The transcription factor CCAAT-binding factor CBF/NF-Y regulates the proximal promoter activity in the human alpha 1(XI) collagen gene (COL11A1)

We have characterized the proximal promoter region of the human COL11A1 gene. Transient transfection assays indicate that the segment from -199 to +1 is necessary for the activation of basal transcription. Electrophoretic mobility shift assays (EMSAs) demonstrated that the ATTGG sequence, within the...

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Veröffentlicht in:	The Journal of biological chemistry 2003-08, Vol.278 (35), p.32763
Hauptverfasser:	Matsuo, Noritaka, Yu-Hua, Wang, Sumiyoshi, Hideaki, Sakata-Takatani, Keiko, Nagato, Hitoshi, Sakai, Kumiko, Sakurai, Mami, Yoshioka, Hidekatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding Sites CCAAT-Binding Factor - physiology Cell Nucleus - metabolism Chromatin - metabolism Collagen - genetics Collagen - metabolism Collagen Type XI - genetics Collagen Type XI - metabolism DNA - metabolism Gene Deletion Gene Expression Regulation Genes, Dominant Humans Luciferases - metabolism Models, Genetic Molecular Sequence Data Plasmids - metabolism Precipitin Tests Promoter Regions, Genetic Protein Binding Recombinant Fusion Proteins - metabolism Transcription Factors - physiology Transcription, Genetic Transfection Tumor Cells, Cultured
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