The Hydration Structure of Guanidinium and Thiocyanate Ions: Implications for Protein Stability in Aqueous Solution

Neutron diffraction experiments were carried out on aqueous solutions containing either guanidinium or thiocyanate ions. The first-order difference method of neutron diffraction and isotopic substitution was applied, and the hydration structures of two of nature's strongest denaturant ions were...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-04, Vol.100 (8), p.4557-4561
Hauptverfasser:	Mason, P. E., Neilson, G. W., Dempsey, C. E., Barnes, A. C., Cruickshank, J. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anions Atoms Biological Sciences Biophysical Phenomena Biophysics Cations Coordination numbers Correlations Drug Stability Guanidine - chemistry Hydrogen Hydrogen Bonding Hydrogen bonds Ions Molecules Nitrogen Protein Denaturation Proteins Proteins - chemistry Solutions Thiocyanates - chemistry Water - chemistry
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