Lipopolysaccharide-binding protein in microbial invasion of the amniotic cavity and human parturition
Objective: Lipopolysaccharide-binding protein (LBP) is an acute-phase protein of predominantly hepatic origin, capable of binding the lipid A fraction of bacterial lipopolysaccharide (LPS). The complex LBP-LPS binds to CD14, and has been implicated in the host response to Gram-negative infection. Th...
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| Veröffentlicht in: | The journal of maternal-fetal & neonatal medicine 2002-11, Vol.12 (5), p.313-321 |
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| creator | Espinoza, J. Romero, R. Chaiworapongsa, T. Kim, J. C. Yoshimatsu, J. Edwin, S. Rathnasabapathy, C. Tolosa, J. Donnenfeld, A. Craparo, F. Gomez, R. Bujold, E. |
| description | Objective: Lipopolysaccharide-binding protein (LBP) is an acute-phase protein of predominantly hepatic origin, capable of binding the lipid A fraction of bacterial lipopolysaccharide (LPS). The complex
LBP-LPS binds to CD14, and has been implicated in the host response to Gram-negative infection. The purpose of this study was to determine whether microbial invasion of the amniotic cavity (MIAC) and parturition
(term and preterm) are associated with changes in the amniotic fluid concentration of LBP.
Study design: Amniotic fluid was retrieved by amniocentesis from 343 patients in the following groups:
(1) those in mid-trimester with a subsequent normal pregnancy outcome (n = 84); (2) those in mid-trimester with a fetal loss after the procedure (n = 10); (3) those with preterm labor and
intact membranes without MIAC who delivered at term (n = 36) or prematurely (n = 52), and those with preterm labor with MIAC (n = 26); (4) those with preterm premature rupture of membranes
(PROM) with (n = 26) and without (n = 26) MIAC; and (5) those delivering at term with intact membranes in the absence of MIAC, in labor (n = 52) and not in labor (n = 31). The
concentration of LBP in amniotic fluid was determined with a specific and sensitive immunoassay. Non-parametric statistics were used. A p value of < 0.05 was considered significant.
Results:
LBP was detected in 98% (335/343) of the amniotic fluid samples. MIAC was associated with a significant increase in amniotic fluid concentration of LBP in women with preterm labor and intact membranes,
but not in preterm PROM. Spontaneous preterm parturition was associated with a significant increase in amniotic fluid concentration of LBP. Patients who had a spontaneous fetal loss after a mid-trimester
amniocentesis had a significantly higher median amniotic fluid LBP concentration than those who had a mid-trimester amniocentesis and a normal perinatal outcome.
Conclusion: Preterm labor with
MIAC and preterm parturition are associated with higher amniotic fluid concentrations of LBP than those with sterile amniotic fluid. |
| doi_str_mv | 10.1080/jmf.12.5.313.321 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_12607763</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72854346</sourcerecordid><originalsourceid>FETCH-LOGICAL-c313t-9365307aa2b0835f34befca680a5390534bfe8d1ff673e3088402515e5a8569a3</originalsourceid><addsrcrecordid>eNp1kM1r3DAQxUVoyG4-7j0VnXqzK1mWrW1PZUnSwkIvyVmMZanWYkuuJG_Y_z4KuxB6CAhGA7_3ePMQ-kxJSYkg3_aTKWlV8pJRVrKKXqA1rdumqDe8_nT-t4SLFbqOcU9IRWvCr9CKVg1p24atkd7Z2c9-PEZQaoBge1101vXW_cVz8Elbh_ObrAq-szDm5QDReoe9wWnQGCZnfbIKKzjYdMTgejwsEzg8Q0hLsCnDt-jSwBj13XneoOeH-6ftr2L35_H39ueuUPmAVGxYwxlpAaqOCMYNqzttFDSCAGcbwvNutOipMU3LNCNC1KTilGsOgjcbYDfo68k3R_-36JjkZKPS4whO-yXKthK8ZnWTQXIC81kxBm3kHOwE4SgpkW_VylytpJXkMieTudos-XL2XrpJ9--Cc5cZ-HECrDM-TPDiw9jLBMfRBxPAKRuz2cf23_9TDxrGNCgIWu79Elyu7eNsr5twnfk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72854346</pqid></control><display><type>article</type><title>Lipopolysaccharide-binding protein in microbial invasion of the amniotic cavity and human parturition</title><source>MEDLINE</source><source>Taylor & Francis:Master (3349 titles)</source><creator>Espinoza, J. ; Romero, R. ; Chaiworapongsa, T. ; Kim, J. C. ; Yoshimatsu, J. ; Edwin, S. ; Rathnasabapathy, C. ; Tolosa, J. ; Donnenfeld, A. ; Craparo, F. ; Gomez, R. ; Bujold, E.</creator><creatorcontrib>Espinoza, J. ; Romero, R. ; Chaiworapongsa, T. ; Kim, J. C. ; Yoshimatsu, J. ; Edwin, S. ; Rathnasabapathy, C. ; Tolosa, J. ; Donnenfeld, A. ; Craparo, F. ; Gomez, R. ; Bujold, E.</creatorcontrib><description>Objective: Lipopolysaccharide-binding protein (LBP) is an acute-phase protein of predominantly hepatic origin, capable of binding the lipid A fraction of bacterial lipopolysaccharide (LPS). The complex
LBP-LPS binds to CD14, and has been implicated in the host response to Gram-negative infection. The purpose of this study was to determine whether microbial invasion of the amniotic cavity (MIAC) and parturition
(term and preterm) are associated with changes in the amniotic fluid concentration of LBP.
Study design: Amniotic fluid was retrieved by amniocentesis from 343 patients in the following groups:
(1) those in mid-trimester with a subsequent normal pregnancy outcome (n = 84); (2) those in mid-trimester with a fetal loss after the procedure (n = 10); (3) those with preterm labor and
intact membranes without MIAC who delivered at term (n = 36) or prematurely (n = 52), and those with preterm labor with MIAC (n = 26); (4) those with preterm premature rupture of membranes
(PROM) with (n = 26) and without (n = 26) MIAC; and (5) those delivering at term with intact membranes in the absence of MIAC, in labor (n = 52) and not in labor (n = 31). The
concentration of LBP in amniotic fluid was determined with a specific and sensitive immunoassay. Non-parametric statistics were used. A p value of < 0.05 was considered significant.
Results:
LBP was detected in 98% (335/343) of the amniotic fluid samples. MIAC was associated with a significant increase in amniotic fluid concentration of LBP in women with preterm labor and intact membranes,
but not in preterm PROM. Spontaneous preterm parturition was associated with a significant increase in amniotic fluid concentration of LBP. Patients who had a spontaneous fetal loss after a mid-trimester
amniocentesis had a significantly higher median amniotic fluid LBP concentration than those who had a mid-trimester amniocentesis and a normal perinatal outcome.
Conclusion: Preterm labor with
MIAC and preterm parturition are associated with higher amniotic fluid concentrations of LBP than those with sterile amniotic fluid.</description><identifier>ISSN: 1476-7058</identifier><identifier>EISSN: 1476-4954</identifier><identifier>DOI: 10.1080/jmf.12.5.313.321</identifier><identifier>PMID: 12607763</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Acute-Phase Proteins ; Amniocentesis ; Amnion - immunology ; Amnion - microbiology ; AMNIOTIC FLUID ; Amniotic Fluid - chemistry ; Amniotic Fluid - immunology ; Carrier Proteins - analysis ; Carrier Proteins - immunology ; CHORIOAMNIONITIS ; Chorioamnionitis - immunology ; Chorioamnionitis - microbiology ; Cross-Sectional Studies ; ENDOTOXIN ; Female ; Fetal Death - immunology ; Fetal Membranes, Premature Rupture - immunology ; Humans ; LIPOPOLYSACCHARIDE-BINDING PROTEIN ; Membrane Glycoproteins ; Obstetric Labor, Premature - immunology ; Parturition - immunology ; Pregnancy ; Pregnancy Complications, Infectious - immunology ; PRETERM LABOR ; TOLL-LIKE RECEPTOR</subject><ispartof>The journal of maternal-fetal & neonatal medicine, 2002-11, Vol.12 (5), p.313-321</ispartof><rights>2002 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-9365307aa2b0835f34befca680a5390534bfe8d1ff673e3088402515e5a8569a3</citedby><cites>FETCH-LOGICAL-c313t-9365307aa2b0835f34befca680a5390534bfe8d1ff673e3088402515e5a8569a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/jmf.12.5.313.321$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/jmf.12.5.313.321$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,59646,60435,61220,61401</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12607763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Espinoza, J.</creatorcontrib><creatorcontrib>Romero, R.</creatorcontrib><creatorcontrib>Chaiworapongsa, T.</creatorcontrib><creatorcontrib>Kim, J. C.</creatorcontrib><creatorcontrib>Yoshimatsu, J.</creatorcontrib><creatorcontrib>Edwin, S.</creatorcontrib><creatorcontrib>Rathnasabapathy, C.</creatorcontrib><creatorcontrib>Tolosa, J.</creatorcontrib><creatorcontrib>Donnenfeld, A.</creatorcontrib><creatorcontrib>Craparo, F.</creatorcontrib><creatorcontrib>Gomez, R.</creatorcontrib><creatorcontrib>Bujold, E.</creatorcontrib><title>Lipopolysaccharide-binding protein in microbial invasion of the amniotic cavity and human parturition</title><title>The journal of maternal-fetal & neonatal medicine</title><addtitle>J Matern Fetal Neonatal Med</addtitle><description>Objective: Lipopolysaccharide-binding protein (LBP) is an acute-phase protein of predominantly hepatic origin, capable of binding the lipid A fraction of bacterial lipopolysaccharide (LPS). The complex
LBP-LPS binds to CD14, and has been implicated in the host response to Gram-negative infection. The purpose of this study was to determine whether microbial invasion of the amniotic cavity (MIAC) and parturition
(term and preterm) are associated with changes in the amniotic fluid concentration of LBP.
Study design: Amniotic fluid was retrieved by amniocentesis from 343 patients in the following groups:
(1) those in mid-trimester with a subsequent normal pregnancy outcome (n = 84); (2) those in mid-trimester with a fetal loss after the procedure (n = 10); (3) those with preterm labor and
intact membranes without MIAC who delivered at term (n = 36) or prematurely (n = 52), and those with preterm labor with MIAC (n = 26); (4) those with preterm premature rupture of membranes
(PROM) with (n = 26) and without (n = 26) MIAC; and (5) those delivering at term with intact membranes in the absence of MIAC, in labor (n = 52) and not in labor (n = 31). The
concentration of LBP in amniotic fluid was determined with a specific and sensitive immunoassay. Non-parametric statistics were used. A p value of < 0.05 was considered significant.
Results:
LBP was detected in 98% (335/343) of the amniotic fluid samples. MIAC was associated with a significant increase in amniotic fluid concentration of LBP in women with preterm labor and intact membranes,
but not in preterm PROM. Spontaneous preterm parturition was associated with a significant increase in amniotic fluid concentration of LBP. Patients who had a spontaneous fetal loss after a mid-trimester
amniocentesis had a significantly higher median amniotic fluid LBP concentration than those who had a mid-trimester amniocentesis and a normal perinatal outcome.
Conclusion: Preterm labor with
MIAC and preterm parturition are associated with higher amniotic fluid concentrations of LBP than those with sterile amniotic fluid.</description><subject>Acute-Phase Proteins</subject><subject>Amniocentesis</subject><subject>Amnion - immunology</subject><subject>Amnion - microbiology</subject><subject>AMNIOTIC FLUID</subject><subject>Amniotic Fluid - chemistry</subject><subject>Amniotic Fluid - immunology</subject><subject>Carrier Proteins - analysis</subject><subject>Carrier Proteins - immunology</subject><subject>CHORIOAMNIONITIS</subject><subject>Chorioamnionitis - immunology</subject><subject>Chorioamnionitis - microbiology</subject><subject>Cross-Sectional Studies</subject><subject>ENDOTOXIN</subject><subject>Female</subject><subject>Fetal Death - immunology</subject><subject>Fetal Membranes, Premature Rupture - immunology</subject><subject>Humans</subject><subject>LIPOPOLYSACCHARIDE-BINDING PROTEIN</subject><subject>Membrane Glycoproteins</subject><subject>Obstetric Labor, Premature - immunology</subject><subject>Parturition - immunology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - immunology</subject><subject>PRETERM LABOR</subject><subject>TOLL-LIKE RECEPTOR</subject><issn>1476-7058</issn><issn>1476-4954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1r3DAQxUVoyG4-7j0VnXqzK1mWrW1PZUnSwkIvyVmMZanWYkuuJG_Y_z4KuxB6CAhGA7_3ePMQ-kxJSYkg3_aTKWlV8pJRVrKKXqA1rdumqDe8_nT-t4SLFbqOcU9IRWvCr9CKVg1p24atkd7Z2c9-PEZQaoBge1101vXW_cVz8Elbh_ObrAq-szDm5QDReoe9wWnQGCZnfbIKKzjYdMTgejwsEzg8Q0hLsCnDt-jSwBj13XneoOeH-6ftr2L35_H39ueuUPmAVGxYwxlpAaqOCMYNqzttFDSCAGcbwvNutOipMU3LNCNC1KTilGsOgjcbYDfo68k3R_-36JjkZKPS4whO-yXKthK8ZnWTQXIC81kxBm3kHOwE4SgpkW_VylytpJXkMieTudos-XL2XrpJ9--Cc5cZ-HECrDM-TPDiw9jLBMfRBxPAKRuz2cf23_9TDxrGNCgIWu79Elyu7eNsr5twnfk</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Espinoza, J.</creator><creator>Romero, R.</creator><creator>Chaiworapongsa, T.</creator><creator>Kim, J. C.</creator><creator>Yoshimatsu, J.</creator><creator>Edwin, S.</creator><creator>Rathnasabapathy, C.</creator><creator>Tolosa, J.</creator><creator>Donnenfeld, A.</creator><creator>Craparo, F.</creator><creator>Gomez, R.</creator><creator>Bujold, E.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Lipopolysaccharide-binding protein in microbial invasion of the amniotic cavity and human parturition</title><author>Espinoza, J. ; Romero, R. ; Chaiworapongsa, T. ; Kim, J. C. ; Yoshimatsu, J. ; Edwin, S. ; Rathnasabapathy, C. ; Tolosa, J. ; Donnenfeld, A. ; Craparo, F. ; Gomez, R. ; Bujold, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-9365307aa2b0835f34befca680a5390534bfe8d1ff673e3088402515e5a8569a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acute-Phase Proteins</topic><topic>Amniocentesis</topic><topic>Amnion - immunology</topic><topic>Amnion - microbiology</topic><topic>AMNIOTIC FLUID</topic><topic>Amniotic Fluid - chemistry</topic><topic>Amniotic Fluid - immunology</topic><topic>Carrier Proteins - analysis</topic><topic>Carrier Proteins - immunology</topic><topic>CHORIOAMNIONITIS</topic><topic>Chorioamnionitis - immunology</topic><topic>Chorioamnionitis - microbiology</topic><topic>Cross-Sectional Studies</topic><topic>ENDOTOXIN</topic><topic>Female</topic><topic>Fetal Death - immunology</topic><topic>Fetal Membranes, Premature Rupture - immunology</topic><topic>Humans</topic><topic>LIPOPOLYSACCHARIDE-BINDING PROTEIN</topic><topic>Membrane Glycoproteins</topic><topic>Obstetric Labor, Premature - immunology</topic><topic>Parturition - immunology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - immunology</topic><topic>PRETERM LABOR</topic><topic>TOLL-LIKE RECEPTOR</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Espinoza, J.</creatorcontrib><creatorcontrib>Romero, R.</creatorcontrib><creatorcontrib>Chaiworapongsa, T.</creatorcontrib><creatorcontrib>Kim, J. C.</creatorcontrib><creatorcontrib>Yoshimatsu, J.</creatorcontrib><creatorcontrib>Edwin, S.</creatorcontrib><creatorcontrib>Rathnasabapathy, C.</creatorcontrib><creatorcontrib>Tolosa, J.</creatorcontrib><creatorcontrib>Donnenfeld, A.</creatorcontrib><creatorcontrib>Craparo, F.</creatorcontrib><creatorcontrib>Gomez, R.</creatorcontrib><creatorcontrib>Bujold, E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Espinoza, J.</au><au>Romero, R.</au><au>Chaiworapongsa, T.</au><au>Kim, J. C.</au><au>Yoshimatsu, J.</au><au>Edwin, S.</au><au>Rathnasabapathy, C.</au><au>Tolosa, J.</au><au>Donnenfeld, A.</au><au>Craparo, F.</au><au>Gomez, R.</au><au>Bujold, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipopolysaccharide-binding protein in microbial invasion of the amniotic cavity and human parturition</atitle><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle><addtitle>J Matern Fetal Neonatal Med</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>12</volume><issue>5</issue><spage>313</spage><epage>321</epage><pages>313-321</pages><issn>1476-7058</issn><eissn>1476-4954</eissn><abstract>Objective: Lipopolysaccharide-binding protein (LBP) is an acute-phase protein of predominantly hepatic origin, capable of binding the lipid A fraction of bacterial lipopolysaccharide (LPS). The complex
LBP-LPS binds to CD14, and has been implicated in the host response to Gram-negative infection. The purpose of this study was to determine whether microbial invasion of the amniotic cavity (MIAC) and parturition
(term and preterm) are associated with changes in the amniotic fluid concentration of LBP.
Study design: Amniotic fluid was retrieved by amniocentesis from 343 patients in the following groups:
(1) those in mid-trimester with a subsequent normal pregnancy outcome (n = 84); (2) those in mid-trimester with a fetal loss after the procedure (n = 10); (3) those with preterm labor and
intact membranes without MIAC who delivered at term (n = 36) or prematurely (n = 52), and those with preterm labor with MIAC (n = 26); (4) those with preterm premature rupture of membranes
(PROM) with (n = 26) and without (n = 26) MIAC; and (5) those delivering at term with intact membranes in the absence of MIAC, in labor (n = 52) and not in labor (n = 31). The
concentration of LBP in amniotic fluid was determined with a specific and sensitive immunoassay. Non-parametric statistics were used. A p value of < 0.05 was considered significant.
Results:
LBP was detected in 98% (335/343) of the amniotic fluid samples. MIAC was associated with a significant increase in amniotic fluid concentration of LBP in women with preterm labor and intact membranes,
but not in preterm PROM. Spontaneous preterm parturition was associated with a significant increase in amniotic fluid concentration of LBP. Patients who had a spontaneous fetal loss after a mid-trimester
amniocentesis had a significantly higher median amniotic fluid LBP concentration than those who had a mid-trimester amniocentesis and a normal perinatal outcome.
Conclusion: Preterm labor with
MIAC and preterm parturition are associated with higher amniotic fluid concentrations of LBP than those with sterile amniotic fluid.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>12607763</pmid><doi>10.1080/jmf.12.5.313.321</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1476-7058 |
| ispartof | The journal of maternal-fetal & neonatal medicine, 2002-11, Vol.12 (5), p.313-321 |
| issn | 1476-7058 1476-4954 |
| language | eng |
| recordid | cdi_pubmed_primary_12607763 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles) |
| subjects | Acute-Phase Proteins Amniocentesis Amnion - immunology Amnion - microbiology AMNIOTIC FLUID Amniotic Fluid - chemistry Amniotic Fluid - immunology Carrier Proteins - analysis Carrier Proteins - immunology CHORIOAMNIONITIS Chorioamnionitis - immunology Chorioamnionitis - microbiology Cross-Sectional Studies ENDOTOXIN Female Fetal Death - immunology Fetal Membranes, Premature Rupture - immunology Humans LIPOPOLYSACCHARIDE-BINDING PROTEIN Membrane Glycoproteins Obstetric Labor, Premature - immunology Parturition - immunology Pregnancy Pregnancy Complications, Infectious - immunology PRETERM LABOR TOLL-LIKE RECEPTOR |
| title | Lipopolysaccharide-binding protein in microbial invasion of the amniotic cavity and human parturition |
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