Impact of hypercholesterolemia on in vitro toxicity of N-nitrosodiethylamine: effect on lipidperoxidation of blood and tissue
In vitro treatment of erythrocytes of normal and hypercholesterolemic rats with N-nitrosodiethylamine (NDEA), an important carcinogen frequently present in human environment and food chain resulted in a marginal increase in osmotic fragility of erythrocytes without affecting their antioxygenic poten...
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| Veröffentlicht in: | Indian journal of experimental biology 2002-09, Vol.40 (9), p.1071 |
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| container_title | Indian journal of experimental biology |
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| creator | Mittal, Gaurav Kaur, Manpreet Soni, Giridhar |
| description | In vitro treatment of erythrocytes of normal and hypercholesterolemic rats with N-nitrosodiethylamine (NDEA), an important carcinogen frequently present in human environment and food chain resulted in a marginal increase in osmotic fragility of erythrocytes without affecting their antioxygenic potential as evidenced by insignificant effect on lipid peroxidation (LPO). However, (LPO) of all the tissues (heart, lung, liver, kidney and spleen) increased significantly on in vitro treatment with NDEA. The effects were different in different tissues under different dietary conditions |
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However, (LPO) of all the tissues (heart, lung, liver, kidney and spleen) increased significantly on in vitro treatment with NDEA. 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However, (LPO) of all the tissues (heart, lung, liver, kidney and spleen) increased significantly on in vitro treatment with NDEA. The effects were different in different tissues under different dietary conditions</description><subject>Alkylating Agents - toxicity</subject><subject>Animals</subject><subject>Dietary Supplements</subject><subject>Diethylnitrosamine - toxicity</subject><subject>Erythrocytes - drug effects</subject><subject>Heart - physiology</subject><subject>Hypercholesterolemia - blood</subject><subject>In Vitro Techniques</subject><subject>Kidney - metabolism</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - metabolism</subject><subject>Lung - metabolism</subject><subject>Male</subject><subject>Osmotic Fragility - drug effects</subject><subject>Rats</subject><subject>Spleen - metabolism</subject><issn>0019-5189</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtLxDAcxHNQ3HX1K0i-QCGPNmm9yeJjYdGLnpc8_mEjbRKarNiD390W3dPAMPODmQu0JoR2VUPbboWuc_4kRDRdR67QirKmlbIma_SzG5IyBUeHj1OC0RxjD7nAOMvgFY4B-4C_fBkjLvHbG1-mJfxahcXL0Xoox6lXgw9wj8E5WGgB9z55OwPnjlXFz87c0n2MFqtgcfE5n-AGXTrVZ7j91w36eHp8375U-7fn3fZhXyXKWKmEVlZzbYmWrWnbxnRKzhMUs4oKwUxNnTOSas0kr7kTylJgDFgjuQDOHd-guz9uOukB7CGNflDjdDj_wH8Btj1cVQ</recordid><startdate>200209</startdate><enddate>200209</enddate><creator>Mittal, Gaurav</creator><creator>Kaur, Manpreet</creator><creator>Soni, Giridhar</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200209</creationdate><title>Impact of hypercholesterolemia on in vitro toxicity of N-nitrosodiethylamine: effect on lipidperoxidation of blood and tissue</title><author>Mittal, Gaurav ; Kaur, Manpreet ; Soni, Giridhar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p122t-6badb3bd0b78c885c9a7125a2da1662c41ffc71bb27343f6ad1e22e25736e33f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Alkylating Agents - toxicity</topic><topic>Animals</topic><topic>Dietary Supplements</topic><topic>Diethylnitrosamine - toxicity</topic><topic>Erythrocytes - drug effects</topic><topic>Heart - physiology</topic><topic>Hypercholesterolemia - blood</topic><topic>In Vitro Techniques</topic><topic>Kidney - metabolism</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - metabolism</topic><topic>Lung - metabolism</topic><topic>Male</topic><topic>Osmotic Fragility - drug effects</topic><topic>Rats</topic><topic>Spleen - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mittal, Gaurav</creatorcontrib><creatorcontrib>Kaur, Manpreet</creatorcontrib><creatorcontrib>Soni, Giridhar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Indian journal of experimental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mittal, Gaurav</au><au>Kaur, Manpreet</au><au>Soni, Giridhar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of hypercholesterolemia on in vitro toxicity of N-nitrosodiethylamine: effect on lipidperoxidation of blood and tissue</atitle><jtitle>Indian journal of experimental biology</jtitle><addtitle>Indian J Exp Biol</addtitle><date>2002-09</date><risdate>2002</risdate><volume>40</volume><issue>9</issue><spage>1071</spage><pages>1071-</pages><issn>0019-5189</issn><abstract>In vitro treatment of erythrocytes of normal and hypercholesterolemic rats with N-nitrosodiethylamine (NDEA), an important carcinogen frequently present in human environment and food chain resulted in a marginal increase in osmotic fragility of erythrocytes without affecting their antioxygenic potential as evidenced by insignificant effect on lipid peroxidation (LPO). However, (LPO) of all the tissues (heart, lung, liver, kidney and spleen) increased significantly on in vitro treatment with NDEA. The effects were different in different tissues under different dietary conditions</abstract><cop>India</cop><pmid>12587740</pmid></addata></record> |
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| ispartof | Indian journal of experimental biology, 2002-09, Vol.40 (9), p.1071 |
| issn | 0019-5189 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Alkylating Agents - toxicity Animals Dietary Supplements Diethylnitrosamine - toxicity Erythrocytes - drug effects Heart - physiology Hypercholesterolemia - blood In Vitro Techniques Kidney - metabolism Lipid Peroxidation - drug effects Liver - metabolism Lung - metabolism Male Osmotic Fragility - drug effects Rats Spleen - metabolism |
| title | Impact of hypercholesterolemia on in vitro toxicity of N-nitrosodiethylamine: effect on lipidperoxidation of blood and tissue |
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