Sevoflurane Exposure Generates Superoxide but Leads to Decreased Superoxide During Ischemia and Reperfusion in Isolated Hearts

Reactive oxygen species (ROS) are largely responsible for cardiac injury consequent to ischemia and reperfusion, but, paradoxically, there is evidence suggesting that anesthetics induce preconditioning (APC) by generating ROS. We hypothesized that sevoflurane generates the ROS superoxide (O2·−), tha...

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Veröffentlicht in:	Anesthesia and analgesia 2003-04, Vol.96 (4), p.949-955
Hauptverfasser:	Kevin, Leo G., Novalija, Enis, Riess, Matthias L., Camara, Amadou K. S., Rhodes, Samhita S., Stowe, David F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Inhalation - pharmacology Animals ATP-Binding Cassette Transporters Blood Pressure - drug effects Calcium - metabolism Coronary Circulation - drug effects Electron Transport - drug effects Ethidium - analogs & derivatives Fluorescent Dyes Free Radical Scavengers - pharmacology Guinea Pigs Heart Ventricles - drug effects Heart Ventricles - metabolism In Vitro Techniques Ischemic Preconditioning, Myocardial KATP Channels Methyl Ethers - pharmacology Myocardial Reperfusion Injury - metabolism Oxidants - metabolism Potassium Channel Blockers - pharmacology Potassium Channels - drug effects Potassium Channels - metabolism Potassium Channels, Inwardly Rectifying Reactive Oxygen Species - metabolism Sevoflurane Spectrometry, Fluorescence Superoxides - metabolism Ventricular Function, Left - drug effects
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