Screening for hepatocarcinoma in a cohort with cirrhosis mainly of alcoholic origin
To assess the feasibility and efficiency of the screening for hepatocarcinoma in a cohort of cirrhoseis mainly of alcoholic origin. 293 patients with cirrhosis, among them 186 (63.5%) from alcoholic origin, were included in a surveillance programme for hepatocarcinoma by carrying out liver ultrasono...
Gespeichert in:
| Veröffentlicht in: | Gastroentérologie clinique et biologique 2003-05, Vol.27 (5), p.534 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | fre |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | 534 |
| container_title | Gastroentérologie clinique et biologique |
| container_volume | 27 |
| creator | Henrion, Jean Libon, Ernest De Maeght, Stéphane Deltenre, Pierre Schapira, Michaël Ghilain, Jean-Michel Maisin, Jean-Marc Heller, Francis R |
| description | To assess the feasibility and efficiency of the screening for hepatocarcinoma in a cohort of cirrhoseis mainly of alcoholic origin.
293 patients with cirrhosis, among them 186 (63.5%) from alcoholic origin, were included in a surveillance programme for hepatocarcinoma by carrying out liver ultrasonography and alpha-foetoprotein dosage every 6 months. Results were analyzed with a mean follow-up of 60 months. Seventeen hepatocarcinoma discovered through the surveillance programme ("screened HCC") were compared with 40 hepatocarcinoma discovered outside the surveillance programme during the same period ("incidental HCC").
The alcoholic origin of the cirrhosis was a predictive factor of poor compliance to the surveillance programme. Among the 186 patients with alcoholic cirrhosis, 129 (69%) were lost during the surveillance programme due to lack of compliance (97 cases) or death (32 cases). By comparison, among the 65 patients with hepatitis C-related cirrhosis, 18 were lost by lack of compliance (11 cases) or death (7 cases) (P |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_12843918</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>12843918</sourcerecordid><originalsourceid>FETCH-LOGICAL-p139t-cd4fc788b546cffbc68f8556510079d63efe2d3b26f52a08991709f27a067cc3</originalsourceid><addsrcrecordid>eNo1j8tKw0AUhmeh2Fp9BTkvEJhLMpelFG9Q6KLdl8nJTHMkmQmTiPTtVdTVv_n4-P4rtubKucoqyVfsdp7fOefWGXHDVkLaWjlh1-xwwBJConSGmAv0YfJLRl-QUh49UAIPmPtcFvikpQekUvo80wyjpzRcIEfwww8xEEIudKZ0x66jH-Zw_7cbdnx-Om5fq93-5W37uKsmodxSYVdHNNa2Ta0xxha1jbZpdCM4N67TKsQgO9VKHRvpv9OdMNxFaTzXBlFt2MOvdvpox9CdpkKjL5fT_zn1BcsYS2Q</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Screening for hepatocarcinoma in a cohort with cirrhosis mainly of alcoholic origin</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Henrion, Jean ; Libon, Ernest ; De Maeght, Stéphane ; Deltenre, Pierre ; Schapira, Michaël ; Ghilain, Jean-Michel ; Maisin, Jean-Marc ; Heller, Francis R</creator><creatorcontrib>Henrion, Jean ; Libon, Ernest ; De Maeght, Stéphane ; Deltenre, Pierre ; Schapira, Michaël ; Ghilain, Jean-Michel ; Maisin, Jean-Marc ; Heller, Francis R</creatorcontrib><description>To assess the feasibility and efficiency of the screening for hepatocarcinoma in a cohort of cirrhoseis mainly of alcoholic origin.
293 patients with cirrhosis, among them 186 (63.5%) from alcoholic origin, were included in a surveillance programme for hepatocarcinoma by carrying out liver ultrasonography and alpha-foetoprotein dosage every 6 months. Results were analyzed with a mean follow-up of 60 months. Seventeen hepatocarcinoma discovered through the surveillance programme ("screened HCC") were compared with 40 hepatocarcinoma discovered outside the surveillance programme during the same period ("incidental HCC").
The alcoholic origin of the cirrhosis was a predictive factor of poor compliance to the surveillance programme. Among the 186 patients with alcoholic cirrhosis, 129 (69%) were lost during the surveillance programme due to lack of compliance (97 cases) or death (32 cases). By comparison, among the 65 patients with hepatitis C-related cirrhosis, 18 were lost by lack of compliance (11 cases) or death (7 cases) (P<0.001). Moreover, sustained or relapsing alcohol abuse after inclusion in the surveillance programme were also related to the quality of the compliance. Seventeen hepatocarcinoma were discovered through the surveillance giving an annual incidence of 2% for the emergence of hepatocarcinoma. The comparison between screened (n=17) and incidental (n=40) hepatocarcinoma showed that screened HCC were more often asymptomatic (P<0.01), were more often a solitary nodule less than 5 cms (P<0.001) and underwent more often curative treatment (P=0.02). However, the survival between screened and incidental hepatocarcinoma was not different.
Screening for hepatocarcinoma in patients with alcoholic cirrhosis is a difficult task due to poor compliance and early death. According to our results, a surveillance every 6 months is sufficient to detect early lesions accessible to curative treatment by surgical resection or transcutaneous ablation.</description><identifier>ISSN: 0399-8320</identifier><identifier>PMID: 12843918</identifier><language>fre</language><publisher>France</publisher><subject>Aged ; Aged, 80 and over ; alpha-Fetoproteins - metabolism ; Biopsy ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - mortality ; Cohort Studies ; Feasibility Studies ; Female ; Hepatitis C - complications ; Humans ; Liver Cirrhosis - complications ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - virology ; Liver Cirrhosis, Alcoholic - complications ; Liver Cirrhosis, Alcoholic - diagnosis ; Liver Neoplasms - blood ; Liver Neoplasms - diagnosis ; Liver Neoplasms - etiology ; Liver Neoplasms - mortality ; Male ; Mass Screening - methods ; Mass Screening - psychology ; Mass Screening - standards ; Middle Aged ; Patient Compliance - psychology ; Prognosis ; Risk Factors ; Survival Analysis ; Ultrasonography - methods ; Ultrasonography - standards</subject><ispartof>Gastroentérologie clinique et biologique, 2003-05, Vol.27 (5), p.534</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12843918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henrion, Jean</creatorcontrib><creatorcontrib>Libon, Ernest</creatorcontrib><creatorcontrib>De Maeght, Stéphane</creatorcontrib><creatorcontrib>Deltenre, Pierre</creatorcontrib><creatorcontrib>Schapira, Michaël</creatorcontrib><creatorcontrib>Ghilain, Jean-Michel</creatorcontrib><creatorcontrib>Maisin, Jean-Marc</creatorcontrib><creatorcontrib>Heller, Francis R</creatorcontrib><title>Screening for hepatocarcinoma in a cohort with cirrhosis mainly of alcoholic origin</title><title>Gastroentérologie clinique et biologique</title><addtitle>Gastroenterol Clin Biol</addtitle><description>To assess the feasibility and efficiency of the screening for hepatocarcinoma in a cohort of cirrhoseis mainly of alcoholic origin.
293 patients with cirrhosis, among them 186 (63.5%) from alcoholic origin, were included in a surveillance programme for hepatocarcinoma by carrying out liver ultrasonography and alpha-foetoprotein dosage every 6 months. Results were analyzed with a mean follow-up of 60 months. Seventeen hepatocarcinoma discovered through the surveillance programme ("screened HCC") were compared with 40 hepatocarcinoma discovered outside the surveillance programme during the same period ("incidental HCC").
The alcoholic origin of the cirrhosis was a predictive factor of poor compliance to the surveillance programme. Among the 186 patients with alcoholic cirrhosis, 129 (69%) were lost during the surveillance programme due to lack of compliance (97 cases) or death (32 cases). By comparison, among the 65 patients with hepatitis C-related cirrhosis, 18 were lost by lack of compliance (11 cases) or death (7 cases) (P<0.001). Moreover, sustained or relapsing alcohol abuse after inclusion in the surveillance programme were also related to the quality of the compliance. Seventeen hepatocarcinoma were discovered through the surveillance giving an annual incidence of 2% for the emergence of hepatocarcinoma. The comparison between screened (n=17) and incidental (n=40) hepatocarcinoma showed that screened HCC were more often asymptomatic (P<0.01), were more often a solitary nodule less than 5 cms (P<0.001) and underwent more often curative treatment (P=0.02). However, the survival between screened and incidental hepatocarcinoma was not different.
Screening for hepatocarcinoma in patients with alcoholic cirrhosis is a difficult task due to poor compliance and early death. According to our results, a surveillance every 6 months is sufficient to detect early lesions accessible to curative treatment by surgical resection or transcutaneous ablation.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>alpha-Fetoproteins - metabolism</subject><subject>Biopsy</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Cohort Studies</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Hepatitis C - complications</subject><subject>Humans</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Cirrhosis - virology</subject><subject>Liver Cirrhosis, Alcoholic - complications</subject><subject>Liver Cirrhosis, Alcoholic - diagnosis</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - mortality</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Mass Screening - psychology</subject><subject>Mass Screening - standards</subject><subject>Middle Aged</subject><subject>Patient Compliance - psychology</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Survival Analysis</subject><subject>Ultrasonography - methods</subject><subject>Ultrasonography - standards</subject><issn>0399-8320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j8tKw0AUhmeh2Fp9BTkvEJhLMpelFG9Q6KLdl8nJTHMkmQmTiPTtVdTVv_n4-P4rtubKucoqyVfsdp7fOefWGXHDVkLaWjlh1-xwwBJConSGmAv0YfJLRl-QUh49UAIPmPtcFvikpQekUvo80wyjpzRcIEfwww8xEEIudKZ0x66jH-Zw_7cbdnx-Om5fq93-5W37uKsmodxSYVdHNNa2Ta0xxha1jbZpdCM4N67TKsQgO9VKHRvpv9OdMNxFaTzXBlFt2MOvdvpox9CdpkKjL5fT_zn1BcsYS2Q</recordid><startdate>200305</startdate><enddate>200305</enddate><creator>Henrion, Jean</creator><creator>Libon, Ernest</creator><creator>De Maeght, Stéphane</creator><creator>Deltenre, Pierre</creator><creator>Schapira, Michaël</creator><creator>Ghilain, Jean-Michel</creator><creator>Maisin, Jean-Marc</creator><creator>Heller, Francis R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200305</creationdate><title>Screening for hepatocarcinoma in a cohort with cirrhosis mainly of alcoholic origin</title><author>Henrion, Jean ; Libon, Ernest ; De Maeght, Stéphane ; Deltenre, Pierre ; Schapira, Michaël ; Ghilain, Jean-Michel ; Maisin, Jean-Marc ; Heller, Francis R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-cd4fc788b546cffbc68f8556510079d63efe2d3b26f52a08991709f27a067cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>alpha-Fetoproteins - metabolism</topic><topic>Biopsy</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Cohort Studies</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Hepatitis C - complications</topic><topic>Humans</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver Cirrhosis - virology</topic><topic>Liver Cirrhosis, Alcoholic - complications</topic><topic>Liver Cirrhosis, Alcoholic - diagnosis</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver Neoplasms - mortality</topic><topic>Male</topic><topic>Mass Screening - methods</topic><topic>Mass Screening - psychology</topic><topic>Mass Screening - standards</topic><topic>Middle Aged</topic><topic>Patient Compliance - psychology</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Survival Analysis</topic><topic>Ultrasonography - methods</topic><topic>Ultrasonography - standards</topic><toplevel>online_resources</toplevel><creatorcontrib>Henrion, Jean</creatorcontrib><creatorcontrib>Libon, Ernest</creatorcontrib><creatorcontrib>De Maeght, Stéphane</creatorcontrib><creatorcontrib>Deltenre, Pierre</creatorcontrib><creatorcontrib>Schapira, Michaël</creatorcontrib><creatorcontrib>Ghilain, Jean-Michel</creatorcontrib><creatorcontrib>Maisin, Jean-Marc</creatorcontrib><creatorcontrib>Heller, Francis R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Gastroentérologie clinique et biologique</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henrion, Jean</au><au>Libon, Ernest</au><au>De Maeght, Stéphane</au><au>Deltenre, Pierre</au><au>Schapira, Michaël</au><au>Ghilain, Jean-Michel</au><au>Maisin, Jean-Marc</au><au>Heller, Francis R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Screening for hepatocarcinoma in a cohort with cirrhosis mainly of alcoholic origin</atitle><jtitle>Gastroentérologie clinique et biologique</jtitle><addtitle>Gastroenterol Clin Biol</addtitle><date>2003-05</date><risdate>2003</risdate><volume>27</volume><issue>5</issue><spage>534</spage><pages>534-</pages><issn>0399-8320</issn><abstract>To assess the feasibility and efficiency of the screening for hepatocarcinoma in a cohort of cirrhoseis mainly of alcoholic origin.
293 patients with cirrhosis, among them 186 (63.5%) from alcoholic origin, were included in a surveillance programme for hepatocarcinoma by carrying out liver ultrasonography and alpha-foetoprotein dosage every 6 months. Results were analyzed with a mean follow-up of 60 months. Seventeen hepatocarcinoma discovered through the surveillance programme ("screened HCC") were compared with 40 hepatocarcinoma discovered outside the surveillance programme during the same period ("incidental HCC").
The alcoholic origin of the cirrhosis was a predictive factor of poor compliance to the surveillance programme. Among the 186 patients with alcoholic cirrhosis, 129 (69%) were lost during the surveillance programme due to lack of compliance (97 cases) or death (32 cases). By comparison, among the 65 patients with hepatitis C-related cirrhosis, 18 were lost by lack of compliance (11 cases) or death (7 cases) (P<0.001). Moreover, sustained or relapsing alcohol abuse after inclusion in the surveillance programme were also related to the quality of the compliance. Seventeen hepatocarcinoma were discovered through the surveillance giving an annual incidence of 2% for the emergence of hepatocarcinoma. The comparison between screened (n=17) and incidental (n=40) hepatocarcinoma showed that screened HCC were more often asymptomatic (P<0.01), were more often a solitary nodule less than 5 cms (P<0.001) and underwent more often curative treatment (P=0.02). However, the survival between screened and incidental hepatocarcinoma was not different.
Screening for hepatocarcinoma in patients with alcoholic cirrhosis is a difficult task due to poor compliance and early death. According to our results, a surveillance every 6 months is sufficient to detect early lesions accessible to curative treatment by surgical resection or transcutaneous ablation.</abstract><cop>France</cop><pmid>12843918</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0399-8320 |
| ispartof | Gastroentérologie clinique et biologique, 2003-05, Vol.27 (5), p.534 |
| issn | 0399-8320 |
| language | fre |
| recordid | cdi_pubmed_primary_12843918 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over alpha-Fetoproteins - metabolism Biopsy Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - mortality Cohort Studies Feasibility Studies Female Hepatitis C - complications Humans Liver Cirrhosis - complications Liver Cirrhosis - diagnosis Liver Cirrhosis - virology Liver Cirrhosis, Alcoholic - complications Liver Cirrhosis, Alcoholic - diagnosis Liver Neoplasms - blood Liver Neoplasms - diagnosis Liver Neoplasms - etiology Liver Neoplasms - mortality Male Mass Screening - methods Mass Screening - psychology Mass Screening - standards Middle Aged Patient Compliance - psychology Prognosis Risk Factors Survival Analysis Ultrasonography - methods Ultrasonography - standards |
| title | Screening for hepatocarcinoma in a cohort with cirrhosis mainly of alcoholic origin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T17%3A10%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Screening%20for%20hepatocarcinoma%20in%20a%20cohort%20with%20cirrhosis%20mainly%20of%20alcoholic%20origin&rft.jtitle=Gastroent%C3%A9rologie%20clinique%20et%20biologique&rft.au=Henrion,%20Jean&rft.date=2003-05&rft.volume=27&rft.issue=5&rft.spage=534&rft.pages=534-&rft.issn=0399-8320&rft_id=info:doi/&rft_dat=%3Cpubmed%3E12843918%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/12843918&rfr_iscdi=true |