Activation of estrogen receptor alpha and ERbeta by 4-methylbenzylidene-camphor in human and rat cells: comparison with phyto- and xenoestrogens

4-Methylbenzylidene-camphor (4-MBC) is an organic sunscreen that protects against UV radiation and may therefore help in the prevention of skin cancer. Recent results on the estrogenicity of 4-MBC have raised concerns about a potential of 4-MBC to act as an endocrine disruptor. Here, we investigated...

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Veröffentlicht in:	Toxicology letters 2003-04, Vol.142 (1-2), p.89
Hauptverfasser:	Mueller, Stefan O, Kling, Margret, Arifin Firzani, Poppy, Mecky, Astrid, Duranti, Eric, Shields-Botella, Jacqueline, Delansorne, Remi, Broschard, Thomas, Kramer, Peter-Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Animals Anticarcinogenic Agents - pharmacology Benzylidene Compounds - pharmacology Camphor - analogs & derivatives Camphor - pharmacology Diethylstilbestrol - pharmacology Endometrium - cytology Endometrium - drug effects Endometrium - metabolism Enzyme Activation - drug effects Estradiol - pharmacology Estrogen Antagonists - pharmacology Estrogen Receptor alpha Estrogen Receptor beta Estrogens - pharmacology Estrogens, Non-Steroidal - pharmacology Female Hepatocytes - drug effects Hepatocytes - metabolism Humans Isoflavones Male Phytoestrogens Plant Preparations Rats Rats, Wistar Receptors, Estrogen - agonists Receptors, Estrogen - antagonists & inhibitors Receptors, Estrogen - biosynthesis Receptors, Estrogen - metabolism Sunscreening Agents - pharmacology
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