Extracellular DNA Level in the Blood of Irradiated Rats
There is high-molecular DNA in the blood of unirradiated rats which moves as a single fraction during electrophoresis in 0·5% agarose. At short times (2-5 h) after γ-irradiation at doses from 1 to 100 Gy a low-molecular species of DNA appears (about 180 nucleotide pairs), the amount of which is dire...
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| Veröffentlicht in: | International journal of radiation biology 1992, Vol.62 (6), p.667-671 |
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| container_end_page | 671 |
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| container_issue | 6 |
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| container_title | International journal of radiation biology |
| container_volume | 62 |
| creator | Vladimirov, V.G. Belokhvostov, A.S. Sherlina, S.S. Vasilyeva, I.N. Voskresensky, A.M. |
| description | There is high-molecular DNA in the blood of unirradiated rats which moves as a single fraction during electrophoresis in 0·5% agarose. At short times (2-5 h) after γ-irradiation at doses from 1 to 100 Gy a low-molecular species of DNA appears (about 180 nucleotide pairs), the amount of which is directly proportional to exposure dose at 5 h after exposure. It has been established by Southern hybridization that the low-molecular DNA has few nucleotide sequences common with those of the high-molecular DNA, but it shows homologously to genomic sequences. |
| doi_str_mv | 10.1080/09553009214552611 |
| format | Article |
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At short times (2-5 h) after γ-irradiation at doses from 1 to 100 Gy a low-molecular species of DNA appears (about 180 nucleotide pairs), the amount of which is directly proportional to exposure dose at 5 h after exposure. It has been established by Southern hybridization that the low-molecular DNA has few nucleotide sequences common with those of the high-molecular DNA, but it shows homologously to genomic sequences.</description><identifier>ISSN: 0955-3002</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553009214552611</identifier><identifier>PMID: 1362759</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; Cesium Radioisotopes ; DNA - blood ; Extracellular Space ; Gamma Rays ; Male ; Radiation Genetics ; Radiation Injuries, Experimental - blood ; Radiation Injuries, Experimental - genetics ; Rats ; Whole-Body Irradiation</subject><ispartof>International journal of radiation biology, 1992, Vol.62 (6), p.667-671</ispartof><rights>1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-8d31a8a29806ef2053b76a7d080db8325b1478f62c5d219b7d56698eeab931223</citedby><cites>FETCH-LOGICAL-c401t-8d31a8a29806ef2053b76a7d080db8325b1478f62c5d219b7d56698eeab931223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09553009214552611$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09553009214552611$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4022,27922,27923,27924,59646,59752,60435,60541,61220,61255,61401,61436</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1362759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vladimirov, V.G.</creatorcontrib><creatorcontrib>Belokhvostov, A.S.</creatorcontrib><creatorcontrib>Sherlina, S.S.</creatorcontrib><creatorcontrib>Vasilyeva, I.N.</creatorcontrib><creatorcontrib>Voskresensky, A.M.</creatorcontrib><title>Extracellular DNA Level in the Blood of Irradiated Rats</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol</addtitle><description>There is high-molecular DNA in the blood of unirradiated rats which moves as a single fraction during electrophoresis in 0·5% agarose. At short times (2-5 h) after γ-irradiation at doses from 1 to 100 Gy a low-molecular species of DNA appears (about 180 nucleotide pairs), the amount of which is directly proportional to exposure dose at 5 h after exposure. It has been established by Southern hybridization that the low-molecular DNA has few nucleotide sequences common with those of the high-molecular DNA, but it shows homologously to genomic sequences.</description><subject>Animals</subject><subject>Cesium Radioisotopes</subject><subject>DNA - blood</subject><subject>Extracellular Space</subject><subject>Gamma Rays</subject><subject>Male</subject><subject>Radiation Genetics</subject><subject>Radiation Injuries, Experimental - blood</subject><subject>Radiation Injuries, Experimental - genetics</subject><subject>Rats</subject><subject>Whole-Body Irradiation</subject><issn>0955-3002</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1KAzEQhYMotVYfwAshL7CanyaboDdaqxaKguh1mN0kdEu6Kdmt2rd3ywoiQq_mwDfnMHMQOqfkkhJFrogWghOiGR0LwSSlB2hIuWQZ78ghGu54pwk7RidNsySdIlwN0GC3lAs9RPn0q01QuhA2ARK-f77Fc_fhAq5q3C4cvgsxWhw9nqUEtoLWWfwKbXOKjjyExp39zBF6f5i-TZ6y-cvjbHI7z8oxoW2mLKeggGlFpPOMCF7kEnLbHW8LxZko6DhXXrJSWEZ1kVshpVbOQaE5ZYyPEO1zyxSbJjlv1qlaQdoaSsyuA_Ovg85z0XvWm2Ll7K-jf7rjNz2vah_TCj5jCta0sA0x-QR1WTWG74u__mNfOAjtooTkzDJuUt3Vsee4b_keeUo</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Vladimirov, V.G.</creator><creator>Belokhvostov, A.S.</creator><creator>Sherlina, S.S.</creator><creator>Vasilyeva, I.N.</creator><creator>Voskresensky, A.M.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1992</creationdate><title>Extracellular DNA Level in the Blood of Irradiated Rats</title><author>Vladimirov, V.G. ; Belokhvostov, A.S. ; Sherlina, S.S. ; Vasilyeva, I.N. ; Voskresensky, A.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-8d31a8a29806ef2053b76a7d080db8325b1478f62c5d219b7d56698eeab931223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Cesium Radioisotopes</topic><topic>DNA - blood</topic><topic>Extracellular Space</topic><topic>Gamma Rays</topic><topic>Male</topic><topic>Radiation Genetics</topic><topic>Radiation Injuries, Experimental - blood</topic><topic>Radiation Injuries, Experimental - genetics</topic><topic>Rats</topic><topic>Whole-Body Irradiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vladimirov, V.G.</creatorcontrib><creatorcontrib>Belokhvostov, A.S.</creatorcontrib><creatorcontrib>Sherlina, S.S.</creatorcontrib><creatorcontrib>Vasilyeva, I.N.</creatorcontrib><creatorcontrib>Voskresensky, A.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vladimirov, V.G.</au><au>Belokhvostov, A.S.</au><au>Sherlina, S.S.</au><au>Vasilyeva, I.N.</au><au>Voskresensky, A.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extracellular DNA Level in the Blood of Irradiated Rats</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol</addtitle><date>1992</date><risdate>1992</risdate><volume>62</volume><issue>6</issue><spage>667</spage><epage>671</epage><pages>667-671</pages><issn>0955-3002</issn><eissn>1362-3095</eissn><abstract>There is high-molecular DNA in the blood of unirradiated rats which moves as a single fraction during electrophoresis in 0·5% agarose. At short times (2-5 h) after γ-irradiation at doses from 1 to 100 Gy a low-molecular species of DNA appears (about 180 nucleotide pairs), the amount of which is directly proportional to exposure dose at 5 h after exposure. It has been established by Southern hybridization that the low-molecular DNA has few nucleotide sequences common with those of the high-molecular DNA, but it shows homologously to genomic sequences.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>1362759</pmid><doi>10.1080/09553009214552611</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0955-3002 |
| ispartof | International journal of radiation biology, 1992, Vol.62 (6), p.667-671 |
| issn | 0955-3002 1362-3095 |
| language | eng |
| recordid | cdi_pubmed_primary_1362759 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Cesium Radioisotopes DNA - blood Extracellular Space Gamma Rays Male Radiation Genetics Radiation Injuries, Experimental - blood Radiation Injuries, Experimental - genetics Rats Whole-Body Irradiation |
| title | Extracellular DNA Level in the Blood of Irradiated Rats |
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