxin Receptors, Adrenergic, beta - metabolism Type C Phospholipases - metabolism Verapamil - pharmacology Vertebrates: reproduction Virulence Factors, Bordetella - pharmacology
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