Targeting aurora2 kinase in oncogenesis: a structural bioinformatics approach to target validation and rational drug design

The aurora kinases are a novel oncogenic family of mitotic serine/threonine kinases (S/T kinases) that are overexpressed in a number of solid tumors, including pancreas and colorectal cancer. A PSI-BLAST search [National Center for Biotechnology Information (NCBI)] with the sequence of the S/T kinas...

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Veröffentlicht in:	Molecular cancer therapeutics 2003-03, Vol.2 (3), p.283
Hauptverfasser:	Vankayalapati, Hariprasad, Bearss, David J, Saldanha, José W, Muñoz, Rubén M, Rojanala, Sangeeta, Von Hoff, Daniel D, Mahadevan, Daruka
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antineoplastic Agents - pharmacology Aurora Kinase A Aurora Kinase B Aurora Kinases Caenorhabditis elegans - enzymology Caenorhabditis elegans Proteins Calmodulin-Binding Proteins - chemistry Cattle Computational Biology Cyclic AMP-Dependent Protein Kinases - chemistry Drug Design Humans Mice Models, Molecular Molecular Sequence Data Molecular Structure Muscle Proteins - chemistry Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - enzymology Protein Conformation Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - chemistry Sequence Homology, Amino Acid Staurosporine - chemistry Staurosporine - metabolism Structure-Activity Relationship
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