No Evidence for an Association between the T102C and 1438 G/A Polymorphisms of the Serotonin 2A Receptor Gene in Attention Deficit/Hyperactivity Disorder in a Turkish Population
Disturbances in the serotonergic neurotransmission system have been implicated in the etiology of attenion deficit/hyperactivity disorder (ADHD). As the importance of genetic factors is well established, genes encoding for proteins of the serotonergic pathway are important candidates to unravel the...
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| Veröffentlicht in: | Neuropsychobiology 2003-01, Vol.47 (1), p.17-20 |
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| creator | Zoroglu, Suleyman Salih Erdal, Mehmet Emin Erdal, Nurten Ozen, Sakır Alasehirli, Belgin Sivasli, Ercan |
| description | Disturbances in the serotonergic neurotransmission system have been implicated in the etiology of attenion deficit/hyperactivity disorder (ADHD). As the importance of genetic factors is well established, genes encoding for proteins of the serotonergic pathway are important candidates to unravel the underlying genetic contribution. We previously demonstrated that the polymorphisms of the serotonin transporter gene promoter and regions of variable number of tandem repeats were involved in the pathogenesis of ADHD. The purpose of this study was to examine the relationship between ADHD and two polymorphisms (T102C and 1438 G/A) in the 5-HT2A gene in a sample of Turkish children. Using the PCR technique, these polymorphisms were assessed in 70 patients with ADHD and in 100 healthy controls. There was no significant difference between the frequencies of the T, C, G and A alleles of both groups. No association was found between the studied polymorphisms of the 5-HT2A gene and ADHD in this sample consisting of Turkish children. Overall, our results suggest that the investigated 5-HT2A polymorphisms are not major susceptibility factors in the etiology of ADHD. |
| doi_str_mv | 10.1159/000068870 |
| format | Article |
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As the importance of genetic factors is well established, genes encoding for proteins of the serotonergic pathway are important candidates to unravel the underlying genetic contribution. We previously demonstrated that the polymorphisms of the serotonin transporter gene promoter and regions of variable number of tandem repeats were involved in the pathogenesis of ADHD. The purpose of this study was to examine the relationship between ADHD and two polymorphisms (T102C and 1438 G/A) in the 5-HT2A gene in a sample of Turkish children. Using the PCR technique, these polymorphisms were assessed in 70 patients with ADHD and in 100 healthy controls. There was no significant difference between the frequencies of the T, C, G and A alleles of both groups. No association was found between the studied polymorphisms of the 5-HT2A gene and ADHD in this sample consisting of Turkish children. Overall, our results suggest that the investigated 5-HT2A polymorphisms are not major susceptibility factors in the etiology of ADHD.</description><identifier>ISSN: 0302-282X</identifier><identifier>EISSN: 1423-0224</identifier><identifier>DOI: 10.1159/000068870</identifier><identifier>PMID: 12606840</identifier><identifier>CODEN: NPBYAL</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adolescent ; Attention Deficit Disorder with Hyperactivity - genetics ; Attention Deficit Disorder with Hyperactivity - metabolism ; Attention deficit disorders. Hyperactivity ; Biological and medical sciences ; Biological Psychiatry. Editor: J. Mendlewicz (Brussels). Original Paper ; Case-Control Studies ; Child ; Child clinical studies ; DNA - genetics ; Female ; Gene Frequency ; Genotype ; Humans ; Male ; Medical sciences ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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As the importance of genetic factors is well established, genes encoding for proteins of the serotonergic pathway are important candidates to unravel the underlying genetic contribution. We previously demonstrated that the polymorphisms of the serotonin transporter gene promoter and regions of variable number of tandem repeats were involved in the pathogenesis of ADHD. The purpose of this study was to examine the relationship between ADHD and two polymorphisms (T102C and 1438 G/A) in the 5-HT2A gene in a sample of Turkish children. Using the PCR technique, these polymorphisms were assessed in 70 patients with ADHD and in 100 healthy controls. There was no significant difference between the frequencies of the T, C, G and A alleles of both groups. No association was found between the studied polymorphisms of the 5-HT2A gene and ADHD in this sample consisting of Turkish children. Overall, our results suggest that the investigated 5-HT2A polymorphisms are not major susceptibility factors in the etiology of ADHD.</description><subject>Adolescent</subject><subject>Attention Deficit Disorder with Hyperactivity - genetics</subject><subject>Attention Deficit Disorder with Hyperactivity - metabolism</subject><subject>Attention deficit disorders. Hyperactivity</subject><subject>Biological and medical sciences</subject><subject>Biological Psychiatry. Editor: J. Mendlewicz (Brussels). Original Paper</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>DNA - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Receptor, Serotonin, 5-HT2A</subject><subject>Receptors, Serotonin - genetics</subject><subject>Receptors, Serotonin - metabolism</subject><subject>Turkey</subject><issn>0302-282X</issn><issn>1423-0224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UFrFDEUB_Agil2rB8-CBEHBw7hJJjOTOQ7bdiuUWuwK3oZM5sWNnU2mSaayH6vf0HR3aS-CuQTCL__3eA-ht5R8obSo5ySdUoiKPEMzylmeEcb4czQjOWEZE-znEXoVwm9CKK-r-iU6oqxMHziZoftLh0_vTA9WAdbOY2lxE4JTRkbjLO4g_gGwOK4BryhhiwR6THku8HLe4Cs3bDfOj2sTNgE7vXPX4F101ljMGvwdFIwxBS_BAk5vTYxgd9knoI0ycX6-HcFLFc2diVt8YoLzPfgHK_Fq8jcmrFOhcRp2Lb1GL7QcArw53Mfox9npanGeXXxbfl00F5nKRR0zLaHOaV3okokeSMVlXVa8k30vFFedrkClYRRUE-i07rSogLBOCSYEg7yn-TH6tM8dvbudIMR2Y4KCYZAW3BTaKidllSL_CxmpGS-pSPDzHirvQvCg29GbjfTblpL2YZHt4yKTfX8InboN9E_ysLkEPh6ADEoO2kurTHhyvBBVUZbJfdi7G-l_gX8El1fXu0rt2OuE3v0T7Xv5CwL5uuY</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Zoroglu, Suleyman Salih</creator><creator>Erdal, Mehmet Emin</creator><creator>Erdal, Nurten</creator><creator>Ozen, Sakır</creator><creator>Alasehirli, Belgin</creator><creator>Sivasli, Ercan</creator><general>Karger</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200301</creationdate><title>No Evidence for an Association between the T102C and 1438 G/A Polymorphisms of the Serotonin 2A Receptor Gene in Attention Deficit/Hyperactivity Disorder in a Turkish Population</title><author>Zoroglu, Suleyman Salih ; Erdal, Mehmet Emin ; Erdal, Nurten ; Ozen, Sakır ; Alasehirli, Belgin ; Sivasli, Ercan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-fae93195f628de074a9674badd8c4cbf7ec49751f0ebffbf87e02bc82882e3d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Attention Deficit Disorder with Hyperactivity - genetics</topic><topic>Attention Deficit Disorder with Hyperactivity - metabolism</topic><topic>Attention deficit disorders. Hyperactivity</topic><topic>Biological and medical sciences</topic><topic>Biological Psychiatry. Editor: J. Mendlewicz (Brussels). Original Paper</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>DNA - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Receptor, Serotonin, 5-HT2A</topic><topic>Receptors, Serotonin - genetics</topic><topic>Receptors, Serotonin - metabolism</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zoroglu, Suleyman Salih</creatorcontrib><creatorcontrib>Erdal, Mehmet Emin</creatorcontrib><creatorcontrib>Erdal, Nurten</creatorcontrib><creatorcontrib>Ozen, Sakır</creatorcontrib><creatorcontrib>Alasehirli, Belgin</creatorcontrib><creatorcontrib>Sivasli, Ercan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropsychobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zoroglu, Suleyman Salih</au><au>Erdal, Mehmet Emin</au><au>Erdal, Nurten</au><au>Ozen, Sakır</au><au>Alasehirli, Belgin</au><au>Sivasli, Ercan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No Evidence for an Association between the T102C and 1438 G/A Polymorphisms of the Serotonin 2A Receptor Gene in Attention Deficit/Hyperactivity Disorder in a Turkish Population</atitle><jtitle>Neuropsychobiology</jtitle><addtitle>Neuropsychobiology</addtitle><date>2003-01</date><risdate>2003</risdate><volume>47</volume><issue>1</issue><spage>17</spage><epage>20</epage><pages>17-20</pages><issn>0302-282X</issn><eissn>1423-0224</eissn><coden>NPBYAL</coden><abstract>Disturbances in the serotonergic neurotransmission system have been implicated in the etiology of attenion deficit/hyperactivity disorder (ADHD). As the importance of genetic factors is well established, genes encoding for proteins of the serotonergic pathway are important candidates to unravel the underlying genetic contribution. We previously demonstrated that the polymorphisms of the serotonin transporter gene promoter and regions of variable number of tandem repeats were involved in the pathogenesis of ADHD. The purpose of this study was to examine the relationship between ADHD and two polymorphisms (T102C and 1438 G/A) in the 5-HT2A gene in a sample of Turkish children. Using the PCR technique, these polymorphisms were assessed in 70 patients with ADHD and in 100 healthy controls. There was no significant difference between the frequencies of the T, C, G and A alleles of both groups. No association was found between the studied polymorphisms of the 5-HT2A gene and ADHD in this sample consisting of Turkish children. 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| subjects | Adolescent Attention Deficit Disorder with Hyperactivity - genetics Attention Deficit Disorder with Hyperactivity - metabolism Attention deficit disorders. Hyperactivity Biological and medical sciences Biological Psychiatry. Editor: J. Mendlewicz (Brussels). Original Paper Case-Control Studies Child Child clinical studies DNA - genetics Female Gene Frequency Genotype Humans Male Medical sciences Polymerase Chain Reaction Polymorphism, Genetic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptor, Serotonin, 5-HT2A Receptors, Serotonin - genetics Receptors, Serotonin - metabolism Turkey |
| title | No Evidence for an Association between the T102C and 1438 G/A Polymorphisms of the Serotonin 2A Receptor Gene in Attention Deficit/Hyperactivity Disorder in a Turkish Population |
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