IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction

Departments of 1 Pediatrics, 2 Molecular Biology, and 3 Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas 75390; and 4 Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210 Submitted 26 July 2001 ; accepted in final form 21 April 2003 Myocard...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2003-08, Vol.285 (2), p.H597-H606
Hauptverfasser:	Thomas, James A, Haudek, Sandra B, Koroglu, Tolga, Tsen, May F, Bryant, Debora D, White, D. Jean, Kusewitt, Donna F, Horton, Jureta W, Giroir, Brett P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Chronic Disease Female Heart Failure - metabolism Heart Failure - mortality Heart Failure - physiopathology Interleukin-1 - metabolism Interleukin-1 Receptor-Associated Kinases Lipopolysaccharides - pharmacology Male Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Myocardial Contraction Myocarditis - metabolism Myocarditis - mortality Myocarditis - physiopathology Protein Kinases - genetics Protein Kinases - metabolism Receptors, Cell Surface - metabolism Signal Transduction - physiology Survival Rate Toll-Like Receptors Tumor Necrosis Factor-alpha - genetics
Online-Zugang:	Volltext
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