Inhibition of the bacterial surface protein anchoring transpeptidase sortase by medicinal plants

Inhibition by medicinal plant extracts of a recombinant sortase was evaluated for antibacterial drug discovery. The coding region of sortase, a transpeptidase that cleaves surface proteins of Gram-positive bacteria, was amplified by PCR from the chromosome of Staphylococcus aureus ATCC 6538p with th...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2002-12, Vol.66 (12), p.2751-2754
Hauptverfasser:	Kim, S.W. (Seoul National Univ., Suwon (Korea R.)), Chang, I.M, Oh, K.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacyltransferases - antagonists & inhibitors Aminoacyltransferases - isolation & purification Aminoacyltransferases - metabolism ANTIMICROBIAL PROPERTIES BACTERIA Bacterial Proteins Biological and medical sciences CHROMATOGRAPHY Cysteine Endopeptidases Drug Evaluation, Preclinical DRUG PLANTS FRITILLARIA General pharmacology INHIBITION inhibitory activity Inhibitory Concentration 50 Medical sciences medicinal plants Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Plants, Medicinal - chemistry PROTEINS RHUS sortase expression STAPHYLOCOCCUS AUREUS Staphylococcus aureus - enzymology TRANSFERASES
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