Nonclinical safety evaluation of Escherichia coli heat-labile toxin mucosal adjuvant as a component of a nasal influenza vaccine

Conventional influenza vaccines currently in use are administered parenterally and generally confer good protection against systemic disease through the induction of high titers of serum virus-neutralizing antibodies. Parenteral vaccines are suboptimal in that they fail to induce a local mucosal res...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Expert review of vaccines 2003-04, Vol.2 (2), p.295-304
Hauptverfasser:	Zurbriggen, Rinaldo, Metcalfe, Ian C, Glück, Reinhard, Viret, Jean-François, Moser, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - pharmacokinetics Adjuvants, Immunologic - toxicity Administration, Intranasal Animals Antibodies Antigens Bacterial Toxins - administration & dosage Bacterial Toxins - pharmacokinetics Bacterial Toxins - toxicity Bell Palsy - etiology Enterotoxins - administration & dosage Enterotoxins - pharmacokinetics Enterotoxins - toxicity Escherichia coli Escherichia coli Proteins Ferrets Health aspects heat-labile toxin Humans Immune response Immunity, Mucosal Infection Influenza influenza vaccine Influenza vaccines Influenza Vaccines - administration & dosage Influenza Vaccines - pharmacokinetics Influenza Vaccines - toxicity intranasal Intranasal administration LTadjuvant Mice Mucosa mucosal Olfactory Bulb - metabolism Papio Rabbits Rats Reviews Safety Safety and security measures Swine Swine, Miniature Toxins Vaccines Virus Diseases - etiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!