Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells

We examined the effect of PTH-related peptide (PTHrP) on modulating adipogenesis and osteoblastogenesis in the pluripotent mesenchymal cell line C3H10T(1/2). These cells express the type 1 PTH/PTHrP receptor, thereby allowing PTHrP to inhibit bone morphogenetic protein 2 (BMP2) from enhancing gene e...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2003-12, Vol.144 (12), p.5511
Hauptverfasser:	Chan, George K, Miao, Dengshun, Deckelbaum, Ron, Bolivar, Isabel, Karaplis, Andrew, Goltzman, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipocytes - drug effects Animals Bone Morphogenetic Protein 2 Bone Morphogenetic Protein Receptors, Type I Bone Morphogenetic Proteins - pharmacology Cell Line Cell Lineage - drug effects Drug Synergism Gene Expression - drug effects Mesoderm - cytology Mice Mice, Inbred C3H Osteoblasts - cytology Osteoblasts - drug effects Parathyroid Hormone-Related Protein - pharmacology Pluripotent Stem Cells - cytology Pluripotent Stem Cells - drug effects Pluripotent Stem Cells - metabolism Protein Kinase C - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Receptor, Parathyroid Hormone, Type 1 - genetics Receptor, Parathyroid Hormone, Type 1 - metabolism Receptors, Growth Factor - genetics Receptors, Growth Factor - metabolism Signal Transduction - drug effects Transforming Growth Factor beta Up-Regulation - drug effects
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