Effect of oral adsorbent (AST-120) in the rat model of chronic renal failure induced by adriamycin
The effect of AST-120 was examined in the rat model of CRF induced by adriamycin (ADM), which is known to induce focal glomerular sclerosis (GS). ADM (2mg/kg) was injected intravenously twice at a 3-wk interval. After 14 wks, rats were paired with control (C) and AST-120 (A) groups according to leve...
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| Veröffentlicht in: | Nihon Jinzo Gakkai shi 1992/10/25, Vol.34(10), pp.1055-1059 |
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| container_issue | 10 |
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| container_title | Nihon Jinzo Gakkai shi |
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| creator | YOSHIDA, YOSHIVUKI ISE, MICHIHITO |
| description | The effect of AST-120 was examined in the rat model of CRF induced by adriamycin (ADM), which is known to induce focal glomerular sclerosis (GS). ADM (2mg/kg) was injected intravenously twice at a 3-wk interval. After 14 wks, rats were paired with control (C) and AST-120 (A) groups according to levels of BUN and proteinuria. Then, the rats were fed regular rat chow with (A, n=1O) or without (C, n10) AST-120. After 28 wks, there were more GS in C. Averaged sclerosis index(SI, 0-4scale) in C was 1.97 (0.94-3.22), while 1.61 (0.60-2.97) in A. When GS was advanced in C (SI>2.0), largely ameliorated SI was noted in A (2.61 vs.1.97, C vs.A, p |
| doi_str_mv | 10.14842/jpnjnephrol1959.34.1055 |
| format | Article |
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ADM (2mg/kg) was injected intravenously twice at a 3-wk interval. After 14 wks, rats were paired with control (C) and AST-120 (A) groups according to levels of BUN and proteinuria. Then, the rats were fed regular rat chow with (A, n=1O) or without (C, n10) AST-120. After 28 wks, there were more GS in C. Averaged sclerosis index(SI, 0-4scale) in C was 1.97 (0.94-3.22), while 1.61 (0.60-2.97) in A. When GS was advanced in C (SI>2.0), largely ameliorated SI was noted in A (2.61 vs.1.97, C vs.A, p<0.05 by paired W-test, n=5 each). Also, in these rats, BUN, serum creatinine and Ht were all improved in A (p<0. 05). Thus, AST-120 was effective in CRF rats induced by ADM when uremia was advanced. The data also indicates that a reduction of uremic toxins could improve glomerular histology and renal function in CRF.</description><identifier>ISSN: 0385-2385</identifier><identifier>EISSN: 1884-0728</identifier><identifier>DOI: 10.14842/jpnjnephrol1959.34.1055</identifier><identifier>PMID: 1289605</identifier><language>jpn</language><publisher>Japan: Japanese Society of Nephrology</publisher><subject>Animals ; Carbon - therapeutic use ; Disease Models, Animal ; Doxorubicin ; Female ; Kidney - pathology ; Kidney Failure, Chronic - chemically induced ; Kidney Failure, Chronic - drug therapy ; Kidney Failure, Chronic - pathology ; oral adsorbent, chronic renal failure, uremia, adriamycin, glomerular sclerosis ; Oxides - therapeutic use ; Rats ; Rats, Wistar ; Sclerosis</subject><ispartof>The Japanese Journal of Nephrology, 1992/10/25, Vol.34(10), pp.1055-1059</ispartof><rights>Japanese Society of Nephrology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1289605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YOSHIDA, YOSHIVUKI</creatorcontrib><creatorcontrib>ISE, MICHIHITO</creatorcontrib><title>Effect of oral adsorbent (AST-120) in the rat model of chronic renal failure induced by adriamycin</title><title>Nihon Jinzo Gakkai shi</title><addtitle>Jpn J Nephrol</addtitle><description>The effect of AST-120 was examined in the rat model of CRF induced by adriamycin (ADM), which is known to induce focal glomerular sclerosis (GS). ADM (2mg/kg) was injected intravenously twice at a 3-wk interval. After 14 wks, rats were paired with control (C) and AST-120 (A) groups according to levels of BUN and proteinuria. Then, the rats were fed regular rat chow with (A, n=1O) or without (C, n10) AST-120. After 28 wks, there were more GS in C. Averaged sclerosis index(SI, 0-4scale) in C was 1.97 (0.94-3.22), while 1.61 (0.60-2.97) in A. When GS was advanced in C (SI>2.0), largely ameliorated SI was noted in A (2.61 vs.1.97, C vs.A, p<0.05 by paired W-test, n=5 each). Also, in these rats, BUN, serum creatinine and Ht were all improved in A (p<0. 05). Thus, AST-120 was effective in CRF rats induced by ADM when uremia was advanced. The data also indicates that a reduction of uremic toxins could improve glomerular histology and renal function in CRF.</description><subject>Animals</subject><subject>Carbon - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Doxorubicin</subject><subject>Female</subject><subject>Kidney - pathology</subject><subject>Kidney Failure, Chronic - chemically induced</subject><subject>Kidney Failure, Chronic - drug therapy</subject><subject>Kidney Failure, Chronic - pathology</subject><subject>oral adsorbent, chronic renal failure, uremia, adriamycin, glomerular sclerosis</subject><subject>Oxides - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sclerosis</subject><issn>0385-2385</issn><issn>1884-0728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkD9vwjAQxa2qFUWUj1DJYzuE2o6N7REh-kdC7VA6R45zLo4SJ3LCwLevEYihy93wfvfu7iGEKVlQrjh7qftQB-j3sWuoFnqR8wUlQtygKVWKZ0QydYumJFciY6nco_kw-JJQJUkuJJ-gCWVKL4mYonLjHNgRdw530TTYVEMXSwgjflp97zLKyDP2AY97wNGMuO0qaE6wTcuDtzhCSFPO-OYQIZHVwUKFy2Myit60R-vDA7pzphlgfukz9PO62a3fs-3X28d6tc1qxvWYMSCGG8NFulMzqZQlS2elFYxp7pjThDmpy6UruZFaSQkiwZUUDIzKaZnP0OPZtz-ULVRFH31r4rG4_Jr0z7NeD6P5hatu4uhtA8W_VIucF5Rc6ineK2j3JhYQ8j_-iHVC</recordid><startdate>199210</startdate><enddate>199210</enddate><creator>YOSHIDA, YOSHIVUKI</creator><creator>ISE, MICHIHITO</creator><general>Japanese Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199210</creationdate><title>Effect of oral adsorbent (AST-120) in the rat model of chronic renal failure induced by adriamycin</title><author>YOSHIDA, YOSHIVUKI ; ISE, MICHIHITO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j249t-2e0a4aa4501892788c06fc7c52294f2f902f79b6fb4a79877e5a45d752ea831b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Carbon - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Doxorubicin</topic><topic>Female</topic><topic>Kidney - pathology</topic><topic>Kidney Failure, Chronic - chemically induced</topic><topic>Kidney Failure, Chronic - drug therapy</topic><topic>Kidney Failure, Chronic - pathology</topic><topic>oral adsorbent, chronic renal failure, uremia, adriamycin, glomerular sclerosis</topic><topic>Oxides - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sclerosis</topic><toplevel>online_resources</toplevel><creatorcontrib>YOSHIDA, YOSHIVUKI</creatorcontrib><creatorcontrib>ISE, MICHIHITO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Nihon Jinzo Gakkai shi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YOSHIDA, YOSHIVUKI</au><au>ISE, MICHIHITO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of oral adsorbent (AST-120) in the rat model of chronic renal failure induced by adriamycin</atitle><jtitle>Nihon Jinzo Gakkai shi</jtitle><addtitle>Jpn J Nephrol</addtitle><date>1992-10</date><risdate>1992</risdate><volume>34</volume><issue>10</issue><spage>1055</spage><epage>1059</epage><pages>1055-1059</pages><issn>0385-2385</issn><eissn>1884-0728</eissn><abstract>The effect of AST-120 was examined in the rat model of CRF induced by adriamycin (ADM), which is known to induce focal glomerular sclerosis (GS). ADM (2mg/kg) was injected intravenously twice at a 3-wk interval. After 14 wks, rats were paired with control (C) and AST-120 (A) groups according to levels of BUN and proteinuria. Then, the rats were fed regular rat chow with (A, n=1O) or without (C, n10) AST-120. After 28 wks, there were more GS in C. Averaged sclerosis index(SI, 0-4scale) in C was 1.97 (0.94-3.22), while 1.61 (0.60-2.97) in A. When GS was advanced in C (SI>2.0), largely ameliorated SI was noted in A (2.61 vs.1.97, C vs.A, p<0.05 by paired W-test, n=5 each). Also, in these rats, BUN, serum creatinine and Ht were all improved in A (p<0. 05). Thus, AST-120 was effective in CRF rats induced by ADM when uremia was advanced. The data also indicates that a reduction of uremic toxins could improve glomerular histology and renal function in CRF.</abstract><cop>Japan</cop><pub>Japanese Society of Nephrology</pub><pmid>1289605</pmid><doi>10.14842/jpnjnephrol1959.34.1055</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0385-2385 |
| ispartof | The Japanese Journal of Nephrology, 1992/10/25, Vol.34(10), pp.1055-1059 |
| issn | 0385-2385 1884-0728 |
| language | jpn |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Carbon - therapeutic use Disease Models, Animal Doxorubicin Female Kidney - pathology Kidney Failure, Chronic - chemically induced Kidney Failure, Chronic - drug therapy Kidney Failure, Chronic - pathology oral adsorbent, chronic renal failure, uremia, adriamycin, glomerular sclerosis Oxides - therapeutic use Rats Rats, Wistar Sclerosis |
| title | Effect of oral adsorbent (AST-120) in the rat model of chronic renal failure induced by adriamycin |
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