Transgenic Models of Metabolic Bone Disease: Impact of Estrogen Receptor Deficiency on Skeletal Metabolism

Estrogen has protective effects on the skeleton via its inhibition of bone resorption. Mechanisms for these effects and the selectivity to the estrogen receptor &#102 (ER &#102 ) or ER &#103 are unclear. The purpose of our study was to determine the impact of the ER &#102 on skeletal...

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Veröffentlicht in:	Connective tissue research 2003, Vol.44 (1), p.250-263
Hauptverfasser:	McCauley, L. K., Tözüm, T. F., Kozloff, K. M., Koh-Paige, A. J., Chen, C., Demashkieh, M., Cronovich, H., Richard, V., Keller, E. T., Rosol, T. J., Goldstein, S. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Animals Bone Bone and Bones - diagnostic imaging Bone and Bones - metabolism Bone and Bones - pathology Bone Density Bone Diseases, Metabolic - genetics Bone Diseases, Metabolic - metabolism Bone Diseases, Metabolic - pathology Calcification, Physiologic - physiology Disease Models, Animal Estrogen Estrogen Receptor Estrogen Receptor alpha Estrogen Receptor beta Female Femur - diagnostic imaging Femur - metabolism Femur - pathology Male Mice Mice, Knockout Mice, Transgenic Osteoblasts Osteoblasts - metabolism Osteoblasts - pathology Receptors, Estrogen - deficiency Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Sex Factors Tibia - diagnostic imaging Tibia - metabolism Tibia - pathology
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