Expression of bone morphogenetic proteins in human prostatic adenocarcinoma and benign prostatic hyperplasia
There are important interactions between prostatic tumours and bone. This study was designed to examine whether prostatic tissue can express bone inductive factors, in particular, the Bone Morphogenetic Proteins (BMPs). The polymerase chain reaction (PCR) has been used to screen for the expression o...
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| Veröffentlicht in: | British journal of cancer 1992-12, Vol.66 (6), p.1159-1163 |
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| container_title | British journal of cancer |
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| creator | BENTLEY, H HAMDY, F. C HART, K. A SEID, J. M WILLIAMS, J. L JOHNSTONE, D RUSSELL, R. G. G |
| description | There are important interactions between prostatic tumours and bone. This study was designed to examine whether prostatic tissue can express bone inductive factors, in particular, the Bone Morphogenetic Proteins (BMPs). The polymerase chain reaction (PCR) has been used to screen for the expression of BMPs one to six in the prostatic tissue of patients with benign prostatic hyperplasia (BPH), non-metastatic prostatic adenocarcinoma and metastatic prostatic adenocarcinoma. BMPs were expressed in both benign and malignant prostate tissue and in the prostate tumour cell lines, PC3 and DU145. BMPs were also expressed in ocular melanoma tissue, a tissue which rarely metastasizes to bone. BMP-6 expression was detected in the prostate tissue of over 50% of patients with clinically defined metastatic prostate adenocarcinoma, but was not detected in non-metastatic or benign prostate samples or in ocular melanoma tissue. These findings suggest that the BMPs may play a role in the osteoinductive activity of prostate metastases and that the pattern of expression of BMPs may be important in the pathogenesis of osteoblastic metastases associated with prostate adenocarcinoma. |
| doi_str_mv | 10.1038/bjc.1992.427 |
| format | Article |
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C ; HART, K. A ; SEID, J. M ; WILLIAMS, J. L ; JOHNSTONE, D ; RUSSELL, R. G. G</creator><creatorcontrib>BENTLEY, H ; HAMDY, F. C ; HART, K. A ; SEID, J. M ; WILLIAMS, J. L ; JOHNSTONE, D ; RUSSELL, R. G. G</creatorcontrib><description>There are important interactions between prostatic tumours and bone. This study was designed to examine whether prostatic tissue can express bone inductive factors, in particular, the Bone Morphogenetic Proteins (BMPs). The polymerase chain reaction (PCR) has been used to screen for the expression of BMPs one to six in the prostatic tissue of patients with benign prostatic hyperplasia (BPH), non-metastatic prostatic adenocarcinoma and metastatic prostatic adenocarcinoma. BMPs were expressed in both benign and malignant prostate tissue and in the prostate tumour cell lines, PC3 and DU145. BMPs were also expressed in ocular melanoma tissue, a tissue which rarely metastasizes to bone. BMP-6 expression was detected in the prostate tissue of over 50% of patients with clinically defined metastatic prostate adenocarcinoma, but was not detected in non-metastatic or benign prostate samples or in ocular melanoma tissue. These findings suggest that the BMPs may play a role in the osteoinductive activity of prostate metastases and that the pattern of expression of BMPs may be important in the pathogenesis of osteoblastic metastases associated with prostate adenocarcinoma.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1992.427</identifier><identifier>PMID: 1280991</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Adenocarcinoma - chemistry ; Biological and medical sciences ; Bone Morphogenetic Protein 3 ; Bone Morphogenetic Proteins ; Humans ; Male ; Medical sciences ; Neoplasm Proteins - analysis ; Nephrology. Urinary tract diseases ; Polymerase Chain Reaction ; Prostatic Hyperplasia ; Prostatic Neoplasms - chemistry ; Proteins - analysis ; Tumor Cells, Cultured ; Tumors of the urinary system ; Urinary tract. 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C</creatorcontrib><creatorcontrib>HART, K. A</creatorcontrib><creatorcontrib>SEID, J. M</creatorcontrib><creatorcontrib>WILLIAMS, J. L</creatorcontrib><creatorcontrib>JOHNSTONE, D</creatorcontrib><creatorcontrib>RUSSELL, R. G. G</creatorcontrib><title>Expression of bone morphogenetic proteins in human prostatic adenocarcinoma and benign prostatic hyperplasia</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><description>There are important interactions between prostatic tumours and bone. This study was designed to examine whether prostatic tissue can express bone inductive factors, in particular, the Bone Morphogenetic Proteins (BMPs). The polymerase chain reaction (PCR) has been used to screen for the expression of BMPs one to six in the prostatic tissue of patients with benign prostatic hyperplasia (BPH), non-metastatic prostatic adenocarcinoma and metastatic prostatic adenocarcinoma. BMPs were expressed in both benign and malignant prostate tissue and in the prostate tumour cell lines, PC3 and DU145. BMPs were also expressed in ocular melanoma tissue, a tissue which rarely metastasizes to bone. BMP-6 expression was detected in the prostate tissue of over 50% of patients with clinically defined metastatic prostate adenocarcinoma, but was not detected in non-metastatic or benign prostate samples or in ocular melanoma tissue. These findings suggest that the BMPs may play a role in the osteoinductive activity of prostate metastases and that the pattern of expression of BMPs may be important in the pathogenesis of osteoblastic metastases associated with prostate adenocarcinoma.</description><subject>Adenocarcinoma - chemistry</subject><subject>Biological and medical sciences</subject><subject>Bone Morphogenetic Protein 3</subject><subject>Bone Morphogenetic Proteins</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasm Proteins - analysis</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Polymerase Chain Reaction</subject><subject>Prostatic Hyperplasia</subject><subject>Prostatic Neoplasms - chemistry</subject><subject>Proteins - analysis</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. 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Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BENTLEY, H</creatorcontrib><creatorcontrib>HAMDY, F. C</creatorcontrib><creatorcontrib>HART, K. A</creatorcontrib><creatorcontrib>SEID, J. M</creatorcontrib><creatorcontrib>WILLIAMS, J. L</creatorcontrib><creatorcontrib>JOHNSTONE, D</creatorcontrib><creatorcontrib>RUSSELL, R. G. G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BENTLEY, H</au><au>HAMDY, F. C</au><au>HART, K. A</au><au>SEID, J. M</au><au>WILLIAMS, J. L</au><au>JOHNSTONE, D</au><au>RUSSELL, R. G. G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of bone morphogenetic proteins in human prostatic adenocarcinoma and benign prostatic hyperplasia</atitle><jtitle>British journal of cancer</jtitle><addtitle>Br J Cancer</addtitle><date>1992-12-01</date><risdate>1992</risdate><volume>66</volume><issue>6</issue><spage>1159</spage><epage>1163</epage><pages>1159-1163</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>There are important interactions between prostatic tumours and bone. This study was designed to examine whether prostatic tissue can express bone inductive factors, in particular, the Bone Morphogenetic Proteins (BMPs). The polymerase chain reaction (PCR) has been used to screen for the expression of BMPs one to six in the prostatic tissue of patients with benign prostatic hyperplasia (BPH), non-metastatic prostatic adenocarcinoma and metastatic prostatic adenocarcinoma. BMPs were expressed in both benign and malignant prostate tissue and in the prostate tumour cell lines, PC3 and DU145. BMPs were also expressed in ocular melanoma tissue, a tissue which rarely metastasizes to bone. BMP-6 expression was detected in the prostate tissue of over 50% of patients with clinically defined metastatic prostate adenocarcinoma, but was not detected in non-metastatic or benign prostate samples or in ocular melanoma tissue. These findings suggest that the BMPs may play a role in the osteoinductive activity of prostate metastases and that the pattern of expression of BMPs may be important in the pathogenesis of osteoblastic metastases associated with prostate adenocarcinoma.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>1280991</pmid><doi>10.1038/bjc.1992.427</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - chemistry Biological and medical sciences Bone Morphogenetic Protein 3 Bone Morphogenetic Proteins Humans Male Medical sciences Neoplasm Proteins - analysis Nephrology. Urinary tract diseases Polymerase Chain Reaction Prostatic Hyperplasia Prostatic Neoplasms - chemistry Proteins - analysis Tumor Cells, Cultured Tumors of the urinary system Urinary tract. Prostate gland |
| title | Expression of bone morphogenetic proteins in human prostatic adenocarcinoma and benign prostatic hyperplasia |
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