Pharmacodynamic Response and Inhibition of Growth of Human Tumor Xenografts by the Novel Histone Deacetylase Inhibitor PXD101

Histone acetylation has a central role in the control of gene expression, influencing transcriptional control of many genes, including tumor suppressor genes. PXD101 is a novel hydroxamate-type inhibitor of histone deacetylase activity that inhibits histone deacetylase activity in HeLa cell extracts...

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Veröffentlicht in:	Molecular cancer therapeutics 2003-08, Vol.2 (8), p.721
Hauptverfasser:	Plumb, Jane A, Finn, Paul W, Williams, Robert J, Bandara, Morwenna J, Romero, M Rosario, Watkins, Claire J, La Thangue, Nicholas B, Brown, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Animals Apoptosis Cell Line, Tumor Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology HeLa Cells Histone Deacetylase Inhibitors Histone Deacetylases - metabolism Histones - metabolism Humans Hydroxamic Acids Mice Mice, Nude Neoplasms, Experimental - drug therapy Structure-Activity Relationship Sulfonamides Transplantation, Heterologous Xenograft Model Antitumor Assays
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