A Role for Microtubules in Sorting Endocytic Vesicles in Rat Hepatocytes

The vectorial nature of hepatocyte receptor-mediated endocytosis (RME) and its susceptibility to cytoskeletal disruptors has suggested that a polarized network of microtubules plays a vital role in directed movement during sorting. Using as markers a well-known ligand, asialoorosomucoid, and its rec...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-08, Vol.89 (15), p.7026-7030
Hauptverfasser:	Goltz, Jason S., Wolkoff, Allan W., Novikoff, Phyllis M., Stockert, Richard J., Satir, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Alkaloids - pharmacology Animals Asialoglycoproteins Asialoglycoproteins - metabolism Biological and medical sciences Cell Fractionation Cell physiology Cells, Cultured Cellular biology Endocytosis Endosomes Fundamental and applied biological sciences. Psychology Hepatocytes Humans Ligands Liver - physiology Liver - ultrastructure Microscopy, Electron Microtubules Microtubules - drug effects Microtubules - physiology Microtubules - ultrastructure Models, Biological Molecular and cellular biology Molecules Organelles - physiology Organelles - ultrastructure Orosomucoid - analogs & derivatives Orosomucoid - metabolism Paclitaxel Rats Receptors role Transport vesicles Vanadates vesicles
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