Polar Expression of ErbB-2/HER2 in Epithelia: Bimodal Regulation by Lin-7

ErbB-2/HER2 drives epithelial malignancies by forming heterodimers with growth factor receptors. The primordial invertebrate receptor is sorted to the basolateral epithelial surface by binding of the PDZ domain of Lin-7 to the receptor's tail. We show that all four human ErbBs are basolaterally...

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Veröffentlicht in:	Developmental cell 2003-09, Vol.5 (3), p.475-486
Hauptverfasser:	Shelly, Maya, Mosesson, Yaron, Citri, Ami, Lavi, Sara, Zwang, Yaara, Melamed-Book, Naomi, Aroeti, Benjamin, Yarden, Yosef
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs - physiology Amino Acid Sequence Animals Blotting, Western Caenorhabditis elegans Proteins - physiology Cell Line Cell Polarity Dogs Epithelium - metabolism Humans Kidney Membrane Proteins - physiology Mutation Protein Transport - physiology Receptor, ErbB-2 - biosynthesis Receptor, ErbB-2 - genetics Receptor, ErbB-2 - physiology Subcellular Fractions - metabolism Time Factors Transfection
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