Estrogen Decreases the Sensitivity of Anterior Pituitary to the Inhibitory Effect of Nitric Oxide on Prolactin Release
Objective: We investigated the effect of chronic estrogen treatment on the inhibitory action of nitric oxide (NO) on prolactin release. Methods: The effect of NO on prolactin release was studied in anterior pituitaries of female Wistar rats, intact at random stages, ovariectomized (OVX), and OVX tre...
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| Veröffentlicht in: | Hormone research 2003-01, Vol.60 (3), p.111-115 |
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| creator | Velardez, Miguel Omar del Carmen Díaz, María Lasaga, Mercedes Franchi, Ana María Duvilanski, Beatriz Haydée |
| description | Objective: We investigated the effect of chronic estrogen treatment on the inhibitory action of nitric oxide (NO) on prolactin release. Methods: The effect of NO on prolactin release was studied in anterior pituitaries of female Wistar rats, intact at random stages, ovariectomized (OVX), and OVX treated for 15 days with 17β-estradiol (OVX-E 2 ). Results: Sodium nitroprusside (NP, 0.5 mM), a NO donor, inhibited prolactin release from anterior pituitaries and was able to stimulate cGMP synthesis in intact and OVX rats. Only a high, supraphysiological concentration of NP (2 mM) inhibited prolactin release from anterior pituitaries of OVX-E 2 rats and increased cGMP synthesis in OVX-E 2 rats. 8-Br-cGMP, a cGMP analogue, decreased prolactin release from anterior pituitaries of OVX rats but did not affect it in OVX-E 2 rats. Conclusion: Our results suggest that estrogen may modify the sensitivity of the anterior pituitary to the inhibitory effect of NO on prolactin release by affecting guanylyl cyclase activity and the cGMP pathway. |
| doi_str_mv | 10.1159/000072521 |
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Methods: The effect of NO on prolactin release was studied in anterior pituitaries of female Wistar rats, intact at random stages, ovariectomized (OVX), and OVX treated for 15 days with 17β-estradiol (OVX-E 2 ). Results: Sodium nitroprusside (NP, 0.5 mM), a NO donor, inhibited prolactin release from anterior pituitaries and was able to stimulate cGMP synthesis in intact and OVX rats. Only a high, supraphysiological concentration of NP (2 mM) inhibited prolactin release from anterior pituitaries of OVX-E 2 rats and increased cGMP synthesis in OVX-E 2 rats. 8-Br-cGMP, a cGMP analogue, decreased prolactin release from anterior pituitaries of OVX rats but did not affect it in OVX-E 2 rats. Conclusion: Our results suggest that estrogen may modify the sensitivity of the anterior pituitary to the inhibitory effect of NO on prolactin release by affecting guanylyl cyclase activity and the cGMP pathway.</description><identifier>ISSN: 1663-2818</identifier><identifier>ISSN: 0301-0163</identifier><identifier>EISSN: 1663-2826</identifier><identifier>DOI: 10.1159/000072521</identifier><identifier>PMID: 12931037</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Animals ; Cyclic GMP - analogs & derivatives ; Cyclic GMP - metabolism ; Cyclic GMP - pharmacology ; Dose-Response Relationship, Drug ; Estradiol - pharmacology ; Female ; Nitric Oxide - pharmacology ; Nitric Oxide Synthase - metabolism ; Nitroprusside - administration & dosage ; Original Paper ; Osmolar Concentration ; Ovariectomy ; Pituitary Gland, Anterior - drug effects ; Pituitary Gland, Anterior - metabolism ; Prolactin - antagonists & inhibitors ; Rats ; Rats, Wistar</subject><ispartof>Hormone research, 2003-01, Vol.60 (3), p.111-115</ispartof><rights>2003 S. Karger AG, Basel</rights><rights>Copyright 2003 S. Karger AG, Basel</rights><rights>Copyright (c) 2003 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-d89ba9b51fff4e4d5a26e7d7d6c237c223bc72f6d916927bcc58f3bb4363660d3</citedby><cites>FETCH-LOGICAL-c356t-d89ba9b51fff4e4d5a26e7d7d6c237c223bc72f6d916927bcc58f3bb4363660d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12931037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Velardez, Miguel Omar</creatorcontrib><creatorcontrib>del Carmen Díaz, María</creatorcontrib><creatorcontrib>Lasaga, Mercedes</creatorcontrib><creatorcontrib>Franchi, Ana María</creatorcontrib><creatorcontrib>Duvilanski, Beatriz Haydée</creatorcontrib><title>Estrogen Decreases the Sensitivity of Anterior Pituitary to the Inhibitory Effect of Nitric Oxide on Prolactin Release</title><title>Hormone research</title><addtitle>Horm Res Paediatr</addtitle><description>Objective: We investigated the effect of chronic estrogen treatment on the inhibitory action of nitric oxide (NO) on prolactin release. Methods: The effect of NO on prolactin release was studied in anterior pituitaries of female Wistar rats, intact at random stages, ovariectomized (OVX), and OVX treated for 15 days with 17β-estradiol (OVX-E 2 ). Results: Sodium nitroprusside (NP, 0.5 mM), a NO donor, inhibited prolactin release from anterior pituitaries and was able to stimulate cGMP synthesis in intact and OVX rats. Only a high, supraphysiological concentration of NP (2 mM) inhibited prolactin release from anterior pituitaries of OVX-E 2 rats and increased cGMP synthesis in OVX-E 2 rats. 8-Br-cGMP, a cGMP analogue, decreased prolactin release from anterior pituitaries of OVX rats but did not affect it in OVX-E 2 rats. Conclusion: Our results suggest that estrogen may modify the sensitivity of the anterior pituitary to the inhibitory effect of NO on prolactin release by affecting guanylyl cyclase activity and the cGMP pathway.</description><subject>Animals</subject><subject>Cyclic GMP - analogs & derivatives</subject><subject>Cyclic GMP - metabolism</subject><subject>Cyclic GMP - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Nitric Oxide - pharmacology</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Nitroprusside - administration & dosage</subject><subject>Original Paper</subject><subject>Osmolar Concentration</subject><subject>Ovariectomy</subject><subject>Pituitary Gland, Anterior - drug effects</subject><subject>Pituitary Gland, Anterior - metabolism</subject><subject>Prolactin - antagonists & inhibitors</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>1663-2818</issn><issn>0301-0163</issn><issn>1663-2826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpt0c9LwzAUB_AgisrcwbMgQUHwMG2SNWmPQ6cOhsrUc2mTlxntmpmkov-92Q8miLkkhA_f93gPoUOSXBCS5pdJPIKmlGyhfcI569GM8u3Nm2R7qOv924KxTORE7KI9QnNGEib20efQB2en0OBrkA5KDx6HV8BP0HgTzKcJ39hqPGgCOGMdfjShNaF03zjYJRw1r6YywcafodYgw4Lfm-CMxA9fRgG2DX50ti5lMA2eQL0ocoB2dFl76K7vDnq5GT5f3fXGD7ejq8G4J1nKQ09leVXmVUq01n3oq7SkHIQSikvKhKSUVVJQzVVOeE5FJWWaaVZVfcYZ54liHXS2yp07-9GCD8XMeAl1XTZgW18IlmY0T0SEp3_gm21dE3srSBKzGSFxfh10vlLSWe8d6GLuzCxOI6JisY1is41oj9eJbTUD9SvXs4_gZAXeSzcFtwF3k-EyoZgrHdHRv2hV4wc_2Zj7</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Velardez, Miguel Omar</creator><creator>del Carmen Díaz, María</creator><creator>Lasaga, Mercedes</creator><creator>Franchi, Ana María</creator><creator>Duvilanski, Beatriz Haydée</creator><general>S. 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del Carmen Díaz, María ; Lasaga, Mercedes ; Franchi, Ana María ; Duvilanski, Beatriz Haydée</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-d89ba9b51fff4e4d5a26e7d7d6c237c223bc72f6d916927bcc58f3bb4363660d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Cyclic GMP - analogs & derivatives</topic><topic>Cyclic GMP - metabolism</topic><topic>Cyclic GMP - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Nitric Oxide - pharmacology</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Nitroprusside - administration & dosage</topic><topic>Original Paper</topic><topic>Osmolar Concentration</topic><topic>Ovariectomy</topic><topic>Pituitary Gland, Anterior - drug effects</topic><topic>Pituitary Gland, Anterior - metabolism</topic><topic>Prolactin - antagonists & inhibitors</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Velardez, Miguel Omar</creatorcontrib><creatorcontrib>del Carmen Díaz, María</creatorcontrib><creatorcontrib>Lasaga, Mercedes</creatorcontrib><creatorcontrib>Franchi, Ana María</creatorcontrib><creatorcontrib>Duvilanski, Beatriz Haydée</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Velardez, Miguel Omar</au><au>del Carmen Díaz, María</au><au>Lasaga, Mercedes</au><au>Franchi, Ana María</au><au>Duvilanski, Beatriz Haydée</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estrogen Decreases the Sensitivity of Anterior Pituitary to the Inhibitory Effect of Nitric Oxide on Prolactin Release</atitle><jtitle>Hormone research</jtitle><addtitle>Horm Res Paediatr</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>60</volume><issue>3</issue><spage>111</spage><epage>115</epage><pages>111-115</pages><issn>1663-2818</issn><issn>0301-0163</issn><eissn>1663-2826</eissn><abstract>Objective: We investigated the effect of chronic estrogen treatment on the inhibitory action of nitric oxide (NO) on prolactin release. Methods: The effect of NO on prolactin release was studied in anterior pituitaries of female Wistar rats, intact at random stages, ovariectomized (OVX), and OVX treated for 15 days with 17β-estradiol (OVX-E 2 ). Results: Sodium nitroprusside (NP, 0.5 mM), a NO donor, inhibited prolactin release from anterior pituitaries and was able to stimulate cGMP synthesis in intact and OVX rats. Only a high, supraphysiological concentration of NP (2 mM) inhibited prolactin release from anterior pituitaries of OVX-E 2 rats and increased cGMP synthesis in OVX-E 2 rats. 8-Br-cGMP, a cGMP analogue, decreased prolactin release from anterior pituitaries of OVX rats but did not affect it in OVX-E 2 rats. Conclusion: Our results suggest that estrogen may modify the sensitivity of the anterior pituitary to the inhibitory effect of NO on prolactin release by affecting guanylyl cyclase activity and the cGMP pathway.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>12931037</pmid><doi>10.1159/000072521</doi><tpages>5</tpages></addata></record> |
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| ispartof | Hormone research, 2003-01, Vol.60 (3), p.111-115 |
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| source | Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Cyclic GMP - analogs & derivatives Cyclic GMP - metabolism Cyclic GMP - pharmacology Dose-Response Relationship, Drug Estradiol - pharmacology Female Nitric Oxide - pharmacology Nitric Oxide Synthase - metabolism Nitroprusside - administration & dosage Original Paper Osmolar Concentration Ovariectomy Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Prolactin - antagonists & inhibitors Rats Rats, Wistar |
| title | Estrogen Decreases the Sensitivity of Anterior Pituitary to the Inhibitory Effect of Nitric Oxide on Prolactin Release |
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