A case of cutaneous leukocytoclastic vasculitis associated with gabapentin
Gabapentin was approved for use in the USA in 1994 as an add-on drug in adults who have partial seizures either alone or with secondary generalised seizures. Its use has been expanded to include treatment for other conditions such as neuropathic pain and paraesthesiae. Gabapentin was prescribed for...
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| Veröffentlicht in: | Singapore medical journal 2003, Vol.44 (1), p.42-44 |
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| creator | POON, D. Y. H LAW, N. M |
| description | Gabapentin was approved for use in the USA in 1994 as an add-on drug in adults who have partial seizures either alone or with secondary generalised seizures. Its use has been expanded to include treatment for other conditions such as neuropathic pain and paraesthesiae. Gabapentin was prescribed for our patient who had persistent left-sided hemi-paraesthesiae consequential of a previous thalamic infarct. One week after commencement of gabapentin, she developed an adverse reaction in the form of a purpuric rash over bilateral lower limbs. Skin biopsy revealed histological features of cutaneous leukocytoclastic vasculitis. This rash completely resolved with withdrawal of gabapentin and steroidal treatment. This cutaneous adverse reaction to gabapentin has not been reported in the medical literature. |
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Y. H ; LAW, N. M</creator><creatorcontrib>POON, D. Y. H ; LAW, N. M</creatorcontrib><description>Gabapentin was approved for use in the USA in 1994 as an add-on drug in adults who have partial seizures either alone or with secondary generalised seizures. Its use has been expanded to include treatment for other conditions such as neuropathic pain and paraesthesiae. Gabapentin was prescribed for our patient who had persistent left-sided hemi-paraesthesiae consequential of a previous thalamic infarct. One week after commencement of gabapentin, she developed an adverse reaction in the form of a purpuric rash over bilateral lower limbs. Skin biopsy revealed histological features of cutaneous leukocytoclastic vasculitis. This rash completely resolved with withdrawal of gabapentin and steroidal treatment. 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M</creatorcontrib><title>A case of cutaneous leukocytoclastic vasculitis associated with gabapentin</title><title>Singapore medical journal</title><addtitle>Singapore Med J</addtitle><description>Gabapentin was approved for use in the USA in 1994 as an add-on drug in adults who have partial seizures either alone or with secondary generalised seizures. Its use has been expanded to include treatment for other conditions such as neuropathic pain and paraesthesiae. Gabapentin was prescribed for our patient who had persistent left-sided hemi-paraesthesiae consequential of a previous thalamic infarct. One week after commencement of gabapentin, she developed an adverse reaction in the form of a purpuric rash over bilateral lower limbs. Skin biopsy revealed histological features of cutaneous leukocytoclastic vasculitis. This rash completely resolved with withdrawal of gabapentin and steroidal treatment. This cutaneous adverse reaction to gabapentin has not been reported in the medical literature.</description><subject>Acetates - adverse effects</subject><subject>Aged</subject><subject>Amines</subject><subject>Anticonvulsants - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Cyclohexanecarboxylic Acids</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Foot</subject><subject>gamma-Aminobutyric Acid</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of cutaneous leukocytoclastic vasculitis associated with gabapentin</atitle><jtitle>Singapore medical journal</jtitle><addtitle>Singapore Med J</addtitle><date>2003</date><risdate>2003</risdate><volume>44</volume><issue>1</issue><spage>42</spage><epage>44</epage><pages>42-44</pages><issn>0037-5675</issn><coden>SIMJA3</coden><abstract>Gabapentin was approved for use in the USA in 1994 as an add-on drug in adults who have partial seizures either alone or with secondary generalised seizures. Its use has been expanded to include treatment for other conditions such as neuropathic pain and paraesthesiae. Gabapentin was prescribed for our patient who had persistent left-sided hemi-paraesthesiae consequential of a previous thalamic infarct. One week after commencement of gabapentin, she developed an adverse reaction in the form of a purpuric rash over bilateral lower limbs. Skin biopsy revealed histological features of cutaneous leukocytoclastic vasculitis. This rash completely resolved with withdrawal of gabapentin and steroidal treatment. This cutaneous adverse reaction to gabapentin has not been reported in the medical literature.</abstract><cop>Singapore</cop><pub>Singapore Medical Association</pub><pmid>12762564</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Singapore medical journal, 2003, Vol.44 (1), p.42-44 |
| issn | 0037-5675 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acetates - adverse effects Aged Amines Anticonvulsants - adverse effects Biological and medical sciences Cyclohexanecarboxylic Acids Drug toxicity and drugs side effects treatment Female Foot gamma-Aminobutyric Acid Humans Medical sciences Pharmacology. Drug treatments Toxicity: cardiovascular system Tropical medicine Vasculitis, Leukocytoclastic, Cutaneous - chemically induced |
| title | A case of cutaneous leukocytoclastic vasculitis associated with gabapentin |
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