Liquid chromatographic mass spectrometric methods for the determination of marine polyether toxins
Experiments with novel nitrogenous coumarin-based reagents yielded moderately fluorescent derivatives of brevetoxin-3 and ciguatoxin-1. The diethylaminocoumarin-carbamic acid esters of brevetoxin-3 were resolved by high performance liquid chromatography into two derivative peaks that correspond to s...
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| Veröffentlicht in: | Bulletin de la Societe de pathologie exotique (1990) 1992, Vol.85 (5-BIS), p.514-515 |
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| container_issue | 5-BIS |
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| container_title | Bulletin de la Societe de pathologie exotique (1990) |
| container_volume | 85 |
| creator | DICKEY, R. W BENCSATH, F. A GRANADE, H. R LEWIS, R. J |
| description | Experiments with novel nitrogenous coumarin-based reagents yielded moderately fluorescent derivatives of brevetoxin-3 and ciguatoxin-1. The diethylaminocoumarin-carbamic acid esters of brevetoxin-3 were resolved by high performance liquid chromatography into two derivative peaks that correspond to substitutions at the C-37 and C-41 hydroxyls. The derivatives produced intense molecular ions under fast atom bombardment ionization conditions, confirming derivative identity. Ciguatoxin-1 was also successfully derivatized, resolved, and identified by HPLC-fluorometry with an estimated lower limit of detection of 0.5 to 1.0 ng. |
| format | Article |
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W ; BENCSATH, F. A ; GRANADE, H. R ; LEWIS, R. J</creator><creatorcontrib>DICKEY, R. W ; BENCSATH, F. A ; GRANADE, H. R ; LEWIS, R. J</creatorcontrib><description>Experiments with novel nitrogenous coumarin-based reagents yielded moderately fluorescent derivatives of brevetoxin-3 and ciguatoxin-1. The diethylaminocoumarin-carbamic acid esters of brevetoxin-3 were resolved by high performance liquid chromatography into two derivative peaks that correspond to substitutions at the C-37 and C-41 hydroxyls. The derivatives produced intense molecular ions under fast atom bombardment ionization conditions, confirming derivative identity. Ciguatoxin-1 was also successfully derivatized, resolved, and identified by HPLC-fluorometry with an estimated lower limit of detection of 0.5 to 1.0 ng.</description><identifier>ISSN: 0037-9085</identifier><identifier>EISSN: 1961-9049</identifier><identifier>PMID: 1340357</identifier><identifier>CODEN: BSPEAM</identifier><language>eng</language><publisher>Paris: Société de pathologie exotique</publisher><subject>Animal poisons toxicology. Antivenoms ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Ciguatoxins - analysis ; Coumarins ; Ethers, Cyclic - analysis ; Fluorescent Dyes ; Marine Toxins - analysis ; Medical sciences ; Nigericin - analysis ; Okadaic Acid ; Oxocins ; Spectrometry, Mass, Fast Atom Bombardment ; Toxicology ; Tropical medicine</subject><ispartof>Bulletin de la Societe de pathologie exotique (1990), 1992, Vol.85 (5-BIS), p.514-515</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,4024,4050,4051,23930,23931,25140</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3816857$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1340357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DICKEY, R. W</creatorcontrib><creatorcontrib>BENCSATH, F. A</creatorcontrib><creatorcontrib>GRANADE, H. R</creatorcontrib><creatorcontrib>LEWIS, R. J</creatorcontrib><title>Liquid chromatographic mass spectrometric methods for the determination of marine polyether toxins</title><title>Bulletin de la Societe de pathologie exotique (1990)</title><addtitle>Bull Soc Pathol Exot</addtitle><description>Experiments with novel nitrogenous coumarin-based reagents yielded moderately fluorescent derivatives of brevetoxin-3 and ciguatoxin-1. The diethylaminocoumarin-carbamic acid esters of brevetoxin-3 were resolved by high performance liquid chromatography into two derivative peaks that correspond to substitutions at the C-37 and C-41 hydroxyls. The derivatives produced intense molecular ions under fast atom bombardment ionization conditions, confirming derivative identity. Ciguatoxin-1 was also successfully derivatized, resolved, and identified by HPLC-fluorometry with an estimated lower limit of detection of 0.5 to 1.0 ng.</description><subject>Animal poisons toxicology. Antivenoms</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Ciguatoxins - analysis</subject><subject>Coumarins</subject><subject>Ethers, Cyclic - analysis</subject><subject>Fluorescent Dyes</subject><subject>Marine Toxins - analysis</subject><subject>Medical sciences</subject><subject>Nigericin - analysis</subject><subject>Okadaic Acid</subject><subject>Oxocins</subject><subject>Spectrometry, Mass, Fast Atom Bombardment</subject><subject>Toxicology</subject><subject>Tropical medicine</subject><issn>0037-9085</issn><issn>1961-9049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j09LxDAQxYMo67LuRxBy8FpINk2bHGXxHyx40fMySaY20jY1yYL77Y1YPM3Me795zFyQNdcNrzSr9SVZMyba0it5TbYpfTLGuOK8zCuy4qJmQrZrYg7-6-QdtX0MI-TwEWHuvaUjpETTjDYXHXP8lTD3wSXahUhzj9Rhxjj6CbIPEw1d2Yl-QjqH4VxQLFT49lO6IVcdDAm3S92Q98eHt_1zdXh9etnfH6qZS5YrtbNojdUt0zsJNUhrAJFbWXPABhQyozsjnJBWNs6gbpxWaGyjHZdaotiQ27_c-WRGdMc5-nLR-bj8Wvy7xYdkYegiTNanf0wo3qiC_QCky2Iq</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>DICKEY, R. 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Antivenoms</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Ciguatoxins - analysis</topic><topic>Coumarins</topic><topic>Ethers, Cyclic - analysis</topic><topic>Fluorescent Dyes</topic><topic>Marine Toxins - analysis</topic><topic>Medical sciences</topic><topic>Nigericin - analysis</topic><topic>Okadaic Acid</topic><topic>Oxocins</topic><topic>Spectrometry, Mass, Fast Atom Bombardment</topic><topic>Toxicology</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DICKEY, R. W</creatorcontrib><creatorcontrib>BENCSATH, F. A</creatorcontrib><creatorcontrib>GRANADE, H. R</creatorcontrib><creatorcontrib>LEWIS, R. 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J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liquid chromatographic mass spectrometric methods for the determination of marine polyether toxins</atitle><jtitle>Bulletin de la Societe de pathologie exotique (1990)</jtitle><addtitle>Bull Soc Pathol Exot</addtitle><date>1992</date><risdate>1992</risdate><volume>85</volume><issue>5-BIS</issue><spage>514</spage><epage>515</epage><pages>514-515</pages><issn>0037-9085</issn><eissn>1961-9049</eissn><coden>BSPEAM</coden><abstract>Experiments with novel nitrogenous coumarin-based reagents yielded moderately fluorescent derivatives of brevetoxin-3 and ciguatoxin-1. The diethylaminocoumarin-carbamic acid esters of brevetoxin-3 were resolved by high performance liquid chromatography into two derivative peaks that correspond to substitutions at the C-37 and C-41 hydroxyls. The derivatives produced intense molecular ions under fast atom bombardment ionization conditions, confirming derivative identity. Ciguatoxin-1 was also successfully derivatized, resolved, and identified by HPLC-fluorometry with an estimated lower limit of detection of 0.5 to 1.0 ng.</abstract><cop>Paris</cop><pub>Société de pathologie exotique</pub><pmid>1340357</pmid><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0037-9085 |
| ispartof | Bulletin de la Societe de pathologie exotique (1990), 1992, Vol.85 (5-BIS), p.514-515 |
| issn | 0037-9085 1961-9049 |
| language | eng |
| recordid | cdi_pubmed_primary_1340357 |
| source | MEDLINE; Gallica Periodicals |
| subjects | Animal poisons toxicology. Antivenoms Biological and medical sciences Chromatography, High Pressure Liquid Ciguatoxins - analysis Coumarins Ethers, Cyclic - analysis Fluorescent Dyes Marine Toxins - analysis Medical sciences Nigericin - analysis Okadaic Acid Oxocins Spectrometry, Mass, Fast Atom Bombardment Toxicology Tropical medicine |
| title | Liquid chromatographic mass spectrometric methods for the determination of marine polyether toxins |
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