On the mechanism of the okadaic acid-induced inhibition of phosphatidylcholine biosynthesis in isolated rat hepatocytes

The mechanism of inhibition of phosphatidylcholine biosynthesis by okadaic acid was investigated in suspension cultures of isolated rat hepatocytes. Cells were pulsed with [methyl-3H]choline and chased in the absence or presence of 1 microM okadaic acid for up to 120 min. Phosphatidylcholine biosynt...

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Veröffentlicht in:	The Journal of biological chemistry 1992-08, Vol.267 (22), p.15751-15758
Hauptverfasser:	HATCH, GM, JAMIL, H, UTAL, AK, VANCE, DE
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biochemistry & Molecular Biology Biological and medical sciences Cell Membrane - enzymology Cells, Cultured Choline - metabolism Choline-Phosphate Cytidylyltransferase Cytosol - enzymology Ethers, Cyclic - pharmacology Fundamental and applied biological sciences. Psychology Glycerolipids, phospholipids Life Sciences & Biomedicine Lipids Liver - drug effects Liver - metabolism Nucleotidyltransferases - metabolism Okadaic Acid Other biological molecules Peptide Mapping Phosphates - metabolism Phosphatidylcholines - biosynthesis Radioisotope Dilution Technique Rats Science & Technology Time Factors Tritium
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