A Comparison of Two Transfusion Regimens in the Perioperative Management of Children with Sickle Cell Disease Undergoing Adenotonsillectomy
Adenotonsillar hypertrophy and chronic tonsillitis are common findings in patients with sickle cell disease (SCD). Various preoperative transfusion regimens have been suggested to reduce the population of sickle erythrocytes and correct the anemia, ranging from conservative (correcting the anemia) t...
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| Veröffentlicht in: | Pediatric hematology and oncology 2003, Vol.20 (1), p.7-13 |
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| creator | Wali, Yasser A. Okbi, Hesham Al Abri, Rashed Al |
| description | Adenotonsillar hypertrophy and chronic tonsillitis are common findings in patients with sickle cell disease (SCD). Various preoperative transfusion regimens have been suggested to reduce the population of sickle erythrocytes and correct the anemia, ranging from conservative (correcting the anemia) to aggressive (lowering the level of HbS to less than 30%). A total of 39 patients with SCD were included in the study. They were divided into 2 groups. Fourteen patients in group 1 were assigned aggressive exchange transfusion and 25 patients in group 2 were assigned a conservative (simple) transfusion. The 2 groups were compared for possible operative and postoperative complications. Thirty percent of patients in both groups had postoperative complications. They ranged from mild local infection to acute chest syndrome. Simple transfusion was not associated with higher incidence of complications and resulted in only one-third as many transfusion requirements. |
| doi_str_mv | 10.1080/0880010390158487 |
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Various preoperative transfusion regimens have been suggested to reduce the population of sickle erythrocytes and correct the anemia, ranging from conservative (correcting the anemia) to aggressive (lowering the level of HbS to less than 30%). A total of 39 patients with SCD were included in the study. They were divided into 2 groups. Fourteen patients in group 1 were assigned aggressive exchange transfusion and 25 patients in group 2 were assigned a conservative (simple) transfusion. The 2 groups were compared for possible operative and postoperative complications. Thirty percent of patients in both groups had postoperative complications. They ranged from mild local infection to acute chest syndrome. Simple transfusion was not associated with higher incidence of complications and resulted in only one-third as many transfusion requirements.</description><identifier>ISSN: 0888-0018</identifier><identifier>EISSN: 1521-0669</identifier><identifier>DOI: 10.1080/0880010390158487</identifier><identifier>PMID: 12687748</identifier><identifier>CODEN: PHONEN</identifier><language>eng</language><publisher>Philadelphia, PA: Informa UK Ltd</publisher><subject>Adenoidectomy - adverse effects ; Adenoidectomy - methods ; Adenotonsillectomy ; Adolescent ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - therapy ; Anemias. Hemoglobinopathies ; Biological and medical sciences ; Blood Transfusion - methods ; Child ; Child, Preschool ; Diseases of red blood cells ; Female ; Hematologic and hematopoietic diseases ; Humans ; Intraoperative Complications - prevention & control ; Male ; Medical sciences ; Perioperative Care - methods ; Postoperative Complications - prevention & control ; Sickle ; Tonsillectomy - adverse effects ; Tonsillectomy - methods ; Transfusion ; Transfusion Reaction</subject><ispartof>Pediatric hematology and oncology, 2003, Vol.20 (1), p.7-13</ispartof><rights>2003 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2003</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-839e695bc950f640da2e1e50090ba573a11d94a32c346e3de1c9e4f2c0c1a9213</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/0880010390158487$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/0880010390158487$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4009,27902,27903,27904,59623,59729,60412,60518,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14498693$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12687748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wali, Yasser A.</creatorcontrib><creatorcontrib>Okbi, Hesham Al</creatorcontrib><creatorcontrib>Abri, Rashed Al</creatorcontrib><title>A Comparison of Two Transfusion Regimens in the Perioperative Management of Children with Sickle Cell Disease Undergoing Adenotonsillectomy</title><title>Pediatric hematology and oncology</title><addtitle>Pediatr Hematol Oncol</addtitle><description>Adenotonsillar hypertrophy and chronic tonsillitis are common findings in patients with sickle cell disease (SCD). Various preoperative transfusion regimens have been suggested to reduce the population of sickle erythrocytes and correct the anemia, ranging from conservative (correcting the anemia) to aggressive (lowering the level of HbS to less than 30%). A total of 39 patients with SCD were included in the study. They were divided into 2 groups. Fourteen patients in group 1 were assigned aggressive exchange transfusion and 25 patients in group 2 were assigned a conservative (simple) transfusion. The 2 groups were compared for possible operative and postoperative complications. Thirty percent of patients in both groups had postoperative complications. They ranged from mild local infection to acute chest syndrome. Simple transfusion was not associated with higher incidence of complications and resulted in only one-third as many transfusion requirements.</description><subject>Adenoidectomy - adverse effects</subject><subject>Adenoidectomy - methods</subject><subject>Adenotonsillectomy</subject><subject>Adolescent</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Anemia, Sickle Cell - therapy</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>Blood Transfusion - methods</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Intraoperative Complications - prevention & control</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Perioperative Care - methods</subject><subject>Postoperative Complications - prevention & control</subject><subject>Sickle</subject><subject>Tonsillectomy - adverse effects</subject><subject>Tonsillectomy - methods</subject><subject>Transfusion</subject><subject>Transfusion Reaction</subject><issn>0888-0018</issn><issn>1521-0669</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1vEzEQhlcIRNPCnRPyBW4LY3s_bDhFS_mQikCQnleOdzZx8drB9hLlN_CncZWgCiQ4WfI8z2jmnaJ4QuEFBQEvQQgAClwCrUUl2nvFgtaMltA08n6xyGVRZkCcFecx3gAA4y17WJxR1oi2rcSi-LkknZ92KpjoHfEjWe09WQXl4jhHk7--4MZM6CIxjqQtks8YjN9hUMn8QPJRObXBXE-3brc1dgjoyN6kLflq9DeLpENryRsTUUUk127AsPHGbchyQOeTd9FYizr56fCoeDAqG_Hx6b0ort9errr35dWndx-65VWpKyZSKbjERtZrLWsYmwoGxZBiDSBhreqWK0oHWSnONK8a5ANSLbEamQZNlWSUXxTPj313wX-fMaZ-MlHnMZVDP8e-5VTUTLIMwhHUwccYcOx3wUwqHHoK_e0B-r8PkJWnp97zesLhTjglnoFnJ0BFreyYo9Ym3nFVJUUjeeZeHznjRh8mtffBDn1SB-vDb4n_Z4xXf9hbVDZttQrY3_g5uBzvv3f4Ba5ltCI</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>Wali, Yasser A.</creator><creator>Okbi, Hesham Al</creator><creator>Abri, Rashed Al</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2003</creationdate><title>A Comparison of Two Transfusion Regimens in the Perioperative Management of Children with Sickle Cell Disease Undergoing Adenotonsillectomy</title><author>Wali, Yasser A. ; Okbi, Hesham Al ; Abri, Rashed Al</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-839e695bc950f640da2e1e50090ba573a11d94a32c346e3de1c9e4f2c0c1a9213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adenoidectomy - adverse effects</topic><topic>Adenoidectomy - methods</topic><topic>Adenotonsillectomy</topic><topic>Adolescent</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Anemia, Sickle Cell - therapy</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>Blood Transfusion - methods</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diseases of red blood cells</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Intraoperative Complications - prevention & control</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Perioperative Care - methods</topic><topic>Postoperative Complications - prevention & control</topic><topic>Sickle</topic><topic>Tonsillectomy - adverse effects</topic><topic>Tonsillectomy - methods</topic><topic>Transfusion</topic><topic>Transfusion Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wali, Yasser A.</creatorcontrib><creatorcontrib>Okbi, Hesham Al</creatorcontrib><creatorcontrib>Abri, Rashed Al</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric hematology and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wali, Yasser A.</au><au>Okbi, Hesham Al</au><au>Abri, Rashed Al</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Comparison of Two Transfusion Regimens in the Perioperative Management of Children with Sickle Cell Disease Undergoing Adenotonsillectomy</atitle><jtitle>Pediatric hematology and oncology</jtitle><addtitle>Pediatr Hematol Oncol</addtitle><date>2003</date><risdate>2003</risdate><volume>20</volume><issue>1</issue><spage>7</spage><epage>13</epage><pages>7-13</pages><issn>0888-0018</issn><eissn>1521-0669</eissn><coden>PHONEN</coden><abstract>Adenotonsillar hypertrophy and chronic tonsillitis are common findings in patients with sickle cell disease (SCD). Various preoperative transfusion regimens have been suggested to reduce the population of sickle erythrocytes and correct the anemia, ranging from conservative (correcting the anemia) to aggressive (lowering the level of HbS to less than 30%). A total of 39 patients with SCD were included in the study. They were divided into 2 groups. Fourteen patients in group 1 were assigned aggressive exchange transfusion and 25 patients in group 2 were assigned a conservative (simple) transfusion. The 2 groups were compared for possible operative and postoperative complications. Thirty percent of patients in both groups had postoperative complications. They ranged from mild local infection to acute chest syndrome. Simple transfusion was not associated with higher incidence of complications and resulted in only one-third as many transfusion requirements.</abstract><cop>Philadelphia, PA</cop><pub>Informa UK Ltd</pub><pmid>12687748</pmid><doi>10.1080/0880010390158487</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Pediatric hematology and oncology, 2003, Vol.20 (1), p.7-13 |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adenoidectomy - adverse effects Adenoidectomy - methods Adenotonsillectomy Adolescent Anemia, Sickle Cell - complications Anemia, Sickle Cell - therapy Anemias. Hemoglobinopathies Biological and medical sciences Blood Transfusion - methods Child Child, Preschool Diseases of red blood cells Female Hematologic and hematopoietic diseases Humans Intraoperative Complications - prevention & control Male Medical sciences Perioperative Care - methods Postoperative Complications - prevention & control Sickle Tonsillectomy - adverse effects Tonsillectomy - methods Transfusion Transfusion Reaction |
| title | A Comparison of Two Transfusion Regimens in the Perioperative Management of Children with Sickle Cell Disease Undergoing Adenotonsillectomy |
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