The Effects of Posteroventral Pallidotomy on Balance Function in Patients with Parkinson’s Disease
Parkinson’s disease is a chronic, progressive neurodegenerative disorder resulting from dopaminergic cell loss in the pars compacta of the substantia nigra. Conventional treatment of Parkinson’s disease consists of pharmacological replacement of dopamine. A treatment alternative, posteroventral pall...
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| Veröffentlicht in: | Stereotactic and functional neurosurgery 2002-01, Vol.79 (2), p.75-87 |
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| container_title | Stereotactic and functional neurosurgery |
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| creator | Westerberg, B.D. Roberson, J.B. Stach, B.A. Silverberg, G.D. Heit, G. |
| description | Parkinson’s disease is a chronic, progressive neurodegenerative disorder resulting from dopaminergic cell loss in the pars compacta of the substantia nigra. Conventional treatment of Parkinson’s disease consists of pharmacological replacement of dopamine. A treatment alternative, posteroventral pallidotomy (PVP), has been used for medically intractable stages of the disease. The purpose of this study was to evaluate the effects of PVP on balance function, as measured by dynamic posturography, in patients with medically intractable Parkinson’s disease. Five subjects were studied within 2 days prior to and within 6 months following PVP. Pretreatment abnormalities were found in vestibular, visual, and somatosensory processing in balance function. Posteroventral pallidotomy resulted in improvement in vestibular compensation of posture in some patients, which may be at least partially due to an improvement in latencies to respond to changes in stance. Dynamic posturography is an effective tool in the evaluation of balance and posture in patients with advanced Parkinson’s disease. |
| doi_str_mv | 10.1159/000070103 |
| format | Article |
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Conventional treatment of Parkinson’s disease consists of pharmacological replacement of dopamine. A treatment alternative, posteroventral pallidotomy (PVP), has been used for medically intractable stages of the disease. The purpose of this study was to evaluate the effects of PVP on balance function, as measured by dynamic posturography, in patients with medically intractable Parkinson’s disease. Five subjects were studied within 2 days prior to and within 6 months following PVP. Pretreatment abnormalities were found in vestibular, visual, and somatosensory processing in balance function. Posteroventral pallidotomy resulted in improvement in vestibular compensation of posture in some patients, which may be at least partially due to an improvement in latencies to respond to changes in stance. Dynamic posturography is an effective tool in the evaluation of balance and posture in patients with advanced Parkinson’s disease.</description><identifier>ISSN: 1011-6125</identifier><identifier>EISSN: 1423-0372</identifier><identifier>DOI: 10.1159/000070103</identifier><identifier>PMID: 12743429</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Aged ; Biological and medical sciences ; Female ; Globus Pallidus - surgery ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurosurgery ; Original Paper ; Parkinson Disease - physiopathology ; Parkinson Disease - surgery ; Postural Balance ; Posture ; Reaction Time ; Skull, brain, vascular surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><ispartof>Stereotactic and functional neurosurgery, 2002-01, Vol.79 (2), p.75-87</ispartof><rights>2002 S. Karger AG, Basel</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2002 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-4993763b88fa5ffa5be75608eeccabdc2b62ed57a50611824aa9e2b2215702783</citedby><cites>FETCH-LOGICAL-c331t-4993763b88fa5ffa5be75608eeccabdc2b62ed57a50611824aa9e2b2215702783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14786843$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12743429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Westerberg, B.D.</creatorcontrib><creatorcontrib>Roberson, J.B.</creatorcontrib><creatorcontrib>Stach, B.A.</creatorcontrib><creatorcontrib>Silverberg, G.D.</creatorcontrib><creatorcontrib>Heit, G.</creatorcontrib><title>The Effects of Posteroventral Pallidotomy on Balance Function in Patients with Parkinson’s Disease</title><title>Stereotactic and functional neurosurgery</title><addtitle>Stereotact Funct Neurosurg</addtitle><description>Parkinson’s disease is a chronic, progressive neurodegenerative disorder resulting from dopaminergic cell loss in the pars compacta of the substantia nigra. Conventional treatment of Parkinson’s disease consists of pharmacological replacement of dopamine. A treatment alternative, posteroventral pallidotomy (PVP), has been used for medically intractable stages of the disease. The purpose of this study was to evaluate the effects of PVP on balance function, as measured by dynamic posturography, in patients with medically intractable Parkinson’s disease. Five subjects were studied within 2 days prior to and within 6 months following PVP. Pretreatment abnormalities were found in vestibular, visual, and somatosensory processing in balance function. Posteroventral pallidotomy resulted in improvement in vestibular compensation of posture in some patients, which may be at least partially due to an improvement in latencies to respond to changes in stance. Dynamic posturography is an effective tool in the evaluation of balance and posture in patients with advanced Parkinson’s disease.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Globus Pallidus - surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurosurgery</subject><subject>Original Paper</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - surgery</subject><subject>Postural Balance</subject><subject>Posture</subject><subject>Reaction Time</subject><subject>Skull, brain, vascular surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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Transplantations, organ and tissue grafts. Graft diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Westerberg, B.D.</creatorcontrib><creatorcontrib>Roberson, J.B.</creatorcontrib><creatorcontrib>Stach, B.A.</creatorcontrib><creatorcontrib>Silverberg, G.D.</creatorcontrib><creatorcontrib>Heit, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stereotactic and functional neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Westerberg, B.D.</au><au>Roberson, J.B.</au><au>Stach, B.A.</au><au>Silverberg, G.D.</au><au>Heit, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Posteroventral Pallidotomy on Balance Function in Patients with Parkinson’s Disease</atitle><jtitle>Stereotactic and functional neurosurgery</jtitle><addtitle>Stereotact Funct Neurosurg</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>79</volume><issue>2</issue><spage>75</spage><epage>87</epage><pages>75-87</pages><issn>1011-6125</issn><eissn>1423-0372</eissn><abstract>Parkinson’s disease is a chronic, progressive neurodegenerative disorder resulting from dopaminergic cell loss in the pars compacta of the substantia nigra. Conventional treatment of Parkinson’s disease consists of pharmacological replacement of dopamine. A treatment alternative, posteroventral pallidotomy (PVP), has been used for medically intractable stages of the disease. The purpose of this study was to evaluate the effects of PVP on balance function, as measured by dynamic posturography, in patients with medically intractable Parkinson’s disease. Five subjects were studied within 2 days prior to and within 6 months following PVP. Pretreatment abnormalities were found in vestibular, visual, and somatosensory processing in balance function. Posteroventral pallidotomy resulted in improvement in vestibular compensation of posture in some patients, which may be at least partially due to an improvement in latencies to respond to changes in stance. Dynamic posturography is an effective tool in the evaluation of balance and posture in patients with advanced Parkinson’s disease.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>12743429</pmid><doi>10.1159/000070103</doi><tpages>13</tpages></addata></record> |
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| source | MEDLINE; Karger Journals Complete |
| subjects | Aged Biological and medical sciences Female Globus Pallidus - surgery Humans Male Medical sciences Middle Aged Neurosurgery Original Paper Parkinson Disease - physiopathology Parkinson Disease - surgery Postural Balance Posture Reaction Time Skull, brain, vascular surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases |
| title | The Effects of Posteroventral Pallidotomy on Balance Function in Patients with Parkinson’s Disease |
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