Validation of the Hexose Transporter of Plasmodium falciparum as a Novel Drug Target

Chemotherapy of malaria parasites is limited by established drug resistance and lack of novel targets. Intraerythrocytic stages of Plasmodium falciparum are wholly dependent on host glucose for energy. Glucose uptake is mediated by a parasite-encoded facilitative hexose transporter (PfHT). We report...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-06, Vol.100 (13), p.7476-7479
Hauptverfasser:	Joët, Thierry, Eckstein-Ludwig, Ursula, Morin, Christophe, Krishna, Sanjeev
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antimalarials Biological Sciences Cloning, Molecular Dose-Response Relationship, Drug Drug therapy Erythrocytes Facilitative glucose transport proteins Freshwater Fructose - pharmacology Glucose Glucose - pharmacology Hexoses Inhibitory Concentration 50 Kinetics Malaria Malaria - therapy Mice Monosaccharide Transport Proteins - chemistry Monosaccharide Transport Proteins - genetics Monosaccharide Transport Proteins - metabolism Oocytes Parasites Parasitism Plasmodium berghei - metabolism Plasmodium falciparum - metabolism Plasmodium vivax - genetics Plasmodium vivax - metabolism Species Specificity Xenopus laevis
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