A New Approach in Gastroretentive Drug Delivery System Using Cholestyramine

We prepared cellulose acetate butyrate (CAB)-coated cholestyramine microcapsules as a intragastric floating drug delivery system endowed with floating ability due to the carbon dioxide generation when exposed to the gastric fluid. The microcapsules also have a mucoadhesive property. Ion-exchange res...

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Veröffentlicht in:	Drug delivery 2003, Vol.10 (3), p.151-160
Hauptverfasser:	Umamaheshwari, R. B., Jain, Subheet, Jain, N. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetohydroxamic Acid Adhesives - chemistry Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Capsules Cellulose - analogs & derivatives Cellulose - chemistry Chemistry, Pharmaceutical Cholestyramine Cholestyramine Resin - chemistry Digestive System Drug Delivery Systems Floating Microcapsules Helicobacter Pylori Hydroxamic Acids - administration & dosage Hydroxamic Acids - chemistry Mucoadhesion Particle Size Sodium Bicarbonate - administration & dosage Sodium Bicarbonate - chemistry Solubility Surface Properties Urease - antagonists & inhibitors
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