Amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sAPP- and Abeta-mediated neurotoxicity

Increasing evidence strongly supports the role of glial immunity in the pathogenesis of Alzheimer's disease (AD). To investigate such events we have developed cell systems mimicking the interactions between beta-amyloid precursor protein (APP)-expressing neurons and brain mononuclear phagocytes...

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Veröffentlicht in:	Journal of neurochemistry 2003-05, Vol.85 (4), p.925
Hauptverfasser:	Ikezu, Tsuneya, Luo, Xiaoguang, Weber, Gregory A, Zhao, Jianxing, McCabe, Laura, Buescher, James L, Ghorpade, Anuja, Zheng, Jialin, Xiong, Huangui
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System y Amyloid beta-Peptides - biosynthesis Amyloid beta-Peptides - toxicity Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Amyloid beta-Protein Precursor - toxicity Animals Carrier Proteins - antagonists & inhibitors Carrier Proteins - metabolism Cells, Cultured Coculture Techniques Free Radical Scavengers - pharmacology Glutamic Acid - metabolism Humans L-Lactate Dehydrogenase - metabolism Macrophage Activation - drug effects Macrophages - cytology Macrophages - drug effects Macrophages - physiology Microglia - cytology Microglia - drug effects Microglia - physiology Monocytes - cytology Monocytes - drug effects Monocytes - physiology Mutation Neurons - cytology Neurons - drug effects Neurons - metabolism Oocytes - metabolism Patch-Clamp Techniques PC12 Cells Phagocytes - cytology Phagocytes - drug effects Phagocytes - physiology Protein Processing, Post-Translational Rats Rats, Sprague-Dawley Signal Transduction - drug effects Signal Transduction - physiology Transfection Xenopus laevis
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