Thrombospondin-bound integrin-associated protein (CD47) physically and functionally modifies integrin alphaIIbbeta3 by its extracellular domain

Integrin-associated protein (IAP/CD47) is a receptor for the C-terminal cell binding domain of thrombospondin (TS). A peptide from the C-terminal cell binding domain, KRFYVVMWKK (4N1K) binds to IAP and stimulates the integrin-dependent cell functions, including platelet aggregation. We investigated...

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Veröffentlicht in:	The Journal of biological chemistry 2003-07, Vol.278 (29), p.26655
Hauptverfasser:	Fujimoto, Tetsuro-Takahiro, Katsutani, Shinya, Shimomura, Takeshi, Fujimura, Kingo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens, CD - chemistry Antigens, CD - genetics Antigens, CD - metabolism Binding Sites Blood Platelets - metabolism Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism CD47 Antigen CHO Cells Cricetinae Humans In Vitro Techniques Mice Mutagenesis, Site-Directed Oligopeptides - chemistry Oligopeptides - pharmacology Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Platelet Aggregation - drug effects Platelet Glycoprotein GPIIb-IIIa Complex - chemistry Platelet Glycoprotein GPIIb-IIIa Complex - genetics Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Protein Binding Protein Structure, Tertiary Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Signal Transduction Thrombospondins - chemistry Thrombospondins - genetics Thrombospondins - metabolism Transfection
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