Isolation of analogues of Okadaic acid from cultures of Prorocentrum lima
A chloroform extract of cultured Prorocentrum lima was analyzed for carboxylic polyethers related to okadaic acid (OA). The extract was derivatized with 1-(bromoacetyl)pyrene to give the fluorescent pyrenacyl esters of OA and other carboxylic acids. The resulting mixture was subjected to preparative...
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| Veröffentlicht in: | Bulletin de la Societe de pathologie exotique (1990) 1992, Vol.85 (5-BIS), p.478-480 |
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| container_issue | 5-BIS |
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| container_title | Bulletin de la Societe de pathologie exotique (1990) |
| container_volume | 85 |
| creator | GRANADE, H. R BENCSATH, F. A DICKEY, R. W |
| description | A chloroform extract of cultured Prorocentrum lima was analyzed for carboxylic polyethers related to okadaic acid (OA). The extract was derivatized with 1-(bromoacetyl)pyrene to give the fluorescent pyrenacyl esters of OA and other carboxylic acids. The resulting mixture was subjected to preparative high performance liquid chromatography with fluorescence detection. Positive chemical ionization mass spectrometry indicated that four OA-related compounds were present, including two methylated analogues. The fragmentation pattern of at least one of these suggests it is not the previously reported 35-methylokadaic acid. |
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The fragmentation pattern of at least one of these suggests it is not the previously reported 35-methylokadaic acid.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dinoflagellida - chemistry</subject><subject>Ethers, Cyclic - isolation & purification</subject><subject>Mass Spectrometry</subject><subject>Medical sciences</subject><subject>Okadaic Acid</subject><subject>Plant poisons toxicology</subject><subject>Toxicology</subject><subject>Tropical medicine</subject><subject>United States Virgin Islands</subject><issn>0037-9085</issn><issn>1961-9049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j09LxDAUxIMoa1n3Iwg5eC3kNUmTHGXxz8LCetDz8po0Um2bkrQHv72RLZ5mht_wHnNFCjA1lIYJc00KxrjKXstbskvpizEGGiDnDdkAF4wLU5DDIYUe5y6MNHiKI_bhc2nTXzh9o8POUrSdoz6Ggdqln5d4oW8xxGDbcY7LQPtuwDty47FP7W7VLfl4fnrfv5bH08th_3gsJ5BsLh1rlRQKWm0r5Rw4AO6ZQYkVc1mslrVuRPbSWiGhUto1XEqF0oDP5S25v9ydlmZo3XmK-Xn8Oa-TMn9YOSaLvY842i7917iGWgvFfwEr7FVv</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>GRANADE, H. 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W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation of analogues of Okadaic acid from cultures of Prorocentrum lima</atitle><jtitle>Bulletin de la Societe de pathologie exotique (1990)</jtitle><addtitle>Bull Soc Pathol Exot</addtitle><date>1992</date><risdate>1992</risdate><volume>85</volume><issue>5-BIS</issue><spage>478</spage><epage>480</epage><pages>478-480</pages><issn>0037-9085</issn><eissn>1961-9049</eissn><coden>BSPEAM</coden><abstract>A chloroform extract of cultured Prorocentrum lima was analyzed for carboxylic polyethers related to okadaic acid (OA). The extract was derivatized with 1-(bromoacetyl)pyrene to give the fluorescent pyrenacyl esters of OA and other carboxylic acids. The resulting mixture was subjected to preparative high performance liquid chromatography with fluorescence detection. Positive chemical ionization mass spectrometry indicated that four OA-related compounds were present, including two methylated analogues. The fragmentation pattern of at least one of these suggests it is not the previously reported 35-methylokadaic acid.</abstract><cop>Paris</cop><pub>Société de pathologie exotique</pub><pmid>1340349</pmid><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0037-9085 |
| ispartof | Bulletin de la Societe de pathologie exotique (1990), 1992, Vol.85 (5-BIS), p.478-480 |
| issn | 0037-9085 1961-9049 |
| language | eng |
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| source | MEDLINE; Gallica Periodicals |
| subjects | Animals Biological and medical sciences Chromatography, High Pressure Liquid Dinoflagellida - chemistry Ethers, Cyclic - isolation & purification Mass Spectrometry Medical sciences Okadaic Acid Plant poisons toxicology Toxicology Tropical medicine United States Virgin Islands |
| title | Isolation of analogues of Okadaic acid from cultures of Prorocentrum lima |
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