Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein

Skp2 is the F-box protein component of an SCF-type ubiquitin ligase that interacts specifically with p27(Kip1) and thereby promotes its ubiquitylation and degradation. The abundance of Skp2 mRNA oscillates in a cell cycle-dependent manner, being maximal in S and G(2) phases. The regulation of Skp2 t...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-08, Vol.63 (15), p.4607-4613
Hauptverfasser:	IMAKI, Hiroyuki, NAKAYAMA, Keiko, DELEHOUZEE, Sophie, HANDA, Hiroshi, KITAGAWA, Masatoshi, KAMURA, Takumi, NAKAYAMA, Keiichi I
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Base Sequence Biological and medical sciences Cell Cycle - genetics Cell Cycle - physiology Cell Cycle Proteins - biosynthesis Cell Cycle Proteins - genetics Cell metabolism, cell oxidation Cell physiology DNA - genetics DNA - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Fundamental and applied biological sciences. Psychology GA-Binding Protein Transcription Factor Gene Expression Regulation Genes, Regulator HeLa Cells Humans Mice Molecular and cellular biology Molecular Sequence Data Promoter Regions, Genetic RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Small Interfering - genetics S-Phase Kinase-Associated Proteins Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology
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