[99mTc] Liposomes for localizing experimental colitis in a rabbit model
[(99m)Tc] liposomes (TL) and [(111)In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [(99m)...
Gespeichert in:
| Veröffentlicht in: | Nuclear medicine and biology 2003-02, Vol.30 (2), p.159-168 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 168 |
|---|---|
| container_issue | 2 |
| container_start_page | 159 |
| container_title | Nuclear medicine and biology |
| container_volume | 30 |
| creator | AWASTHI, Vibhudutta GOINS, Beth MCMANUS, Linda KLIPPER, Robert PHILLIPS, William T |
| description | [(99m)Tc] liposomes (TL) and [(111)In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [(99m)Tc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [(111)In] WBCs. The study demonstrates the usefulness of [(99m)Tc] liposomes for imaging inflammatory bowel diseases. |
| doi_str_mv | 10.1016/S0969-8051(02)00419-5 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_pasca</sourceid><recordid>TN_cdi_pubmed_primary_12623115</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>12623115</sourcerecordid><originalsourceid>FETCH-LOGICAL-p237t-b0d2c7320ee370c12ae516e06ae5fc108b6a1f14edf7ac25a089cc3b8a91f22e3</originalsourceid><addsrcrecordid>eNpFj01LxDAURYMoOo7-BCUbQRfV95ImaZYy6CgMuHBciQxp-iKRftFUUH-9BUdd3c25l3sYO0G4REB99QhW26wAhecgLgBytJnaYTMsjMisxnyXzf6QA3aY0htMvRxhnx2g0EIiqhlbPlvbrP0LX8W-S11DiYdu4HXnXR2_YvvK6aOnITbUjq7mvqvjGBOPLXd8cGUZR950FdVHbC-4OtHxNufs6fZmvbjLVg_L-8X1KuuFNGNWQiW8kQKIpAGPwpFCTaCnDB6hKLXDgDlVwTgvlIPCei_LwlkMQpCcs9Of3f69bKja9NM1N3xufo0m4GwLuDQ5hMG1PqZ_LlfWKG3kNwaBW4w</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>[99mTc] Liposomes for localizing experimental colitis in a rabbit model</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>AWASTHI, Vibhudutta ; GOINS, Beth ; MCMANUS, Linda ; KLIPPER, Robert ; PHILLIPS, William T</creator><creatorcontrib>AWASTHI, Vibhudutta ; GOINS, Beth ; MCMANUS, Linda ; KLIPPER, Robert ; PHILLIPS, William T</creatorcontrib><description>[(99m)Tc] liposomes (TL) and [(111)In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [(99m)Tc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [(111)In] WBCs. The study demonstrates the usefulness of [(99m)Tc] liposomes for imaging inflammatory bowel diseases.</description><identifier>ISSN: 0969-8051</identifier><identifier>EISSN: 1872-9614</identifier><identifier>DOI: 10.1016/S0969-8051(02)00419-5</identifier><identifier>PMID: 12623115</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>Animals ; Biological and medical sciences ; Colitis - blood ; Colitis - chemically induced ; Colitis - diagnostic imaging ; Colitis - metabolism ; Dinitrochlorobenzene ; Leukocytes - diagnostic imaging ; Liposomes - pharmacokinetics ; Medical sciences ; Metabolic Clearance Rate ; Organ Specificity ; Predictive Value of Tests ; Rabbits ; Technetium - pharmacokinetics ; Tissue Distribution ; Tomography, Emission-Computed - methods ; Whole-Body Counting</subject><ispartof>Nuclear medicine and biology, 2003-02, Vol.30 (2), p.159-168</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14597567$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12623115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AWASTHI, Vibhudutta</creatorcontrib><creatorcontrib>GOINS, Beth</creatorcontrib><creatorcontrib>MCMANUS, Linda</creatorcontrib><creatorcontrib>KLIPPER, Robert</creatorcontrib><creatorcontrib>PHILLIPS, William T</creatorcontrib><title>[99mTc] Liposomes for localizing experimental colitis in a rabbit model</title><title>Nuclear medicine and biology</title><addtitle>Nucl Med Biol</addtitle><description>[(99m)Tc] liposomes (TL) and [(111)In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [(99m)Tc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [(111)In] WBCs. The study demonstrates the usefulness of [(99m)Tc] liposomes for imaging inflammatory bowel diseases.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Colitis - blood</subject><subject>Colitis - chemically induced</subject><subject>Colitis - diagnostic imaging</subject><subject>Colitis - metabolism</subject><subject>Dinitrochlorobenzene</subject><subject>Leukocytes - diagnostic imaging</subject><subject>Liposomes - pharmacokinetics</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate</subject><subject>Organ Specificity</subject><subject>Predictive Value of Tests</subject><subject>Rabbits</subject><subject>Technetium - pharmacokinetics</subject><subject>Tissue Distribution</subject><subject>Tomography, Emission-Computed - methods</subject><subject>Whole-Body Counting</subject><issn>0969-8051</issn><issn>1872-9614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj01LxDAURYMoOo7-BCUbQRfV95ImaZYy6CgMuHBciQxp-iKRftFUUH-9BUdd3c25l3sYO0G4REB99QhW26wAhecgLgBytJnaYTMsjMisxnyXzf6QA3aY0htMvRxhnx2g0EIiqhlbPlvbrP0LX8W-S11DiYdu4HXnXR2_YvvK6aOnITbUjq7mvqvjGBOPLXd8cGUZR950FdVHbC-4OtHxNufs6fZmvbjLVg_L-8X1KuuFNGNWQiW8kQKIpAGPwpFCTaCnDB6hKLXDgDlVwTgvlIPCei_LwlkMQpCcs9Of3f69bKja9NM1N3xufo0m4GwLuDQ5hMG1PqZ_LlfWKG3kNwaBW4w</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>AWASTHI, Vibhudutta</creator><creator>GOINS, Beth</creator><creator>MCMANUS, Linda</creator><creator>KLIPPER, Robert</creator><creator>PHILLIPS, William T</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20030201</creationdate><title>[99mTc] Liposomes for localizing experimental colitis in a rabbit model</title><author>AWASTHI, Vibhudutta ; GOINS, Beth ; MCMANUS, Linda ; KLIPPER, Robert ; PHILLIPS, William T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p237t-b0d2c7320ee370c12ae516e06ae5fc108b6a1f14edf7ac25a089cc3b8a91f22e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Colitis - blood</topic><topic>Colitis - chemically induced</topic><topic>Colitis - diagnostic imaging</topic><topic>Colitis - metabolism</topic><topic>Dinitrochlorobenzene</topic><topic>Leukocytes - diagnostic imaging</topic><topic>Liposomes - pharmacokinetics</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate</topic><topic>Organ Specificity</topic><topic>Predictive Value of Tests</topic><topic>Rabbits</topic><topic>Technetium - pharmacokinetics</topic><topic>Tissue Distribution</topic><topic>Tomography, Emission-Computed - methods</topic><topic>Whole-Body Counting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AWASTHI, Vibhudutta</creatorcontrib><creatorcontrib>GOINS, Beth</creatorcontrib><creatorcontrib>MCMANUS, Linda</creatorcontrib><creatorcontrib>KLIPPER, Robert</creatorcontrib><creatorcontrib>PHILLIPS, William T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Nuclear medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AWASTHI, Vibhudutta</au><au>GOINS, Beth</au><au>MCMANUS, Linda</au><au>KLIPPER, Robert</au><au>PHILLIPS, William T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>[99mTc] Liposomes for localizing experimental colitis in a rabbit model</atitle><jtitle>Nuclear medicine and biology</jtitle><addtitle>Nucl Med Biol</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>30</volume><issue>2</issue><spage>159</spage><epage>168</epage><pages>159-168</pages><issn>0969-8051</issn><eissn>1872-9614</eissn><abstract>[(99m)Tc] liposomes (TL) and [(111)In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [(99m)Tc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [(111)In] WBCs. The study demonstrates the usefulness of [(99m)Tc] liposomes for imaging inflammatory bowel diseases.</abstract><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>12623115</pmid><doi>10.1016/S0969-8051(02)00419-5</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0969-8051 |
| ispartof | Nuclear medicine and biology, 2003-02, Vol.30 (2), p.159-168 |
| issn | 0969-8051 1872-9614 |
| language | eng |
| recordid | cdi_pubmed_primary_12623115 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Colitis - blood Colitis - chemically induced Colitis - diagnostic imaging Colitis - metabolism Dinitrochlorobenzene Leukocytes - diagnostic imaging Liposomes - pharmacokinetics Medical sciences Metabolic Clearance Rate Organ Specificity Predictive Value of Tests Rabbits Technetium - pharmacokinetics Tissue Distribution Tomography, Emission-Computed - methods Whole-Body Counting |
| title | [99mTc] Liposomes for localizing experimental colitis in a rabbit model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T04%3A53%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=%5B99mTc%5D%20Liposomes%20for%20localizing%20experimental%20colitis%20in%20a%20rabbit%20model&rft.jtitle=Nuclear%20medicine%20and%20biology&rft.au=AWASTHI,%20Vibhudutta&rft.date=2003-02-01&rft.volume=30&rft.issue=2&rft.spage=159&rft.epage=168&rft.pages=159-168&rft.issn=0969-8051&rft.eissn=1872-9614&rft_id=info:doi/10.1016/S0969-8051(02)00419-5&rft_dat=%3Cpubmed_pasca%3E12623115%3C/pubmed_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/12623115&rfr_iscdi=true |