Human Monoclonal Fab Fragments Derived from a Combinatorial Library Bind to Respiratory Syncytial Virus F Glycoprotein and Neutralize Infectivity

Respiratory syncytial virus (RSV) is the most important cause, throughout the world, of severe viral lower respiratory tract illness in young children. Antibodies are known to mediate resistance to RSV infection and illness. We have isolated a number of human monoclonal Fab fragments to RSV F glycop...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-11, Vol.89 (21), p.10164-10168
Hauptverfasser:	Barbas, Carlos F., Crowe, James E., Cababa, Doug, Jones, Terri M., Zebedee, Suzanne L., Murphy, Brian R., Chanock, Robert M., Burton, Dennis R.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Antibodies Antibodies, Monoclonal - genetics Antibodies, Monoclonal - metabolism Antigen-antibody reactions, antigen-antibody complexes, antibody-complement and others. Study of affinity. Antigen presentation Antigens Antigens, Viral - immunology Bacteriophages Base Sequence Binding Sites, Antibody Binding, Competitive Biological and medical sciences Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Library Glycoproteins HIV 1 HIV Seropositivity - immunology HN Protein Human respiratory syncytial virus Humans Immunity (Disease) Immunoglobulin Fab Fragments - genetics Immunoglobulin Fab Fragments - metabolism Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - metabolism Libraries Lymphocytes - immunology Medical research Molecular immunology Molecular Sequence Data Monoclonal antibodies Neutralization Tests Oligodeoxyribonucleotides Proteins Respiratory diseases respiratory syncytial virus Respiratory Syncytial Viruses - immunology Respiratory therapy RNA - genetics RNA - isolation & purification Viral Envelope Proteins Viral Fusion Proteins - immunology Viral Proteins Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!