Nalpha-methylhistamine safety and efficacy in migraine prophylaxis: phase I and phase II studies

To study the therapeutic potential of the subcutaneous administration of Nalpha-methylhistamine in migraine prophylaxis. The histamine catabolite, Nalpha-methylhistamine, possesses a selective affinity for H3 receptors. We consequently considered it viable to conduct a clinical pharmacological study...

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Veröffentlicht in:	Headache 2003-04, Vol.43 (4), p.389
Hauptverfasser:	Millán-Guerrero, Rebeca O, Pineda-Lucatero, Alicia G, Hernández-Benjamín, Trujillo, Tene, Carlos E, Pacheco, Mauro F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Dose-Response Relationship, Drug Double-Blind Method Female Headache - chemically induced Histamine Agonists - adverse effects Histamine Agonists - pharmacology Histamine Agonists - therapeutic use Humans Male Methylhistamines - adverse effects Methylhistamines - pharmacology Methylhistamines - therapeutic use Middle Aged Migraine Disorders - prevention & control Receptors, Histamine - metabolism Treatment Outcome
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