Sequential recognition of two distinct sites in sigma(S) by the proteolytic targeting factor RssB and ClpX

sigma(S) (RpoS), the master regulator of the general stress response in Escherichia coli, is a model system for regulated proteolysis in bacteria. sigma(S) turnover requires ClpXP and the response regulator RssB, whose phosphorylated form exhibits high affinity for sigma(S). Here, we demonstrate tha...

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Veröffentlicht in:	The EMBO journal 2003-08, Vol.22 (16), p.4111
Hauptverfasser:	Stüdemann, Andrea, Noirclerc-Savoye, Marjolaine, Klauck, Eberhard, Becker, Gisela, Schneider, Dominique, Hengge, Regine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - metabolism Alanine - metabolism Amino Acid Substitution Binding Sites DNA-Binding Proteins - isolation & purification DNA-Binding Proteins - metabolism Escherichia coli - chemistry Escherichia coli - metabolism Escherichia coli Proteins - isolation & purification Escherichia coli Proteins - metabolism Gene Expression Regulation, Bacterial Molecular Chaperones - chemistry Molecular Chaperones - metabolism Mutagenesis, Site-Directed Phosphorylation Point Mutation Protein Binding Protein Structure, Secondary Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Sigma Factor - chemistry Sigma Factor - genetics Sigma Factor - metabolism Transcription Factors - isolation & purification Transcription Factors - metabolism
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